Mark Brandon

How good is your place cell model?

Come benchmark yours against real data - nearly 70K CA1 rate maps in various geometric shapes across weeks - collected and curated in my lab by the great @jquinnlee.bsky.social and @atkeinath.bsky.social

09.04.2025 00:06 — 👍 4    🔁 1    💬 0    📌 0

Mouse CA1 Calcium Imaging and Behavioural Dataset in 3x3 Geometric Morph Paradigm The following dataset was collected by Dr. J. Quinn Lee, Dr. Alexandra T. Keinath, and Erica Cianfarano in the laboratory of Dr. Mark P. Brandon. All methods and details are described in the original ...

The dataset and code for our recent paper in Neuron (tinyurl.com/yc48d6vr) is online now!
The data is available on Zenodo (zenodo.org/records/1486...) and code on Github (github.com/jquinnlee/ge...). Big thanks to @markbrandonlab.bsky.social and @atkeinath.bsky.social on this effort! #neuroskyence 🧠

08.04.2025 21:45 — 👍 10    🔁 3    💬 0    📌 1

Stuart, Mark, Gilberto, and me!

Congrats Dr Gilberto R Vite! 🎉🍾

Gilberto successfully defended his PhD, on the role of the thalamus in coordinating activity in the entorhinal cortex.

Big thanks to his committee, Laura Colgin, @markbrandonlab.bsky.social, Stuart Trenholm, and @sylvainbaillet.bsky.social 🙏🙏

07.04.2025 15:59 — 👍 17    🔁 1    💬 0    📌 1

Grateful to @apnews.com for covering our recent @pnas.org article on how London taxi drivers plan routes:

apnews.com/video/how-th...

#neuroskyence

12.02.2025 15:48 — 👍 33    🔁 4    💬 0    📌 0

Screenshot of article entitled "Distinct changes to hippocampal and medial entorhinal circuits emerge across the progression of cognitive deficits in epilepsy" by Yu Feng, Keziah S. Diego, Zhe Dong, ..., Nadia N. Khan, Denise J. Cai, and Tristan Shuman. In brief: Feng et al. demonstrate that memory deficits in temporal lobe epilepsy involve multiple discrete mechanisms with distinct time courses. In epileptic mice, early-onset memory deficits are associated with disrupted hippocampal synchronization, while more severe, lateonset impairments are associated with disrupted synchrony of medial entorhinal cortex circuits.

New paper out in Cell Reports! Led by @susieyufeng.bsky.social, we found that chronic epilepsy in mice drives distinct synchronization deficits in hippocampus and MEC, with early changes in HPC and late-onset changes in MEC that align with progressive memory impairment.
www.cell.com/cell-reports...

28.01.2025 20:17 — 👍 52    🔁 21    💬 1    📌 1

Here is the MIT Tech Review article covering the data collection linked to this new Phd Opportunity at our new International Centre for NeuroArchitecture and NeuroDesign:

www.technologyreview.com/2024/09/13/1...

10.01.2025 10:59 — 👍 32    🔁 12    💬 0    📌 0

What are the brain’s “real” tuning curves?

Our new preprint "SIMPL: Scalable and hassle-free optimisation of neural representations from behaviour” argues that existing techniques for latent variable discovery are lacking.

We suggest a much simpl-er way to do things.
1/21🧵

25.11.2024 13:39 — 👍 70    🔁 22    💬 3    📌 3

Now out in Neuron! We benchmark place cell models using a massive CA1 dataset—nearly 70,000 rate maps—collected as mice explore environments with different geometries

BVC models perform remarkably well, but we hope this dataset/approach becomes a resource for testing/refining place cell models

22.11.2024 19:26 — 👍 23    🔁 10    💬 1    📌 0