Ariel Levine

Hello lab!! It’s been six weeks of shutdown, so much chaos and loss. But today, I am deeply happy to feel a slice of normal, to see my team and our community, and do some science

@runewberg.bsky.social congrats Rune and team! This looks really cool

3 Postdoctoral Research Fellows Champalimaud Foundation (Fundação D. Anna de Sommer Champalimaud e Dr.

🚨Job alert🚨

The lab has up to *3 postdoc openings* for comp systems neuroscientists interested in describing and manipulating neural population dynamics mediating behaviour

This is part of a collaborative ARIA grant "4D precision control of cortical dynamics"

euraxess.ec.europa.eu/jobs/383909

A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences The spinal cord is the gateway for sensory information from the body as it ascends to the brain, as well as a major motor output center of the nervous system. It is also a key location for sensory-mot...

The latest work from our PRECISION Human Pain Center project is now up on @biorxivpreprint.bsky.social led by Katherin Gabriel and @oliviadavis.bsky.social with a huge contribution from @allanhpool.bsky.social's lab and, of course, the Southwest Transplant Alliance: www.biorxiv.org/content/10.1...

Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding The formation of neural circuits depends on the precise spatial and temporal organisation of neuronal populations during development. In the vertebrate spinal cord, progenitors are patterned into mole...

Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social

We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇

www.biorxiv.org/content/10.1...

🧠🌟🐭 Excited to share some of my postdoc work on the evolution of dexterity!

We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵

High-resolution in vivo kinematic tracking with customized injectable fluorescent nanoparticles Injectable fluorescent nanoparticles were used to track positions on and inside of freely moving animals at high resolution.

Our first preprint has been accepted for publication www.science.org/doi/10.1126/... !!
tldr: @ezeyulu00.bsky.social , @amartyapradhan.bsky.social , @dkoveal.bsky.social and I developed a method using injectable nanoparticles to turn mice into…constellations in motion. 🧵⤵️

Congrats, Jeff! I can’t wait to try it out

Sabbatical question - which activities do you keep up and which do you pause?

Eg reviewing new papers and grants, non-mentorship related service committee meetings, normal schedule of lab meetings…

Yes I hope so! And thanks :)

Do you know of a third color that can be added to cyan and orange and for which the paired with overlaps are different? Thank you!

Agreed! But do any of these work for 3 color overlap analysis on a black background? For example, in RGB, we’d want to distinguish between R+G yellow vs R+B purple. But make it colorblind friendly

Does anyone have favorite colors for color blind friendly fluorescence images on a black background where the overlap combinations of 3 colors are important?

Magenta/cyan/yellow overlaps are difficult to distinguish (lots of white)

Thank you!

Was so nice to meet you!

Compositional neural dynamics during reaching The complex mechanics of the arm make the neural control of reaching inherently posture dependent. Because previous reaching studies confound reach direction with final posture, it remains unknown how...

Excited to share my latest work with @jonathanamichaels.bsky.social @diedrichsenjorn.bsky.social & @andpru.bsky.social!
We asked: How does the motor cortex account for arm posture when generating movement?
Paper 👉 www.biorxiv.org/content/10.1...
1/10

Cool! Yes I saw the one walking task but wished for more ;) also, re posture, I meant to include it as a background context for other behaviors/tasks (a conducive/natural posture vs arbitrary/atypical)

Anyway, I’m really intrigued to see how this develops!

Also very curious about modeling of an overall “postural” component and more whole body/lower limb driven behaviors

Congrats! It’s a little far from my wheelhouse but this seems like a fantastic way to approach the “problem”.

Is there a way to build up a layered model that mimics vertebrate evolution to see if that improves finding more universal (vs task specific) representation?

Nice work, Remi and team!

Super cool!

@petrznam.bsky.social this is so cool!

1/N
How do neural dynamics in motor cortex interact with those in subcortical networks to flexibly control movement? I’m beyond thrilled to share our work on this problem, led by Eric Kirk @eric-kirk.bsky.social with help from Kangjia Cai!
www.biorxiv.org/content/10.1...

The spinal premotor network driving scratching flexor and extensor alternation Yao et al. developed a neuromechanical model based on experimental perturbations, aligning theory-predicted with genetically labeled cell types. This work highlights the importance of inhibitory inter...

Paper is finally out on our experimentally-driven neuromechanical model to explain how spinal inhibition makes you do things faster! www.cell.com/cell-reports...

🧿 Excited about molecular biology & genetics 🧬🧬🧬? Wanna live in Paris? Join our team as a lab manager under the supervision of @kevinfidelin.bsky.social & myself! Personal development in professional environment is our mission. Inclusive space where proactive and playing collective people flourish 🧿

🥳 wooohooo! Congrats and so well deserved!

Despite some ups and downs at NIH, we do have an open position for a postbac and are considering candidates.
Our work is at the intersection of neuroscience and AI, and we aim to understand how the brain's densely connected recurrent networks operate. 🧪

Todd is a fantastic scientist, mentor, colleague and friend. Highly recommend!!

Congrats, Alex and team 🥳 This is amazing!!

So now you’re just dropping cool papers every week?

Our PhD student Louis Romette is optimizing long-term live-cell imaging. He just casually dropped this 65-hour movie of a growing neuron (div 3 to 6) with knocked-in actin 🔥🕶️ #realtimemicroscopy

Electric excitability of the cerebrum (Uber die elektrische Erregbarkeit des Grosshirns) - PubMed Electric excitability of the cerebrum (Uber die elektrische Erregbarkeit des Grosshirns)

Well, turns out that’s just how they did it way back when. Fritsch and Hitzig in 1870 through at least some 1906 Sherrington

pubmed.ncbi.nlm.nih.gov/19457461/

pubmed.ncbi.nlm.nih.gov/16992835/