Wren

Significant risk of harm, no clinically proven benefits in the real world. There is actually a somewhat elevated risk of worsening heart failure, infarc. You know those muscle pains, that stiffness? Did the doctor school you Rhabdomyolysis ?

🚨*𝗖𝗢𝗠𝗣𝗘𝗧𝗜𝗧𝗜𝗢𝗡 𝗧𝗜𝗠𝗘*🚨

📘To celebrate the release of a great new City book, author @domfarrell.bsky.social is giving away two copies of Glory Days for the Waifs and Strays.
One on X, one on Bluesky.

To enter, ensure you are following us and Dom, and repost this message

Good luck!

The injury list at Manchester City is dwindling. The injury list at Manchester City is dwindling. Only two players are unavailable for City's match against Villarreal.

Rodri and Abdukodir Khusanov are the only two players ruled out of Manchester City's clash with Villarreal due to injury.

esteemedkompany.com/2025/10/21/t...

I wish there were some new episodes, but I understand that things like this have a season, and that you might never do more. And that's okay. Just know that there's an old lady in the US who is your biggest fan.

Thanks again so much!

Best wishes to you and your dear family. 🩵✌️

@lorinclarke.bsky.social
So happy to see you here because now I get to thank you for The Fitzroy Diaries. I found your show in 2018. I was going through some stuff at the time, and The Fitzroy Diaries became a delight and a comfort to me. I've been listening on repeat ever since.

The guy who shot up #CDC wasn't a one off.
He was the nutcase predicted, nay, expected, from a long, tired anti-science campaign that demonizes the very people who try to help.

Honeybee the tabby cat is missing in western Loudoun County Virginia.

Western Loudoun county (VA)
Honeybee escaped at House Paws in Lovettsville. Once she calms down she will come to anyone, esp for food. Please keep eye open for her. Pink collar and chipped.

If you find her or see her reply here or message me. I will contact her family.

as a person with ME/CFS, the part of this disease that I think should be the number one priority in research is PEM. it's the reason we're as disabled as we are.

without understanding and effectively managing post-exertional malaise, every other treatment / intervention falls short.

#NEISvoid

I teach 1st grade at a title one school and I absolutely💗it. I would love your help with pencil boxes for my students who come to school without one🥹

Any help is truly appreciated 💜

Thank you🥹
www.amazon.com/hz/wishlist/...

Today is the Community Shield final! The FA Cup winners against the Premier League winners.
Crystal Palace vs. Liverpool

Chronic illness tips:
- if we say we feel great, we feel fine
- if we say we're fine, we feel sick
- if we say we feel sick, we're really fuckin sick

Rodri tshirts now available

Cheers Blues!!!

(Amanda)
So the big day is here at last - Followers Day!

I hope everyone enjoys it, I know that Betty, Colin and Pip will.

Betty says she will take photos and share them tomorrow.

See you in the morning!

Here’s a structured summary of the main findings and insights from the article “A methylation clock model of mild SARS‐CoV‐2 infection provides insight into immune dysregulation” published in Molecular Systems Biology: ________________________________________ 🧬 Key Findings 1. Persistent Epigenetic Changes After Mild SARS-CoV-2 Infection • Both asymptomatic and mildly symptomatic infections induce similar DNA methylation changes, even when gene expression returns to baseline. • These methylation changes persist for months, resembling patterns seen in autoimmune and inflammatory diseases. 2. Methylation Clock Model • Researchers developed a machine learning model using methylation data to: o Distinguish between pre-, during-, and post-infection states. o Accurately predict time since infection. • The methylation clock revealed distinct temporal clusters of methylation changes, each associated with specific immune cell types and transcription factors. 3. Anti-Protective Epigenetic State • Contrary to the concept of trained immunity, the post-infection methylation state was found to be anti-protective: o Individuals with a pre-infection methylation pattern resembling the post-infection state had higher viral loads and worse outcomes. o This state was not induced by BCG vaccination, suggesting it is distinct from known protective epigenetic responses. ________________________________________ 🔍 Comparative Insights 4. Overlap with Other Diseases • The post-SARS-CoV-2 methylation signature showed significant overlap with: o Systemic Lupus Erythematosus (SLE) o Chronic infections (e.g., HIV, Hepatitis C) • No significant overlap was found with asthma, allergies, or tuberculosis. 5. Age and Epigenetic Vulnerability • The post-infection-like methylation state increased with age, suggesting cumulative immune challenges may predispose individuals to less effective viral suppression. ________________________________________ 🧠 Conceptual Implications 6. Epigenetic Memory o…

Even mild or asymptomatic SARS-CoV-2 infections can leave a lasting imprint on the immune system—one that may resemble patterns seen in autoimmune diseases and chronic infections.

