JB Manent

🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...

Fantastic work! And the new crispr strategy looks very powerful!

I am thrilled to share our latest story led by the incredibly talented Brooke D’Arcy and Camila Musso. We discover a rich world of local gene expression in radial glia, essential neural and glial precursors, and develop a new method for sub-cellular mRNA manipulation. www.biorxiv.org/content/10.1...

Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou

🚨 Excited to share the latest preprint form the lab ➡️https://tinyurl.com/32d3be9f

Here we tackle a long-standing chicken-or-egg 🐣🥚question in #autism and developmental neuroscience

➡️ Is excitation–inhibition (E:I) imbalance a "cause" or a "consequence" of #autism?

Check out what we found!
🧵1/n

Now out in @natneuro.nature.com

What happens to the brain’s body map when a body-part is removed?

Scanning patients before and up to 5 yrs after arm amputation, we discovered the brain’s body map is strikingly preserved despite amputation

www.nature.com/articles/s41593-025-02037-7

🧵1/18

Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...

🎓 My team is seeking a PhD student in Biochemistry & Cell Biology at I2BC, Paris-Saclay!
🔬 Study cytoskeletal signaling in collective cell migration
🌍 Fully funded, 3 yrs | 📍 Gif-sur-Yvette, France
🗓️ Apply by Aug 22 via the following link:
emploi.cnrs.fr/Offres/Docto...

Interested in cortical malformations 🧠 and #epilepsy?
We will soon have 2 open positions:
- early career postdoc with experience in slice & in vivo electrophysiology
- research engineer with experience in bioinformatics and data analysis
Please get in touch (DM) if interested.
Please repost!

An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus - Nature Neuroscience The topographical organization of cells in the hippocampus reflects its ability to regulate mood and cognition. Here the authors generate a spatially resolved gene expression map in the human hippocam...

Excited to share this huge team effort collaboration supervised by Stephanie Page in Translational Neuroscience @lieberinstitute.bsky.social and @stephaniehicks.bsky.social @jhubiostat.bsky.social to generate a spatio-molecular resource of the hippocampus in human 🧠

www.nature.com/articles/s41...

🧠 Opportunity for a post-doctoral position on human neurobiology, funded by the @erc.europa.eu!
🧫You want to use human pluripotent stem cell based models to understand the evolution of human cerebellar neurons and disorders, this position is for you!
🔗Apply here: emploi.cnrs.fr/Offres/CDD/U...

Visuel graphique officiel de la Plateforme d’Expertise Maladies Rares de l’AP-HM, sur fond bleu avec un double hélice d’ADN en lumière bleue et le texte « Actualité – Plateforme d’expertise Maladies Rares » accompagné du logo des Hôpitaux Universitaires de Marseille.

Vue de la salle de conférence lors de la Première Journée de Neurosciences Translationnelles sur l’Épilepsie à Marseille, montrant un intervenant présentant un diaporama face à un public d’environ 70 participants assis.

Portrait de groupe de quatre intervenants de la Première Journée de Neurosciences Translationnelles sur l’Épilepsie à Marseille : de gauche à droite, Eya Bourguiba, Audrey Clément, Professeur Fabrice Bartolomei et Professeur Mathieu Milh, souriants et debout devant la salle de conférence.

Première Journée de Neurosciences Translationnelles sur l’Épilepsie à Marseille 🧠
Cliniciens, chercheurs et ingénieurs réunis pour échanger sur la génétique, les biomarqueurs et les nouvelles approches thérapeutiques.
📄 Lire l’article complet : fr.ap-hm.fr/site/maladie...

#JNeurosci: @srirams433.bsky.social‬ Guzman-Clavel et al. uncover roles for Mef2c in cortical development: regulation of laminar subtype specification during embryogenesis & axon targeting in postnatal callosal neurons. @oneneuroinitiative.bsky.social
https://doi.org/10.1523/JNEUROSCI.0201-25.2025

Brain Surfaces of 70 primate species

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To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!

🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...

Our new preprint is out 🤩!
Proud to share our work uncovering the molecular diversity and developmental origins of cerebellar astrocytes. A deep dive into cerebellar gliogenesis using scRna-seq and lineage-tracing approaches. Big thanks @Valentina_Cerr @BuffoLab giacomo Turrini.

🔬 New preprint out!

Thrilled to share our new preprint, where we uncover the molecular diversity and developmental origins of cerebellar astrocytes using multi-omic approaches.

📄 www.biorxiv.org/content/10.1...

#scRNAseq #astrocytes #neuroscience #glia #cerebellum @biorxiv-neursci.bsky.social

MOTL: enhancing multi-omics matrix factorization with transfer learning - Genome Biology Joint matrix factorization is popular for extracting lower dimensional representations of multi-omics data but loses effectiveness with limited samples. Addressing this limitation, we introduce MOTL (...

