A small contribution from us & Edi Gerhardt @febsj.bsky.social
Highlighting the recent findings: Structure of the NifL-NifA complex controlling nitrogen fixation gene expression in Azotobacter
febs.onlinelibrary.wiley.com/doi/10.1111/...
@sfb1381.bsky.social @hhu.de @mibinet.bsky.social
The molecular basis of how expression of nitrogen fixation genes is regulated was not fully understood. Here, we define how NifL and NifA interact and now have a blueprint for engineering microbes that could supply nitrogen to crops, reducing our dependence on chemical fertilisers.
Thrilled to share the peer-reviewed version of our NifL-NifA structure paper: febs.onlinelibrary.wiley.com/doi/10.1111/....
I am greatful to @ukri.org for the funding, the @johninnescentre.bsky.social for the support over the years and all co-authors who joined me in this challenge.
In this study, we have combined cryo-EM with extensive biochemical and genetic characterization of the interaction surface to shed light on the molecular basis of the anti-activation of the NifA protein, the master regulator of nitrogen fixation genes.
I am incredibly proud to share with you all my latest preprint on the structure of the NifL-NifA complex: doi.org/10.1101/2025...
Thanks to all my mentors and collaborators at the @johninnescentre.bsky.social and BBSRC for the funding.