This challenges the assumption that recovery from mild illness is complete.
www.embopress.org/doi/full/10....

Few originals available.
Anyone interested can DM me.

YouTube video by KeystoneSymposia Long COVID Meeting Promo

THE Long COVID meeting of the year is coming up! 🧬 Join us Aug 10–13 in Santa Fe, NM for Keystone Symposia on Long COVID & Post-Infection Syndromes.

Hear from experts on clinical + translational research, emerging treatments, and more.

🔗 keysym.us/KSLongCOVID26

youtu.be/6CsDkIaTBEY #KSLongCOVID26

@wren1113.bsky.social Hey, I will be teaching 4th grade Math & Science for the 1st time. I'll have 2 classes with 56 plus kids in a Title 1 school. We go back in 1 week. Even a share helps. 4 items until I clear the list! Thank you!❤️

www.amazon.com/hz/wishlist/...

YouTube video by FC Bayern München Thank you, Thomas Müller! | 𝐓𝐡𝐞 𝐎𝐫𝐢𝐠𝐢𝐧𝐚𝐥 𝟐𝟓™️

If you haven’t seen it yet, FC Bayern’s Thomas Müller doc is worth the watch. youtu.be/0io6km2htiA?...

Luis Diaz close to joining Bayern Munich in a €75million deal. (James Pearce)

Tanuvasa transfer adds fuel to BYU-Utah rivalry, but Kyle Whittingham keeps it cool Rivalry talk and a rebrand at the U.: Our Ute beat writer breaks down the latest Utah football news in this week's newsletter.

Rivalry talk and a rebrand at the U.: Our Ute beat writer breaks down the latest Utah football news in this week's newsletter.

If you have the AUDACITY to play video games on "easy" or "story" mode...

I want you to know that I think that's a perfectly acceptable way to enjoy a video game that you paid for because you're supposed to enjoy your favorite pastime any way you like.

Real life's hard enough. Enjoy your hobby.👍

Daniel Lawson @DanielLaw1998: Disabled parking should only be valid during business hours 9 to 5, Monday to Friday. I cannot see any reason why people with genuine disabilities would be out beyond these times. Jennifer Lee Rosman @JenLRossman: We’re disabled, Daniel, we’re not werewolves

7 years later and I still whisper, “We’re disabled, Daniel, not werewolves” to myself like a sacred mantra whenever I see a non-disabled person discover ableism like it’s the latest hipster indie band.

Oh hell!

There’s a summer COVID surge called the “nimbus variant.” I don’t know who comes up with these names, but if you’re sick, please stay home.

Razor‑blade throat: standout symptom—feeling like razor blades or broken glass. It’s often extremely painful when swallowing.

YouTube video by Michelle Obama Question 15: Guess who’s been our favorite guest so far? 👉 Barack Obama 🥰

Understanding how this country went from THIS level of intelligence, decency, integrity, and excellence to what we have now, is going to take decades to unravel.

Forever POTUS and FLOTUS

The NHS clinic supporting long Covid patients A specialist clinic is supporting thousands of people with the misunderstood condition.

BBC: ''Long Covid patients feel invisible and left behind''

'When the coronavirus pandemic took hold in 2020, few could have predicted the number of people who would suffer long-term effects. For some, the condition persists for years.'

www.bbc.com/news/article...

She is still waiting, not a single app for this incredibly silly, sweet baby girl. Here’s some new pics to share around!

Dangerous psychologiser Simon Wessely has a new patient group in his sights: trans kids The NHS has appointed psychiatrist Simon Wessely as chair of the new Children and Young People’s Gender Dysphoria Research Oversight Board

@thecanaryuk.bsky.social reports on @transsafety.network’s investigation into abuses of power in contrived authority practices in medical contexts involving Simon Wessley.

It seems to me that he gets appointed to medical CA groups because he gives politicians the answers they want.

This arrogant monster, who's done immense harm to people with ME/CFS, should not be allowed ANYWHERE NEAR trans kids.

His career was built by preying on the vulnerable and ignoring actual science (for which he received a knighthood). I can only imagine the damage he'll do to the trans community.