Wren

At Sundance, hundreds march down Park City’s Main Street for ‘ICE OUT’ protest With filmmakers and other famous names gathered in Park City for Sundance, hundreds of protesters took to Main Street, chanting “shoot movies, not people” during an “ICE OUT” protest meant to “stand in solidarity with Minnesota.”

One organizer, Park City pro skier and activist Sierra Quitiquit, called the protest an “extremely grassroots” effort and event.

“I wanted to get people in the streets,” Quiitiquit said, “rather than mourning alone at home.”

COVID-19 associated neurological and psychological manifestations - Nature Reviews Disease Primers This PrimeView highlights the mechanisms of COVID-19-associated neurological and psychological manifestations, and accompanies the Primer on this topic by Wilson et al.

Long COVID
Measurable biologically grounded, clinically significant not a vague or psychological label
@virusesimmunity.bsky.social
@michaelpelusomd.bsky.social
@daltmann.bsky.social
@weselymd.bsky.social
@nisreenalwan.bsky.social et al
@natrevdiseaseprimers.nature.com
www.nature.com/articles/s41...

COVID-19-associated neurological and psychological manifestations - Nature Reviews Disease Primers This Primer by Wilson and colleagues summarizes the epidemiology, pathophysiology, diagnosis and treatment of neurological and psychiatric manifestations of COVID-19.

👉 New paper highlights that Long COVID is a widespread, multisystem condition with significant neurological & psychological impacts, underscoring urgent need for recognition, care & sustained public‑health attention - to improve the lives of those affected. @nature.com
www.nature.com/articles/s41...

I wish there was a summary paper like that which provided an overview of impacts of C19 infections for those who have apparently recovered - eg increased risk of cancer, heart disease, dementia, opportunistic infections

THATS A LITERAL RED!!! Let a city player do that and it’s a straight red!!

Your City squad for today 🩵

🚨*𝗡𝗘𝗪 𝗣𝗢𝗗𝗖𝗔𝗦𝗧*🚨

📆𝗕𝗔𝗖𝗞 𝗔𝗡𝗗 𝗙𝗢𝗥𝗪𝗔𝗥𝗗📆

🎙️@stetudor.bsky.social & @georgecockburn.bsky.social revisit the Stadium of Light, look ahead to managerless Chelsea and review 2025 in the Premier League.

➡️ soundcloud.com/9320pod/the-...

🚨*𝗡𝗘𝗪𝗦𝗟𝗘𝗧𝗧𝗘𝗥*🚨

🖊️And it's live....

🌟The first of three releases today - a two-footed lunge at Forest. Plus much more, including those pesky Xmas viruses.

➡️ 9320-newsletter-b2f7c6.beehiiv.com/p/the-93-20-...

Tottenham attacker Brennan Johnson has completed his £35m move to Crystal Palace and is set to be available for the clash versus Newcastle on Sunday. (Sami Mokbel)

And also this👇

Mateo Kovacic is set for further surgery on an Achilles injury with a February/March return expected.

[Jack Gaughan, MailSport]

I get being upset with the decision from a fan perspective, do think it could’ve gone either way but it’s not like it was the last kick of the game, if an offside goal in the first half was the only way they saw themselves getting back into it then you can’t say the better side didn’t win

Plan to defund northern Utah library sparks backlash in packed council meeting Cache Valley residents packed a council hearing to speak out against a proposal to defund the county library.

Cache Valley residents packed a council hearing to speak out against a proposal to defund the county library.

Significant risk of harm, no clinically proven benefits in the real world. There is actually a somewhat elevated risk of worsening heart failure, infarc. You know those muscle pains, that stiffness? Did the doctor school you Rhabdomyolysis ?

🚨*𝗖𝗢𝗠𝗣𝗘𝗧𝗜𝗧𝗜𝗢𝗡 𝗧𝗜𝗠𝗘*🚨

📘To celebrate the release of a great new City book, author @domfarrell.bsky.social is giving away two copies of Glory Days for the Waifs and Strays.
One on X, one on Bluesky.

