Dillon Corvino

Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.

Want to get a tough sample, like lung, looking like this? Read more!

www.biorxiv.org/content/10.1...

Domesticated animals have pulled our heavy carts and turned our large mills for centuries. But what about the opposite end of the spectrum—what if the wheel you want to turn is so small you can’t see it?

Turns out we can harness the power of bacteria to power the world’s smallest machines.

1/7 ⚛️🧪

A protein kinase D-Ikaros pathway linking invariant TCR to PLZF during iNKT cell development @jem.org @uosaka.bsky.social rupress.org/jem/article-...

The lab is looking for two PhD students.

Apply to join the team and do some exciting Immunology research.

Open Post-doc position in the lab.

Apply to join the team and do some exciting Immunology research.

A number of open positions in the lab.

Apply to join the team and do some exciting Immunology research.

The Junior PI call @ccii-kyoto.bsky.social is open until the end of the month.
Join us in Kyoto! 👇
#Immunology #Immunotherapy #Immunosky

Can’t access the paper as it’s behind a paywall. But isn’t much of this already described already. Or is the idea that these progenitors seed tissues and locally expand the novel insight?

Migrating immune cells globally coordinate protrusive forces @natimmunol.nature.com
www.nature.com/articles/s41...

NKG7 is a Stable Marker of Cytotoxicity Across Immune Contexts and Within the Tumor Microenvironment Cytotoxicity-associated genes exhibit heterogeneity at the cellular and tissue levels (left). NKG7 gene expression is strongly associated with a cytotoxic gene signature (middle). NKG7 expression is ...

🚨 New Paper in European Journal of Immunology!
We show that NKG7 is a robust marker of cytotoxicity, outperforming GZMB and PRF1 across immune cell types and tissues!
Thanks to all co-authors, @nsssusanna.bsky.social, @M.Hoelzel & @eomesodermin.bsky.social
📖 onlinelibrary.wiley.com/doi/10.1002/...

This would be a fantastic opportunity. What is the best way to contact you?

NKG7 is a stable marker of cytotoxicity across immune contexts and within the tumor microenvironment
www.biorxiv.org/content/10.1...
@eomesodermin.bsky.social @nsssusanna.bsky.social @rturiello.bsky.social

🚨 Job alert 🚨
1 PhD + 1 Technician
Our lab is looking for motivated candidates interested in understanding the impact of diets and lifestyle on tumor development, anti-tumor immunity and metastasis! Apply and join our team!
Info below 👇

🚨Open positions! The group of Laura Surace from the University Hospital Bonn is looking for a

🧑‍🔬 PhD student in metabolic regulation of tissue-resident immune cells during metastasis

🧑‍🔬 and a Technical Assistant

Application Deadline is March 31!

#job #science #PhD #immunology #openposition

icCITE-seq (intracellular cellular indexing of transcriptomes and epitopes), a scalable method that simultaneously measures surface and intracellular protein levels alongside gene expression across thousands of cells
doi.org/10.1101/2025...

Our paper on nurturing a #PositiveResearchCulture within your #research #team published by @wellcometrust.bsky.social gives useful tips for your lab. As well as making you a good team leader, nurturing culture pays off in building your science: 1/11

wellcomeopenresearch.org/articles/9-3...

scRepertoire 2: Enhanced and Efficient Toolkit for Single-Cell Immune Profiling
www.biorxiv.org/content/10.1...

@cellcellpress.bsky.social resource:
Global organelle profiling reveals subcellular localization and remodeling at proteome scale
www.cell.com/cell/fulltex...
@marcoyannic.bsky.social

Counter argument. Part of communicating science is to be engaging and interesting. An aspect of that is to be aesthetically pleasing.

Oh no, I wasn’t aware of this event. Would have loved to meet you and discuss things. Maybe I catch you next time you’re near Bonn.

🧬

Welcome to Bonn. How long are you here for?

Timescales in Cell Biology

Tissue determinants of the human T cell receptor repertoire 98% of T cells reside in tissues, yet nearly all human T cell analyses are performed from peripheral blood. We single-cell sequenced 5.7 million T cells from ten donors’ autologous blood and tonsils a...

Here is out first attempt to understand #TCR #repertoire in human tissues -Tissue determinants of the human T cell receptor repertoire Around 6 million T cells profiled at #single #cell #level www.biorxiv.org/content/10.1...

Cancer escapes immunotherapies by mutating its surface, meaning even groundbreaking #CARTCell therapies fail too often. But what if #GenerativeAI could design CAR-T with de novo binders faster, targeting resistant tumors? 🧵 www.biorxiv.org/content/10.1... (1)

Hi Jon, thanks for creating these. If there is space still please add me. :) thanks

How do T cells reach melanoma brain tumors?

Using in vivo microscopy 🔬🐭, we discovered a new route for T cells to enter the brain via distinct peri-tumoral venous vessels.

We recently published this work in Immunity: authors.elsevier.com/sd/article/S...

Graphical abstract of the paper.

How long does an mRNA stay in the nucleus? How long does it stay in the cytoplasm? In an amazing collaboration with @landthalerm.bsky.social, we used metabolic labeling, cell fractionation and mathematical modeling to quantify mRNA flow through the cell. Finally out in MSB: doi.org/10.1038/s443...

The peptide selectivity model: Interpreting NK cell KIR-HLA-I binding interactions and their associations to human diseases Combinations of the highly polymorphic KIR and HLA-I genes are associated with numerous human diseases. Interpreting these associations requires a molecular understanding of the multiple killer-cell i...

Here Malcolm Sim and Eric Long discuss peptide sensitivity of the HLA/KIR interaction. For anyone interested in this evolving subject (i.e. immune mediated disease), this review explains the difficult concepts really nicely and introduces a couple of models. #immunology
www.cell.com/trends/immun...

Please include me if not already part of one of these starter packs. :)