Dillon Corvino

The Junior PI call @ccii-kyoto.bsky.social is open until the end of the month.
Join us in Kyoto! 👇
#Immunology #Immunotherapy #Immunosky

Can’t access the paper as it’s behind a paywall. But isn’t much of this already described already. Or is the idea that these progenitors seed tissues and locally expand the novel insight?

Migrating immune cells globally coordinate protrusive forces @natimmunol.nature.com
www.nature.com/articles/s41...

NKG7 is a Stable Marker of Cytotoxicity Across Immune Contexts and Within the Tumor Microenvironment Cytotoxicity-associated genes exhibit heterogeneity at the cellular and tissue levels (left). NKG7 gene expression is strongly associated with a cytotoxic gene signature (middle). NKG7 expression is ...

🚨 New Paper in European Journal of Immunology!
We show that NKG7 is a robust marker of cytotoxicity, outperforming GZMB and PRF1 across immune cell types and tissues!
Thanks to all co-authors, @nsssusanna.bsky.social, @M.Hoelzel & @eomesodermin.bsky.social
📖 onlinelibrary.wiley.com/doi/10.1002/...

This would be a fantastic opportunity. What is the best way to contact you?

NKG7 is a stable marker of cytotoxicity across immune contexts and within the tumor microenvironment
www.biorxiv.org/content/10.1...
@eomesodermin.bsky.social @nsssusanna.bsky.social @rturiello.bsky.social

🚨 Job alert 🚨
1 PhD + 1 Technician
Our lab is looking for motivated candidates interested in understanding the impact of diets and lifestyle on tumor development, anti-tumor immunity and metastasis! Apply and join our team!
Info below 👇

🚨Open positions! The group of Laura Surace from the University Hospital Bonn is looking for a

🧑‍🔬 PhD student in metabolic regulation of tissue-resident immune cells during metastasis

🧑‍🔬 and a Technical Assistant

Application Deadline is March 31!

#job #science #PhD #immunology #openposition

icCITE-seq (intracellular cellular indexing of transcriptomes and epitopes), a scalable method that simultaneously measures surface and intracellular protein levels alongside gene expression across thousands of cells
doi.org/10.1101/2025...

Our paper on nurturing a #PositiveResearchCulture within your #research #team published by @wellcometrust.bsky.social gives useful tips for your lab. As well as making you a good team leader, nurturing culture pays off in building your science: 1/11

wellcomeopenresearch.org/articles/9-3...

scRepertoire 2: Enhanced and Efficient Toolkit for Single-Cell Immune Profiling
www.biorxiv.org/content/10.1...

@cellcellpress.bsky.social resource:
Global organelle profiling reveals subcellular localization and remodeling at proteome scale
www.cell.com/cell/fulltex...
@marcoyannic.bsky.social

Counter argument. Part of communicating science is to be engaging and interesting. An aspect of that is to be aesthetically pleasing.

Oh no, I wasn’t aware of this event. Would have loved to meet you and discuss things. Maybe I catch you next time you’re near Bonn.

🧬

Welcome to Bonn. How long are you here for?

Timescales in Cell Biology

Tissue determinants of the human T cell receptor repertoire 98% of T cells reside in tissues, yet nearly all human T cell analyses are performed from peripheral blood. We single-cell sequenced 5.7 million T cells from ten donors’ autologous blood and tonsils a...

Here is out first attempt to understand #TCR #repertoire in human tissues -Tissue determinants of the human T cell receptor repertoire Around 6 million T cells profiled at #single #cell #level www.biorxiv.org/content/10.1...

Cancer escapes immunotherapies by mutating its surface, meaning even groundbreaking #CARTCell therapies fail too often. But what if #GenerativeAI could design CAR-T with de novo binders faster, targeting resistant tumors? 🧵 www.biorxiv.org/content/10.1... (1)

Hi Jon, thanks for creating these. If there is space still please add me. :) thanks

How do T cells reach melanoma brain tumors?

Using in vivo microscopy 🔬🐭, we discovered a new route for T cells to enter the brain via distinct peri-tumoral venous vessels.

We recently published this work in Immunity: authors.elsevier.com/sd/article/S...

Graphical abstract of the paper.

How long does an mRNA stay in the nucleus? How long does it stay in the cytoplasm? In an amazing collaboration with @landthalerm.bsky.social, we used metabolic labeling, cell fractionation and mathematical modeling to quantify mRNA flow through the cell. Finally out in MSB: doi.org/10.1038/s443...

The peptide selectivity model: Interpreting NK cell KIR-HLA-I binding interactions and their associations to human diseases Combinations of the highly polymorphic KIR and HLA-I genes are associated with numerous human diseases. Interpreting these associations requires a molecular understanding of the multiple killer-cell i...

Here Malcolm Sim and Eric Long discuss peptide sensitivity of the HLA/KIR interaction. For anyone interested in this evolving subject (i.e. immune mediated disease), this review explains the difficult concepts really nicely and introduces a couple of models. #immunology
www.cell.com/trends/immun...

Please include me if not already part of one of these starter packs. :)

Happy to transition to this platform to discuss science and share our fascination.

The movie below shows a dendritic cell, highlighting the remarkable ability of immune cells to navigate their cell body and to organise their intracellular cargo (nucleus in cyan).

(Kroll et al, EMBO J 2023)

Awesome video. It looks like the left hand side projection nearly completely detaches. Is this something that ever happens. Cell extends itself too much and loses a portion of itself.

Thanks for making this starter pack. Could you include me as well.

1/ 🧬 Single-cell genomics reveals biological variations beyond cell types. Unveiling these in separate latent dim’s is known as disentanglement. Led by @AmirAliMoinfar, we develop DRVI to learn nonlinear, disentangled & interpretable latent spaces.
biorxiv.org/content/10.1101/2024.11.06.622266v1

How do organelles fit together inside a crowded cell? Answering this question requires a way to image many organelles in a whole cell at high resolution with high throughput. Our new preprint shows how to do this in yeast using soft x-ray tomography
www.biorxiv.org/content/10.1...

Nice work, we have a project looking at CD4+CD8+T-cells in tumors. Do you think CD4 expression could be induced in vivo as a mechanism to restrict the cross-reactivity? Did you ever try induce CD4 without KO CD8?