Mark James Adams

It's not every day that you get a new imputation reference panel.

allofus-anvil-imputation.terra.bio

Cameron Patrick - Some Quarto PDF formatting tips, with particular reference to thesis writing I’ve just spent most of a day faffing around trying to get Quarto to produce a nice PDF file that I like the look of and which meets my university’s formatting requirements for a PhD thesis. Maybe my ...

This is how I integrate Quarto and Zotero with minimal suffering (long rambling post, scroll down to the section on bibliography or search for Zotero): cameronpatrick.com/post/2023/07...

🚨 Position Alert! 🚨
I am looking for a full-time Research Scientist 1 to join my lab in Albuquerque, NM at the Center on Alcohol, Substance Use, and Addiction (CASAA). We will be studying how stress and trauma influence cannabis and substance use. 🧠🌿 (1/5)

Non-paywalled link to my commentary on @vw1234.bsky.social and colleagues new paper in @nature.com rdcu.be/eI2NG

University of Colorado Boulder Department of Psychology & Neuroscience is searching for TWO tenure track assistant professors. This is open to all department areas, including Behavioral, Psychiatric, and Statistical Genetics🧬 jobs.colorado.edu/jobs/JobDeta...

'Is artificial intelligence a scientific study?'
'Not really…'

— Muriel Spark, Symposium, 1990

Direct effect of genetic ancestry on complex traits in a Mexican population Human populations differ in disease prevalences and in average values of phenotypes, but the extent to which differences are caused by genetic or environmental factors is unknown for most complex trai...

Brilliant paper by Visscher et al.

Populations differ in traits/disease burden. Are these differences due to genetics?

Comparing single variants or polygenic scores between populations is biased due to environmental confounders correlated with the variants.

1/3

www.medrxiv.org/content/10.1...

Photograph of a presenter at a wooden podium in front of a slide with the question "Why Scotland" and bullet points "Top quality health research " and "Long standing, high quality health, social, and demographic data"

Photograph of a speaker at a podium in front of a slide showing the Generation Scotland Executive Committee ("Gang of Four")

At a symposium celebrating the 20th year of the @genscot.bsky.social cohort. David Porteous giving an overview of the origins of the cohort, answering the question "Why Scotland"

We're looking at setting up a trusted research environment (TRE) for our cohort, to enable observability and governance, smooth rollout of updates, limit proliferation of outdated copies.

Need some pointers on how to provision these environments up so that they aren't exasperating to researchers.

YouTube video by Brògeal Go Home Tae Yer Bed - Brògeal [Acoustic Video]

Good evening from Scotland.

Go Home Tae Yer Bed [Fhalbh Dhachaigh Don Leabaidh Agad] — Brògeal feat. Josie Duncan

youtu.be/__ezRGsYsuo

Playing screen for "I Am Not a Robot" by Marina and the Diamonds with the cover art from the album "The Family Jewels"

<Me clicking a reCaptcha checkbox>

tskit_arg_visualizer: interactive plotting of ancestral recombination graphs Summary: Ancestral recombination graphs (ARGs) are a complete representation of the genetic relationships between recombining lineages and are of central importance in population genetics. Recent brea...

Excited to share our new preprint for the tskit_arg_visualizer Python package! ARGs can sometimes feel like a black box, so
@yanwong.bsky.social and I have been developing a method to programmatically drawing these graphs.

🔗 arxiv.org/abs/2508.03958

1/6

Energy Homeostasis in Depression Pathophysiology and Heterogeneity This study examines whether the genetic liability of metabolic, interoceptive, and motivational pathways involved in energy homeostasis regulation is associated with specific symptoms of major depress...

Our study in @JAMAPsych ja.ma/4lVx1eu Using 🧬 we found that disruptions in #energy pathways link to specific #MDD symptoms (⬆️ appetite & sleep). This suggests a #depression profile linked to #metabolic risk, opening doors to targeted treatments. #metabolicpsychiatry

In Lilongwe for the kick-off meeting of the Genetics of Anxiety in Malawi project. Toward African-led, context-specific genomic research, supported by @wellcometrust.bsky.social

Meeting at the Kwaza Arts centre.