To enter, ensure you are following us and Dom, and repost this message

Good luck!

The injury list at Manchester City is dwindling. The injury list at Manchester City is dwindling. Only two players are unavailable for City's match against Villarreal.

Rodri and Abdukodir Khusanov are the only two players ruled out of Manchester City's clash with Villarreal due to injury.

esteemedkompany.com/2025/10/21/t...

I wish there were some new episodes, but I understand that things like this have a season, and that you might never do more. And that's okay. Just know that there's an old lady in the US who is your biggest fan.

Thanks again so much!

Best wishes to you and your dear family. 🩵✌️

@lorinclarke.bsky.social
So happy to see you here because now I get to thank you for The Fitzroy Diaries. I found your show in 2018. I was going through some stuff at the time, and The Fitzroy Diaries became a delight and a comfort to me. I've been listening on repeat ever since.

The guy who shot up #CDC wasn't a one off.
He was the nutcase predicted, nay, expected, from a long, tired anti-science campaign that demonizes the very people who try to help.

Honeybee the tabby cat is missing in western Loudoun County Virginia.

Western Loudoun county (VA)
Honeybee escaped at House Paws in Lovettsville. Once she calms down she will come to anyone, esp for food. Please keep eye open for her. Pink collar and chipped.

If you find her or see her reply here or message me. I will contact her family.

I teach 1st grade at a title one school and I absolutely💗it. I would love your help with pencil boxes for my students who come to school without one🥹

Any help is truly appreciated 💜

Thank you🥹
www.amazon.com/hz/wishlist/...

Today is the Community Shield final! The FA Cup winners against the Premier League winners.
Crystal Palace vs. Liverpool

Chronic illness tips:
- if we say we feel great, we feel fine
- if we say we're fine, we feel sick
- if we say we feel sick, we're really fuckin sick

Rodri tshirts now available

Cheers Blues!!!

(Amanda)
So the big day is here at last - Followers Day!

I hope everyone enjoys it, I know that Betty, Colin and Pip will.

Betty says she will take photos and share them tomorrow.

See you in the morning!

Here’s a structured summary of the main findings and insights from the article “A methylation clock model of mild SARS‐CoV‐2 infection provides insight into immune dysregulation” published in Molecular Systems Biology: ________________________________________ 🧬 Key Findings 1. Persistent Epigenetic Changes After Mild SARS-CoV-2 Infection • Both asymptomatic and mildly symptomatic infections induce similar DNA methylation changes, even when gene expression returns to baseline. • These methylation changes persist for months, resembling patterns seen in autoimmune and inflammatory diseases. 2. Methylation Clock Model • Researchers developed a machine learning model using methylation data to: o Distinguish between pre-, during-, and post-infection states. o Accurately predict time since infection. • The methylation clock revealed distinct temporal clusters of methylation changes, each associated with specific immune cell types and transcription factors. 3. Anti-Protective Epigenetic State • Contrary to the concept of trained immunity, the post-infection methylation state was found to be anti-protective: o Individuals with a pre-infection methylation pattern resembling the post-infection state had higher viral loads and worse outcomes. o This state was not induced by BCG vaccination, suggesting it is distinct from known protective epigenetic responses. ________________________________________ 🔍 Comparative Insights 4. Overlap with Other Diseases • The post-SARS-CoV-2 methylation signature showed significant overlap with: o Systemic Lupus Erythematosus (SLE) o Chronic infections (e.g., HIV, Hepatitis C) • No significant overlap was found with asthma, allergies, or tuberculosis. 5. Age and Epigenetic Vulnerability • The post-infection-like methylation state increased with age, suggesting cumulative immune challenges may predispose individuals to less effective viral suppression. ________________________________________ 🧠 Conceptual Implications 6. Epigenetic Memory o…

Even mild or asymptomatic SARS-CoV-2 infections can leave a lasting imprint on the immune system—one that may resemble patterns seen in autoimmune diseases and chronic infections.

This challenges the assumption that recovery from mild illness is complete.
www.embopress.org/doi/full/10....

Few originals available.
Anyone interested can DM me.