Patrick van der Wel

FYI: open for submissions - special issue “Martin Karplus: In Memoriam” in the @biophysicalsoc.bsky.social Biophysical Journal - deadline Nov 30th. See info: www.biophysics.org/Portals/0/BP... #biophysics

Now also here: @harutyunyanlab.bsky.social

Neutrons are the best ... look at this histidine-galactose contact !! Our new neutron structure of lectin/gal is available as preprint in ChemRXiv chemrxiv.org/engage/chemr.... Thanks to @drmpblakeley.bsky.social @sebvidalchem.bsky.social and all colleagues for very fine collaboration

Day two of #NWOBiophysics begins with Alexander Buell, talking about “What can we learn about intrinsically disordered proteins from mutagenesis studies?”

nwobiophysics.nl/programme/ke...

Almost ready for tonight’s keynote lecture at #NWOBiophysics , by Petra Schwille from the Max Planck Institute of Biochemistry: Design features of biochemical pattern formation #biophysics

I'm very grateful to have had the opportunity to present my group's work next to the big "biophysics" sign on the main stage at #nwobiophysics
(I'm also very happy that I didn't fall down the stairs)

2025 Nobel Prize in Physiology or Medicine #nobelprize

E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

The Nobel Assembly at the Karolinska Institutet has decided to award the 2025 Nobel Prize in Physiology or Medicine to Mary E. Brunkow Fred Ramsdell Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance”

Large mushroom. Maybe Imleria badia.

The good things are sometimes very close. Keep your eyes open.

Some rainy #running

Mark the date: colleagues at the @rug.nl are hosting a cool chemistry conference in Groningen next May. See here: gromochem.web.rug.nl/index.php

With speakers from various chemistry disciplines. Promises to be a nice event. (May 10-13 2026)

(I just hope the weather will be ok for the #wadlopen)

Looking forward to next week: the annual trip to the #NWOBiophysics symposium (in Veldhoven). nwobiophysics.nl #NWO With lectures by Alexander Buell, Petra Schwille, @biophysk.bsky.social and others! (expecting cool science on amyloids, lipids, and chaperones?)

The NWO Biophysics Conference is almost here—and we are bringing something new in gentle confocal microscopy!

Imagine a system that self-adjusts laser power for the best signal-to-noise ratio, no matter how deep you image, and enables you to set up your experiment in just minutes.

Trump attacks 9 universities: Sign the alumni petition to defend your school now Are you an alum outraged by Trump's attacks on universities? Defend your school now by signing this alumni petition in support of these 9 universities as well as campus communities across America.

I just signed this. Please consider do so as well.

alumni.controlshift.app/petitions/tr...

Meanwhile, at my current place of employment...

The Tip of the Week from our senior research leaders

Following the law is, of course, important, but the messaging through their choice of topics says a lot.

"What you do makes a difference, and you have to decide what kind of difference you want to make"

Promotional image for symposium with background image targeting a cell and the RSC logo. Text on image states: Chemical Science Symposium, 18-19 November 2026, London UK. Register by 20 October 2025.

This year's Chemical Science Symposium celebrates the chemistry of imaging, biosensing and diagnostics. Join us to explore cutting edge research from our international speakers and the 2025 Chemical Science Lectureship winner.

18-19 November 2025
London, UK, and online

www.rsc.org/events/d...

Ready to take the next step in your academic career?

The Amyloid Early-Career Reviewer Mentoring Program (2025–2027) is designed to guide emerging researchers through the peer review process, with mentorship and ongoing support from experienced reviewers and editors.
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Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging

www.biozentrum.unibas.ch/open-positio...

#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging

the abstract of the review

the schematic of a 3D printer

Our 6-hands review/perspective: "Hacking 3D printers as laboratory robots" is now on ChemRxiv.
In there, we show how many robots you can make by simply modifying a 3D printer. #chemsky 1/n

with @sandersays.bsky.social and @supersciencegrl.co.uk
chemrxiv.org/engage/chemr...

More info here: bsky.app/profile/pcav...

#NMRchat Probing photochemically-induced dynamic transitions by magic-angle-spinning NMR combined with in-situ irradiation http://pubs.rsc.org/en/Content/ArticleLanding/2025/TA/D5TA06364G

NB. Here are some more posts about this paper, now that it is published in its final form at the journal:

bsky.app/profile/pcav...

All in all, we hope that the information about the probe/methods can be useful to other #ssNMR groups interested in this topic. Moreover, we expect this approach to be useful for many other applications and studies, with some more of our own work coming…. #nmrchat #photochemistry #optogenetics

We can detect and follow dynamic changes upon the photo-switching of encapsulated azobenzene (in alginate hydrogels) as well as a UV hardening process. Crucially, samples were provided by our collaborators - @luzylein.bsky.social Wiktor Szymanski @lerchlab.bsky.social @feringalab.bsky.social !!

We leverage dynamically sensitive MAS NMR experiments with different polarization transfer techniques.

(See our 2018 review (doi.org/10.1016/j.ym... ), and more recent papers by Matthias Ernst ( @maer.bsky.social ) and Daniel Topgaard doi.org/10.1515/pac-... doi.org/10.1016/j.jm... )

Fast photochemical conversions suggest high illumination efficiency.

Then, we also show some applications to semi-solids and UV-hardening materials, where our special interest was in probing not only the chemical transformations by NMR, but also the dynamic changes that follow. …