James

Congratulations!

Looks like a nice resource:
* Array genetic data for 80,638 Japanese children
* 1,163 child health and developmental traits (e.g. food allergy, anthropometric, developmental)
* Parental environmental exposures

www.medrxiv.org/content/10.1...

If you missed the last ten years of behaviour genetics you can pretty much catch up on everything by reading all his blogposts.

What’s wrong with it?

Examining overlap and homogeneity in ASD, ADHD, and OCD: a data-driven, diagnosis-agnostic approach - Translational Psychiatry Translational Psychiatry - Examining overlap and homogeneity in ASD, ADHD, and OCD: a data-driven, diagnosis-agnostic approach

Diagnostic categories in mental health do not distinguish people or brains "Our results did not support the validity of existing diagnostic labels of ASD, ADHD, and OCD as distinct entities with respect to phenotype and cortical morphology." www.nature.com/articles/s41...

Are there any good blogposts or commentaries on the 2025 depression gwas?

Genome Editing and Eugenics The one hundred and third Take:

Thoughtful piece by Greg Gibson pushing strongly back on the "Heritable polygenic editing" article
genomestake.substack.com/p/genome-edi...

David Lynch as Gordon Cole in Twin Peaks

RIP, David Lynch. Truly one of the great weirdoes in film and television history.

Unironically yeah, long live David Lynch 🕊️

After the Green New Deal We need a clean energy strategy for a full employment economy

A Green New Deal makes sense if you’re in a recession, but a full employment economy needs a different approach to energy and prosperity.

www.slowboring.com/p/after-the-...

Article screenshot of a genome-wide association study of major depression published in the journal Cell

1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @cellpress.bsky.social.

www.cell.com/cell/fulltex...

A thread 🧵:

The Dimensional Turn in Psychopathology: Q&A with Robert Krueger Distinguished McKnight University Professor at the University of Minnesota

The Dimensional Turn in Psychopathology: Q&A with Robert F. Krueger

“Everything we try as a field ends up illustrating how murky and complex the origins of psychopathology tend to be.”

www.psychiatrymargins.com/p/the-dimens...

Most neurons in mouse cortex defy functional categories The majority of cells in the cerebral cortex are unspecialized, according to an unpublished analysis—and scientists need to take care in naming neurons, the researchers warn.

Who likes categories anyway?
I wonder what this means for the concept of "areas"...
#neuroscience
www.thetransmitter.org/neural-codin...

Wrong

After Kraepelin: Ambitions, images, Practices and the History of Psychiatry 1926-2026 This two-day event will review the ambitions, images and practices of psychiatry, as they have evolved during the period under review and seek pointers for continuity and transformation in the future.

Very glad to be invited at this Conference!
Royal Society of Medicine,6-7 March
"After Kraepelin: Ambitions, Images, Practices and the History of Psychiatry 1926-2026"
I'll discuss the role of social values and collective emotions in the making of Asperger diagnosis
www.rsm.ac.uk/events/psych...

YouTube video by Michel's Science Speedrun is this an accidental Podcast? Eiko Fried & Michel Nivard discuss a new GWAS of depression preprint

I tried this BTW but while I approached both men and women, and both groups considered it, the men took me up on the offer, or volunteered (which is great!!). I decided I am not going forward if I can’t keep balance… ( pls volunteer!). This chat with eiko last yr is what I have in mind, sorta…

Good resource. A well-written op-ed can sometimes end up as impactful as a full paper...

I’d definitely watch that, especially something on how valid Mendelian randomisation studies are for traits in which the gwas is pretty weak.

Truth nuke

Last work tweet of 2024 (maybe 😉): I, Ken Kendler, Brad Verhulst, @jorsmo.bsky.social and @andrewgrotzinger.bsky.social et al in the Psychiatric Genomics Consortium Cross Disorder Group (PGC-CDG) wrote a review on challenges studying cross disorder (psych) genetics: www.nature.com/articles/s41...

Relational neuroscience: Insights from hyperscanning research Humans are highly social, typically without this ability requiring noticeable efforts. Yet, such social fluency poses challenges both for the human br…

Now published (Neuroscience & Biobehavioral Reviews):

"Relational neuroscience: Insights from hyperscanning research"

We introduce #RelationalNeuroscience as a framework for research on inter-brain dynamics.

We state that #hyperscanning is the prime methodology informing Relational Neuroscience.

What happens to heritable conditions across generations? some counterintuitive properties of the polygenic liability threshold model

I wrote about how polygenic heritable conditions present in families and the liability threshold model. This has some counterintuitive implications for considering the risk of a condition in offspring as well as the impact of multi-generational selection. A 🧵:

Trout-in-the-milk level of uncertainty

Genomic network analysis characterizes genetic architecture and identifies trait-specific biology Pervasive genetic overlap across human complex traits necessitates developing multivariate methods that can parse pleiotropic and trait-specific genetic signals. Here, we introduce Genomic Network Ana...

You've heard of DNA, but what about GNA? Very excited about this preprint with @jgthorp.bsky.social and others that introduces Genomic Network Analysis (GNA), an open-source multivariate tool for performing network analysis using GWAS summary statistics as input. 1/2
www.medrxiv.org/content/10.1...

Within-Family GWAS does not Ameliorate the Decline in Prediction Accuracy across Populations As polygenic prediction extends beyond the research domain to involve clinical applications, the urgency of solving the "portability problem" becomes amplified -- that is, the fact that polygenic indi...

www.biorxiv.org/content/10.1...

Smart study to test whether lower prediction accuracy in non-Europeans is due to between-population differences in population structure, genetic nurture, or assortative mating.

Defund the healthcare

Pathway to terrorist behaviors: The role of childhood experiences, personality traits, and ideological motivations in a sample of Iraqi prisoners Radicalization to terrorism is a multifaceted process with no single theory or approach to explain it. Although research has focused on understanding the process, there is still a dearth of studies t...

onlinelibrary.wiley.com/doi/10.1111/...

Fluctuating number of fingers aside yeah