Scott Marek

Inter-individual variability of neurotransmitter receptor and transporter density in the human brain | doi.org/10.1007/s004...

How do neuroreceptor distributions vary across people?

🚨 New preprint: Objective Quality Assessment for Precision fMRI

Precision functional mapping (PFM) enables individual-level brain network studies — but demands more, and better, data.

We introduce an objective framework to determine when a dataset truly supports interpretable, replicable PFM.

This complex brain network may explain many of Parkinson's stranger symptoms Parkinson's disease appears to disrupt a brain network involved in everything from movement to memory.

Parkinson's disease appears to disrupt a brain network involved in everything from movement to memory. n.pr/4kpKWtv

I’m very excited about this new work describing the specific cortical-striatal circuits that are altered in Parkinson’s Disease and that should be targeted for optimal PD treatment.

www.nature.com/articles/s41...

Check out our new work on the relationship between glioma and system-level functional networks! We identify that nearly all gliomas localize within a common brain functional network, Action-Mode Network (AMN) .

biorxiv.org/content/10.64898/2026.01.05.697608v1

Benjamin, why do I suspect that this will not be the last time we see this pattern?…

This is your brain on Ritalin. Got your attention? Stimulant medications like Ritalin (methylphenidate) do, but not in the way you might think. They don't act directly on the brain’s attention systems! Find out what's really happening in @cellpress.bsky.social. doi.org/10.1016/j.ce...

Ever wondered if your interesting brain-behavior correlation was over- or under-estimated due to head motion, but were afraid to ask? We’ve created a motion impact score for detecting spurious brain-behavior associations, now available in Nature Communications!
doi.org/10.1038/s414...

I would love to know the real reason(s) why

I still get chills

Meet Mike
*30+ years severe depression
*first hospitalized @ 13y
*20 meds
*3 rounds of ECT
*2 near-fatal suicide attempts

Mike felt joy for the first time in decades after we turned on his new brain pacemaker or PACE

see videos, read paper, follow thread
doi.org/10.31234/osf...

I’ve yet to receive a PFM grant.. perhaps the era is not yet over @rodbraga.bsky.social 😅

1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social

AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements...

doi.org/10.1038/s415...

Alert!!!!

“An Action Networks Model for Pain”

We propose a new model for chronic pain — and highlight two functionally connected cortical networks that could revolutionize how we treat it.

👉 thread below 🧵

osf.io/preprints/ps...

My med school textbook says stimulants like Ritalin treat hyperactivity by “stimulating” the brain’s attention and cognitive control systems. We studied children taking stimulants in the ABCD Study, and the largest differences were actually in arousal and reward networks! Check out our preprint!

It's shocking how little is known about the brainstem red nucleus. In our new paper “The human brainstem’s red nucleus was upgraded to support goal-directed action” out now in @naturecomms.bsky.social we show that current thinking on the red nucleus is in need of a serious upgrade. rdcu.be/ehbOy

Good on you for not taking him. He’s so mid along with every other contemporary right wing “noticer”.. Sailer, Yarvin, I/O, etc.

Would love to be added, such a cool idea!

Love to see this conversation starting!
"Study design features increase replicability in brain-wide association studies"

Full article led by Kaidi Kang and Simon Vandekar + awesome News+Views by @roselynechauvin.bsky.social & @ndosenbach.bsky.social!
👇
www.nature.com/articles/s41...

#neuroskyence