Results so stunningly clear they inspired this classic xkcd (xkcd.com/2400/):

Delighted to be involved, @soleimanpourlab.bsky.social !

Pancreatic α-cells are functionally heterogeneous and sex-dependently regulated by neighboring endocrine cells Glucose and paracrine regulation on α-cells, particularly with respect to sex differences, remains unclear. Hence, we imaged islets of GluCre:GCaMP6f^fl/fl mice in pancreatic slices, additionally loaded with a red Ca2+ dye, to precisely interrogate Ca2+ dynamics in α-cells and the adjacent β- and δ-cells. During a glucose ramp (1.8-10.8mM), α-cell Ca2+ oscillations were heterogeneous, antiphasic to β-cells, and inversely correlated with δ-cells. Selective inhibition of insulin receptor (InsR) and somatostatin receptor subtypes-2 and 3 (SSTR2/3) shifted the majority of α-cells to hyperactivity, delayed the decline of α-cell activity and onset of synchronized β-cell Ca2+ oscillations during the ramp. While female α-cells exhibited greater sensitivity to SSTR2/3 inhibition, male α-cells were more responsive to InsR blockade. Under complete SSTR2/3 and InsR antagonism, α-cells exhibited elevated Ca2+ oscillations but remained glucose-dependent. We conclude that intra-islet coordination fine-tunes α-cell glucose responses, with sex-specific paracrine signaling potentially shaping glucagon profiles in metabolic disease. ### Competing Interest Statement The authors have declared no competing interest.

Our new report with #YaChiHuang and #MarjanRupnik deploys high-speed multicellular imaging in pancreatic slices to reveal roles for both cell intrinsic and paracrine mechanisms in glucose inhibition of alpha cells - and the effects are sex-specific. #CRCHUM. www.biorxiv.org/content/10.1...

Delighted to be on the list of Fellows elected to the Academy of Medical Sciences today. Looking forward to playing a role in the Academy’s activities and in forging and reinforcing international partnerships.

New preprint in collaboration with my good friends from Paris, Chloe Amouyal, Herve Le Stunff and Christophe Magnan, and Xian-Cheng Jiang in New York, demonstrating the importance of de novo sphingolipid biosynthesis for normal beta cell function and mass www.biorxiv.org/cgi/content/...

NIDDK at 75 Years of Age: Great Triumphs but Concerns for Its Longevity Steven E. Kahn, Cheryl A.M. Anderson, John B. Buse, Elizabeth Selvin, David A. D’Alessio; NIDDK at 75 Years of Age: Great Triumphs but Concerns for Its Lon

"Just some of the triumphs that have come from our robust biomedical research enterprise. NIDDK, as a reflection of work done across the entire NIH, is a prime example of government monies well spent" The 75th anniversary of #NIDDK #NIH diabetesjournals.org/care/article...

Agree. This is to misunderstand how most labs use archives: as a heads-up for manuscripts already or soon to be subject to peer review.

An authoritative analysis from an islet metabolist with an (almost) 50 year perspective. Critical insights include questioning the use of succinate when testing the ADP privation model. Thanks for posting!

“Stimulus–Secretion Coupling Mechanisms of Glucose-Induced Insulin Secretion: Biochemical Discrepancies Among the Canonical, ADP Privation, and GABA-Shunt Models”

https://www.mdpi.com/1422-0067/26/7/2947

Priscila from the @guyrutter1.bsky.social lab kicking off day 2 of the Islet Club meeting at the @crchum.bsky.social

Here we report that individual leader and hub beta cells are stable in vivo, regulated by glycemic status and acutely by GLP-1RA. #LuisDelgadillo www.biorxiv.org/content/10.1...

General 1 — Boston Ithaca Islet Club / BIIC

Looking forward to welcoming colleagues and friends to the Boston-Ithaca Islet Club meeting hosted this year at the CRCHUM in Montreal, 5,6 April. There's still time to register (closing April 4 th)! www.bostonithacaisletclub.com/32nd-meeting-1.

#TobRegSky #PedSky #MedSky #EpiSky #addictionsci #policysky #polisky #neuroskyence #neurosci #PainResearch #addictionsci 🧪🛟 🫁

New NIH funding cut in half since beginning of 2025.

A new output from our lab in Montreal around the role of ER calcium stores in ensuring beta cells remain connected: #LuisDelgadillo #KarenDakessian

www.biorxiv.org/content/10.1...

Collaborations with my Canadian friends and colleagues have been among the most beneficial in my career. So important to our patients to keep them going! Thank you @bcellorg.bsky.social, @guyrutter1.bsky.social, @jimjohnsonsci.bsky.social and many many others! 🇺🇸🤝🇨🇦

Also, true story

Islet Networks Regulating Insulin Secretion - A Debate Podcast Episode · Diabetes Insights - Breakthroughs and Innovators · 2025-02-21 · 10m

podcasts.apple.com/ca/podcast/d...

Mark Huising and I debate the importance for insulin secretion of paracrine interactions within the islet versus the intrinsic heterogeneity of the beta cell population @crchum.bsky.social

Pour souligner la Journée internationale des femmes et des filles de science, notre comité ÉDI vous invite à découvrir les parcours uniques de quatre femmes.

Pour vous inscrire c’est par ici ➡️ bit.ly/4jgbnka

Le grand public est invité à participer en ligne par le biais de la plateforme Zoom.

Very pleased to share our latest report on a new lncRNA with a role in beta cell identity and function. www.sciencedirect.com/science/arti...

"The new arrangement represents one more step toward cooperation between political and economic development." -- NY Times 11/21/1938.

Investigating the pathogenicity of the recessive HNF1A p.A251T variant in monogenic diabetes using iPSC-derived beta-like cells Monogenic diabetes, formerly called Maturity-Onset Diabetes of the Young (MODY), involves single-gene mutations, typically with dominant inheritance, and has been associated with variants in 14 genes....

First post! Our new report with #ShivanMisra and #DieterEgli on a recessive HNF1A variant as modelled in iPS beta cells. From force of nature #InesCherkaoui.
medrxiv.org/cgi/content/...

Firwt post!