Excited to share David Hirst's PhD work!
🧬 When you only have a few datasets available for multi-omics integration, for instance because you work on rare diseases, one solution is Transfer Learning. Introducing #MOTL - now available in Genome Biology!

doi.org/10.1186/s130...

Precision Functional Mapping of the Individual Human Brain Near Birth Cortical areas are a fundamental organizational property of the brain, but their development in humans is not well understood. Key unanswered questions include whether cortical areas are fully establi...

Newborn brains already show individual patterns of functional organization. 🧠✨

Using #fMRI for precision mapping, researchers at @washumedicine.bsky.social found that each baby's brain has a unique layout—already present just after birth.

www.biorxiv.org/content/10.1...

#neuroskyence #MRI 🧪

Complex genetic variation in nearly complete human genomes - Nature Using sequencing and haplotype-resolved assembly of 65 diverse human genomes, complex regions including the major histocompatibility complex and centromeres are analysed.

Two papers in today's issue of @nature.com ‬: 1) we assemble 65 genomes to near completion, including centromeres and the MHC. tinyurl.com/3huhax6w. 2) we sequence 1,019 genomes from the 1kGP with long reads, revealing SVs down to low allele frequencies tinyurl.com/wbx3we9x.

Marsupial single-cell transcriptomics identifies temporal diversity in mammalian developmental programs Menchero et al. generate a single-cell transcriptomic atlas in the opossum and show rapid progression of transcriptional programs in specific tissues relative to morphological landmarks. This shift in...

Thrilled to share that our latest work on marsupial heterochrony is now online at @cp-devcell.bsky.social @cellpress.bsky.social @lab-turner.bsky.social @crick.ac.uk We used scRNAseq to understand the asynchronous progression of developmental programmes in marsupials www.cell.com/developmenta...

Hey, it's out!
doi.org/10.1016/j.ce... Aligning Big Brains and Atlases, ABBA in short, is published in Cell Reports @cp-cellreports.bsky.social . @biancasilvalab.bsky.social's lab added an analysis pipeline on top of it (BraiAn) and did all the relevant biological work. What is it ? Short thread:

ER_2025 #endoplasmicreticulum #ER #conference Paris October 8-10 2025 Register! itbcrde.inserm.fr/index.php?page…

Neural models for detection and classification of brain states and transitions - Communications Biology A deep learning self-supervised hybrid CNN-autoencoder model is used to detect brain states and transitions, like wakefulness, slow oscillations and microarousals, during the emergence from anesthesia...

Neural models for detection and classification of brain states and transitions
www.nature.com/articles/s42...
#neuroscience

Barcoded Rabies In Situ Connectomics for high-throughput reconstruction of neural circuits Sequencing of oligonucleotide barcodes holds promise as a high-throughput approach for reconstructing synaptic connectivity at scale. Rabies viruses can act as a vehicle for barcode transmission, than...

1/ Mapping synaptic connectivity between individual neurons is extremely laborious. We developed BRISC, a new method that makes it possible to map inputs onto 100s of neurons in the same animal in a matter of weeks! Led by Alex Becalick and @antblot.bsky.social. 🧵

www.biorxiv.org/content/10.1...

Ivan's Seizure Helpers: A Bilingual (ES/EN) Children's Book Based on personal experience, this book introduces seizure awareness and basic first aid to elementary-aged children.

Dear @jbmanent.bsky.social, our son has had 5 seizures. He's stopped breathing, his lips turning blue. We were terrified. We turned that fear into a book to help raise awareness — Ivan’s Seizure Helpers. It’s now a Kickstarter 💜 Please support and help amplify! kickstarter.com/projects/iva...

YouTube video by AP-HM - Hôpitaux Universitaires de Marseille Jérémi, infirmier en psychiatrie à la Conception - Un métier authentique, une équipe solide

On a besoin d’un petit coup de main 💬
On recrute des infirmier·ères en psychiatrie pour nos équipes à l’Hôpital de la Conception, à Marseille.
Un partage, un relais, un mot : ça peut vraiment aider.
Merci à celles et ceux qui feront passer le message 💙

Please join the Next GDR Organoids webinar this Friday!!! June 27th from 1:00 PM to 2:00 PM (CET).
Dr Michael L. Shuler, Professor Emeritus @cornelluniversity.bsky.social will present his work on Body-on-a-Chip zoom : univ-lille-fr.zoom.us/j/9841896627... @cnrs.fr @inserm.fr

🎥 REPLAY DISPONIBLE – Symposium franco-belge « Les mille premiers jours de la vie » du 18 juin 2025

Retrouverez le replay de cette journée d’échanges scientifiques ici : autisme-neurodev.org/evenements/2...

Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data Building a mechanistic understanding of cell fate decisions remains a fundamental goal of developmental biology, with implications for stem cell therapies, regenerative medicine and understanding dise...

Our latest "Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data"

A rigorous mathematical foundation for Waddington's landscape to study cell fate decision making

Applied to ventral neural tube development

www.biorxiv.org/content/10.1...

Yay! Congrats!