Scott Bagley

Second Nobel Prize Clanking Around In Trunk Of Barry Sharpless’s Car LA JOLLA, CA—Noting that the prestigious award had been rattling around loose next to a set of jumper cables and a half-empty bottle of windshield wiper fluid for approximately three years, sources co...

inpreparation.substack.com/p/second-nob...

Oooh spicy!

Chemistry: It's cooler than you think.

After that first sentence, Taco Bell parking lot is not what I expected next

Thanks Carter - super fun project and I’m real proud of it as a new method to heterocycles

Hey after 36 years of this I’m gonna celebrate that

The team at @sarponggroup.bsky.social did an amazing job pushing the boundaries this method and teasing out selectivity and expanding the scope
From the initial hits to some really cool transformations – really exciting project that I hope is useful to folks

And here it is – Annulative Editing – aka The Monster Mash. What a super collab #PfizerChemistry & @sarponggroup.bsky.social
In 1 pot, activated pyrimidines with bis-nucleophiles like amino-pyrazoles & other small hets to deliver 6/5 hets and other useful products
#MyFirstJACS
#ChemSky #ChemChat

Unleashing the Power of Potassium 2-Ethylhexanoate as a Mild and Soluble Base for Pd-Catalyzed C–N Cross-Coupling The formation of C–N bonds by Pd-catalyzed cross-coupling is one of the most widely practiced reactions in chemical synthesis. Typical reaction conditions involve either a strong base, which limits the scope of substrates, or an insoluble, inorganic base, which complicates running reactions on a large scale. Reaction conditions for C–N couplings with a base that is both mild and soluble are needed. We report the discovery of a combination of a phosphorinane ligand (L147) and a soluble carboxylate base, potassium 2-ethylhexanoate (K-2-EH), which leads to the coupling of a wide range of base-sensitive coupling partners. To explore the enhanced substrate scope of the reaction with this base and catalyst, we evaluated the scope using representative reactants selected from published partners, using chemical descriptors and clustering to ensure their chemical diversity. These results show that the combination of this phosphorinane ligand and K-2-EH can couple primary aliphatic amines, amides, sulfonamides, and heteroaromatic nucleophiles as well as acidic secondary nitrogen nucleophiles, such as arylamines, heteroarylamines, and amides, with a range of electrophiles. A side-by-side comparison to form selected coupling products in the presence of a range of previously reported bases and ligands showed that the products that decomposed under standard reaction conditions were stable with K-2-EH as a base. Finally, models of quantitative structure–reactivity relationships, trained on ligand screening data, were developed to help reveal the structural features that engender reactivity.

Cool work here in #JACSasap from the @hartwiggroup.bsky.social and AbbVie improving C-N couplings with a lipophilic/soluble alkyl carboxylate as the base
Will be helpful for parallel applications where liquid dosing is important as well as for flow synth
#ChemSky #ChemChat

I had a preventative MRI earlier this year.
Doc wanted to see what was preventing my shoulder from working

I named my fists Shohei and Ohtani because they’re the designated hitter and they throw strikes

named my fists Sagan and Hawking. They’re gonna help you see stars #ChemChat

named my fists Hofmann and Beckmann. Are you ready for some rearrangin’ #ChemChat

named my fists Mettler and Toledo. You have 20 seconds to weigh up your options #ChemChat

UNCW's Dept of Chem and Biochem is looking for four (4!) new members this cycle including:

Asst Professor Analytical Chem
Asst Professor Physical Chem
Lecturer - Bio- and general Chem
Lecturer - General Chem

Our dept is a great place to work and Wilmington's a blast!
#ChemSky #ChemJobs
Links ⬇️

I will pronounce Polarize as pole-a-reet-zay from now on

Post your favorite "Lord of the Rings" character.
Wrong answers only.

Congrats and good luck Séb!

Introduce yourself with 5 animals you’ve seen in the wild:

Bison
Pheasant
Harbor seal
Star-nosed mole
Fisher Cat

(S)-cargot (R)-cargot

“The desired product was not identified by TLC, LC-MS or NMR. The reaction mixture was set aside for later investigation”

It’s 6 5
Or 6 6
Or even 6 10 but def not 6 7
(Could be though)

Soon Martin. Very soon

Introduce yourself with 5 concerts you've seen.

Rush
Van Halen
Metallica
The Police
BB King

I was in high school in MA at the time and the feeling was definitely not mutual …

Don’t worry they have their best people on it

A very cool chemical reaction showing 2 separate generic heterocycles fusing into one. Over the reaction arrow it says “one pot one reagent solvent heat”.

Tired of building 6/5 heterocycles?

Try the Monster Mash!
(It’s a Heterocycle Smash!)
[Wrong holiday, sorry]

Het fusion coming soon to a #JACSasap near you
#ChemSky #ChemChat