Priyom Adhyapok

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4-panel comic. (1) [person in front of window, shaped like a trapezoid with a curved top] This weekend, I had to make an oversized screen for a porch window. (2) [person sitting with hands on head surrounded by images of assorted equations and measurements] It involved countless tiny problems, each somehow way harder than it should be. Oblique angles. Curved edges. Noncoplanarity. (3) [person in front of window with screen on it, with building detritus strewn on the ground] ...I solved them all. I measured precisely. I did trigonometry. I made custom parts. And it fit *perfectly.* No gaps, no ripples. (4) [person typing at computer] I know that your foundation normally limits its purview to physics, medicine, peace, chemistry, and literature. However, if you review the attached photos showing how well the screen fits into the...

Window Screen

xkcd.com/3151/

The Secret to a Smooth Pasta Sauce Wins Ig Nobel Prize Italian researchers studied how the ingredients of the traditional Roman dish cacio e pepe emulsify into a creamy sauce, winning the 2025 Physics Ig Nobel Prize.

Truly chuffed for our fearless food physicists @mpipks.bsky.social + collabs from AT @istaresearch.bsky.social, IT & ES who won this year’s Ig Nobel - the #NobelPrize of hearts❤️for cracking the science of perfect pasta !🍝Kudos to all for intrepidly consuming lots of cheese in the name of science!😋

Comic. [Building with large sign in front of it[ SIGN: Welcome to the *Biology Department* It has been [changeable sign: 3] days since we discovered something existentially horrifying about bugs that makes you question your whole reality

Biology Department

xkcd.com/3140/

“Duke University School of Medicine” logo above a line with “Discovery AI” logo

Duke is recruiting a tenure-track Assistant Professor in AI/ML for Biology—joint Discovery AI Initiative × Cell Biology Search. Building models for protein design, single-cell/spatial omics, imaging, proteomics, genomics? Apply: academicjobsonline.org/ajo/jobs/30509
#hiring #AIforBio #CompBio

Thank you to my two amazing mentors @bagnatlab.bsky.social, @ditalialab.bsky.social and co-author James Norman. Excited to hear your thoughts!

(8/n) To decode the circuit components, we use genetics to show the increasing expression of Egf ligand near the bifurcation. We propose negative feedback required for the oscillations is provided by the transcription of spry and dusp

(7/n) We show that the first cycle is slower and built a simple mathematical model to understand how an oscillatory circuit can generate different frequencies following a bifurcation

(6/n) We found interesting features of the oscillations. Remarkably, oscillators are very synchronized. We map emergence of synchronicity and the first oscillation cycle

(5/n) This provides an example of how biology uses oscillators as timers to generate periodic patterns!

(4/n) 4) These oscillations result in periodic increases in the expression of segmentation pathway genes, allowing induction and maturation of cells to build segments

(3/n) We found that the notochord cells display intra-cellular Erk oscillations of around 10 hours

(2/n) We wanted to investigate what controlled the pace at which segmentation proceeded

(1/n) The zebrafish notochord slowly builds the vertebral column of the spine over ~ 2 weeks through a process of molecular segmentation (=division of tissue into units)

Building a spine is no joke, but thankfully zebrafish have their own clocks to keep the pace. Excited to share our preprint on the role of biological oscillators in coordinating notochord development! (www.biorxiv.org/content/10.1...)
Additional thread below

Thank you for the support! @febsletters.bsky.social

From genes to patterns: five key dynamical systems concepts to decode developmental regulatory mechanisms Summary: Dynamical systems theory provides a powerful quantitative and intuitive framework to understand developmental processes. This Primer brings key concepts of this framework to the ever-growing ...

5 dynamical systems concepts every developmental biologist needs to know! This came out of the 2023 Morphogenesis Program. @pauformosa.bsky.social ‪@perez-carrasco.bsky.social‬
journals.biologists.com/dev/article/...

Please spread the word!
We are looking for postdoc(s) interested in quantitative problems in Development and Regeneration. Previous experience in quantitative biology is not required. We will support you and provide a great training environment if you are committed to learn new things.