Kristiaan Wouters

New preprint! Liver macrophages are highly autofluorescent cells, complicating analysis. @sabinedaemen.bsky.social developed a spectral flow approach to resolve #macrophage subsets in healthy vs #MASLD livers.
#FlowCytometry #SpectralFlow #Autofluorescence
doi.org/10.64898/202...

Circulating Neutrophil and Monocyte Counts Are Inversely Associated With Heart Rate Variability Indices: The Maastricht Study | Journal of the American Heart Association

Happy to share our latest publication showing that higher neutrophils and monocytes, but not other leukocytes, were linked to lower heart rate variability — a sign of reduced flexibility in how the heart responds to daily demands.

www.ahajournals.org/doi/10.1161/...

#inflammation #cardiovasular

Frontiers | Pyridoxamine reduces inflammatory and microcirculatory abnormalities in metabolic dysfunction-associated steatohepatitis and modulates key factors in the hepatic AGE/ALE signaling pathway Metabolic dysfunction-associated steatohepatitis (MASH) is an increasing public health concern for which new therapies are urgently needed. As growing eviden...

📄 New paper published in Frontiers in Physiology!

We show that pyridoxamine reduces inflammation and microcirculatory dysfunction in MASH, modulating key hepatic AGE/ALE signaling pathways.

🔗 doi.org/10.3389/fphy...
#MASH #LiverDisease #Inflammation

At the dawn of 2025, I received the second notification this week of an accepted manuscript.

A wonderful way to close out 2025 and step into 2026 with renewed motivation and momentum.

I wish everyone a Happy New Year and all the very best for the year ahead!

Fetal liver #macrophages support red blood cell production and pyrenocyte clearance in the developing embryo. Stifter, Greter et al. demonstrate that XPR1, a phosphate exporter and regulator, is required for the development and function of fetal liver macrophages. rupress.org/jem/article/...

Hi Lizzy, great to find you back here on Bluesky! Just voted. Nice coincidence, we are also currently looking at inflammatory differences in MASLD development, after previously in obesity!

Today I presented our data on sex differences in experimental #MASH development at the MASLD-EGIR Study group meeting in Pisa showing earlier #steatosis, #inflammation and glucose intolerance in females but more fibrosis in males. Great conference! @gastaldelli-amy.bsky.social

Thrilled and honoured to chair the #VeniVidiVici session at #CARIMday2025! It's inspiring to see so many talented researchers achieving success in securing grants. Especially proud to serve as Chair of the Carim Research Council and witness this incredible progress! 👏🎉 @carimmaastricht.bsky.social

@sabinedaemen.bsky.social investigates how immune cells can repair liver fibrosis. A big step toward fighting one of the world’s most pressing metabolic diseases and emerging CVD risk factor.

#CARIMday2025 #MASLD #Veni

CARIM+HVC Symposium 2025 YouTube video by Maastricht University

Join now on www.youtube.com/live/17cD_lN... for our annual CARIM+HVC Symposium

@tilman-hackeng.bsky.social kicks off the #CARIMday2025. It will be a great day to celebrate #Cardiovascular research and working together.

At the #ADDRM, @sabinedaemen.bsky.social, postdoc in my group, presented her work on sex differences in a mouse model of #MASH, an area where most data still rely on male mice. She found sex-specific differences in hepatic steatosis, fibrosis progression, and glucose intolerance.👏🐭🔬

We hiring! Please share this post with your talented ECRs

We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome

Based at @lmcb-ucl.bsky.social at University College London

Apply here:
www.jobs.ac.uk/job/DPD418/r...

Kicked off the #EU-RESOLVE COST Action last week - a network advancing research on #inflammation #resolution
I co-lead WG5, building a Knowledge Hub on insights in resolution biology. We want this hub to grow, so join us and help shape this valuable resource!
www.cost.eu/actions/CA24138/

Kicked off the #EU-RESOLVE COST Action last week - a network advancing research on #inflammation #resolution
I co-lead WG5, building a Knowledge Hub on insights in resolution biology. We want this hub to grow, so join us and help shape this valuable resource!
www.cost.eu/actions/CA24138/

#thesisdefence Tomorrow, Sara D'Haese will defend the thesis 'Mitigating diabetic cardiomyopathy: Evaluating exercise training and pyridoxamine as cardioprotective approaches’ at 16:00h @maastrichtu.bsky.social @kwouters.bsky.social‬

📺 buff.ly/1VrmD4j
📖

#phdlife #phddefence #GradSchool #doctorate

Schwarzenegger: Hey, stop whining, do something on climate change The actor and activist was speaking to the BBC at a summit organised by his Climate Initiative.

What.A.Guy. Best advice and applicable to about everything. "Stop whining. What are You doing?" There will always be obstacles. @schwarzenegger.bsky.social www.bbc.com/news/videos/...

Inspiring presentation of Gemma Figtree at #EASCongress2025 on treating #atherosclerosis as a disease rather than traditional risk factors, especially considering that 25% of MI patients show none of them.

#EASCongress2025 kicks off with a bang. Paul Ridker gives the Anitschkow lecture on targeting #inflammation to target #atherosclerosis. #cardiovascular #CVD

The Biggest Lie About Weight Loss And Exercise YouTube video by Global Cycling Network

Kudos @GCN for a balanced analysis on claims that #exercise does not induce #weightloss: www.youtube.com/watch?v=vUGF...
As mentioned here (bjsm.bmj.com/content/59/2...) it's about adherence.
For me, first 20-25kg were dietary pattern changes (not dieting), the next few kg definitely exercise.

Happy to share our latest publication showing that adiposity differentially affects immune cells in fat depots based on #sex during #obesity development. rdcu.be/d36Dx. @lisatschuetz.bsky.social al @biekebroux.bsky.social roux.bsky.social
#immunosky

An Insight into the Role of IL-10 and Foamy Macrophages in Infectious Diseases Abstract. Dysregulation of lipid homeostasis causes the deposition of lipids in the form of tiny droplets within foamy macrophages (FMs). In FMs, host-deri

A review for those of us (me!) who only really know foamy macrophage in the context of cardiovascular pathology:
#immunology

journals.aai.org/jimmunol/art...