"Behavior drives morphological change during human evolution"

Our new article is out in @science.org today

www.science.org/doi/10.1126/...

Thanks! This is amazing! So the term 'Manhattan Plot' is not originally a GWAS term at all.

Screenshotting the image here from a 1994 book on nuclear physics, for others who may be interested:

Edinburgh University had ‘outsized’ role in creating racist scientific theories, inquiry finds Investigation finds one of Britain’s oldest and most prestigious universities benefited from transatlantic slavery and was haven for white supremacist theories

www.theguardian.com/education/20...

Review of Race and History | The University of Edinburgh The academically-led review explores historic racial and colonial injustices, including enslavement, linked to the University as well as reassessing current policies and procedures.

The University of Edinburgh has published its Race Review.

The report goes way deeper than just ties to slavery: "…the UoE formed a central point in a network of knowledge about 'civilization' and 'race' from the period of the Enlightenment onward."

www.ed.ac.uk/about/race-r...

In #GENETICS, Williams et al. present a novel statistics—haplotype score—for summarizing identity-by-descent (IBD) sharing that can distinguish half-sibling pairs from avuncular or grandparent-grandchildren pairs and assign individuals to ancestor vs descendant generation.

buff.ly/SaZP3CA

Guidance discusses bias and inaccuracy, and potential harms to your own learning capacity, society, and the planet.

I like the idea that if you use generative AI, you need to include your prompts in an appendix.

Using generative AI in your studies: guidelines for students | Computing | Information Services • The University trusts you to act with integrity in your use of generative AI for your studies. • It does not ban the use of generative AI, though its use is restricted for assessment. • Some of your...

My university has new guidance about generative AI. Requirements and restrictions are set on a course-by-course basis, but AI outputs must not be presented as a student's own work and the exact use must be acknowledged.

information-services.ed.ac.uk/computing/co...

If you are new to GWAS, the lectures by Matti Pirinen are a good place to start. Conceptual foundations rather than how to use software.

www.mv.helsinki.fi/home/mjxpiri...

Very happy to share our new paper now on @medrxivpreprint: “Genetic risk effects on psychiatric disorders act in sets”, a great effort led my PhD student @jolienrietkerk.bsky.social, and performed together with collaborators Andy Dahl, Jonathan Flint, Andrew Schork etc. Thread 1/n

🧬 New @emblebi.bsky.social service beta launched:
Perturbation Catalogue

🔎 Browse genetic perturbation datasets
🧠 Train models
🧬 Interpret variant function
🧭 Explore gene dependencies

Search, test APIs, suggest datasets, send feedback!
🔗 www.ebi.ac.uk/perturbation...

Funded by @opentargets.org

This work is now officially published! Little has changed, but with added analysis to further support our original claim!

bsky.app/profile/ajhg...

"Whereas the Buildings in the University of Edinburgh are extremely mean and inconvenient, some of them in a very ruinous condition, and all of them unsuitable to the flourishing state of that Seminary of Learning…; and whereas a PLAN for building a NEW UNIVERSITY has been prepared by Robert Adam"

Cover of the book. Title and author name in white serif text on the green background with a small inset black & white photograph of Regent Terrace

Old College, University of Edinburgh, eastern part of the quadrangle with a dome.

Reading about the plan for the "NEW UNIVERSITY" building in Edinburgh, built in the 1790s but now called "Old College".

A. J. Youngson, The Making of Classical Edinburgh.

Come join us! We have an exciting PhD opportunity in statistical genetics at the University of Oxford.
More info here: bit.ly/biomedDPhil
🗓️ App deadline: June 30th 2025.
Please share!

Is there a quantitative genetics/evolutionary biology conference happening in Europe between Dec 2025 - April 2026?