Here, we develop a #CRISPR #epi-editing platform to probe #GeneRegulation in the brain. Silencing Neurexin-1 promoters in neurons affects downstream promoters & splicing patterns. Our data reveals transcriptional interference as key to shaping cell type-specific RNA isoforms of synaptic genes. 🧪
16.09.2025 14:15 — 👍 5 🔁 0 💬 0 📌 0
The Gomez LAB
Hi Monica, may I be added to the feed? My neurobiology lab is at UC Berkeley an my lab website: www.andreagomezlab.com
15.09.2025 20:31 — 👍 1 🔁 0 💬 1 📌 0
mRNA 3′UTRs chaperone intrinsically disordered regions to control protein activity
More than 2,700 human mRNA 3′UTRs have hundreds of highly conserved (HC) nucleotides, but their biological roles are unclear. Here, we show that mRNAs with HC 3′UTRs mostly encode proteins with long intrinsically disordered regions (IDRs), including MYC, UTX, and JMJD3. These proteins are only fully active when translated from mRNA templates that include their 3′UTRs, raising the possibility of functional interactions between 3′UTRs and IDRs. Rather than affecting protein abundance or localization, we find that HC 3′UTRs control transcriptional or histone demethylase activity through co-translationally determined protein oligomerization states that are kinetically stable. 3′UTR-dependent changes in protein folding require mRNA-IDR interactions, suggesting that mRNAs act as IDR chaperones. These mRNAs are multivalent, a biophysical RNA feature that enables their translation in network-like condensates, which provide favorable folding environments for proteins with long IDRs. These data indicate that the coding sequence is insufficient for the biogenesis of biologically active conformations of IDR-containing proteins and that RNA can catalyze protein folding. ### Competing Interest Statement The authors have declared no competing interest. Pershing Square Foundation, https://ror.org/04tce9s05 G. Harold & Leila Y. Mathers Foundation National Institutes of Health, DP1GM123454, R35GM144046 Memorial Sloan Kettering Cancer Center, https://ror.org/02yrq0923, P30 CA008748
Very interesting looking work from @christinemayr.bsky.social lab
I'll put it at the top of my reading list, but the abstract already gave me some cool ideas.
#RNASky #RNABiology 🧪
www.biorxiv.org/content/10.1...
07.07.2025 21:23 — 👍 9 🔁 2 💬 0 📌 0
In this time of chaos - something good! We are excited to share our final (or near final) speaker list for the 3rd UCSF Full Circle Symposium 4/3-4/4 to highlight Native biologists! Please share the word and register to attend the webinar in person! More info: qbi.ucsf.edu/full-circle-...
05.03.2025 20:59 — 👍 32 🔁 14 💬 2 📌 1
Yesss! #RNAsky
26.02.2025 17:33 — 👍 13 🔁 3 💬 0 📌 1
Our latest study is available as a preprint.
We show that psychedelics induce subtle changes in gene expression but robust changes in alternative splicing lasting at least one month, suggesting that alternative splicing may represent a general mechanism for prolonged plasticity in neurons. #RNAsky
17.01.2025 05:01 — 👍 35 🔁 10 💬 0 📌 4
Thank you to @mayoonthebrain.bsky.social & @indigenerd.bsky.social for keynoting, & Tristan McClure-Begley, Katherine Bonson, Xiangmin Xu, Daniele Piomelli, Adrian Preda, and Kate Lawson, Steve Grant, & all attendees, for participating in this #psychedelic symposium @UCIrvine yesterday!
19.11.2024 20:53 — 👍 11 🔁 3 💬 3 📌 1
Stimulating discussions. Many take-aways. Thanks @svmahler.bsky.social
19.11.2024 21:54 — 👍 1 🔁 0 💬 0 📌 0
We're a feminist, anti-colonial laboratory, which means our methods foreground values of humility, accountability, and good land relations.
We’re working to do research differently.
Memorial University
https://civiclaboratory.nl/
Social media account of the ERC SyG funded project UNLEASH. We will harness the splicing code for targeted control of gene expression using small molecules!
Associate of Professors, Aficionado of Synapses, Runner of Miles, Practicer of Kindness, Tracker of Tenure, Denizen of South Philly. My thoughts are mine. He/his/him. Signal: drosophilosophy.07 (you know, if you ever need to talk). www.moscalab.org
Postdoc in the Ingolia Lab @ UC Berkeley. Interested in the crosstalk between neuronal activity and gene expression. 김정우.
(Psychedelic) neurophysiology researcher (postdoc) at University of Michigan (https://www.omarlab.org)
Assistant Professor | Neuroscientist trained as a developmental neuroscientist + in vivo electrophysiologist | Sex, stress, development, dopamine, reward, motherhood | NYU PhD/ Pitt PD/ UTD PI
Evolution, Development and Aging of the Nervous System
August 2-7, 2026
Salve Regina University, Newport RI USA
https://www.grc.org/neural-development-conference/2026/
Chair: Bassem Hassan, PhD
Vice-Chairs: Corey Harwell, PhD and Julie Siegenthaler, PhD
Professor at Cornell BME. Studying the neurobiology of psychiatric #drugs including #ketamine and #psychedelics.
https://alexkwanlab.org
Past, Present and Future of Life
Here and Elsewhere
PI: Betül Kaçar
Account managed by lab members.
✨
kacarlab.org
The Marqusee Lab @UCBerkeley uses #biophysics to study #proteinfolding in basic and cellular contexts. Account is student/postdoc run. All posts in kcal/mol.
molecular systems biology of the synapse | snsf ambizione | spatial proteomics | molecular neuroscience
https://bit.ly/MvO
Assistant Professor of Molecular Biology, Center for Alzheimer's and Neurodegenerative Diseases, UT Southwestern. My lab studies damaged things. Sometimes we fix them. Hiring! Write if interested in postdoc or tech position. https://www.davidwsanders.com
My lab at SickKids in Toronto, Canada, studies brain development. We want to know how nerve cells wire to form complex neural circuits. Here for science, actions to make our world a peaceful, safe, and healthy place, laughs, and cycling.
D. M. David-Chavez, PhD | Indigenous Scientist | Caribbeana Mama | Indigenous Land & Data Stewards Lab Director | Asst. Prof @ Land Grant Uni | Data Warrior | Listening with the ancient ones...
Indigenouslandstewards.org
Drosophila Neuroscientist | Assistant professor at UC Berkeley in Neuroscience and MCB (@berkeleymcb.bsky.social)
https://www.fisherlab.science/
Assistant Professor at @UCSF_BTS | @HHMINEWS HGF | | Loving membrane proteins every day https://www.wcoyotelab.com
Assistant Professor in the UC Berkeley Department of Molecular and Cell Biology, mtDNA obsessed, mother to the Lord of Chaos, she/her, personal account, views do not reflect those of my employer.
https://www.samlewis-phd.com/
neuroscientist studying vision at Univ of Oregon
nielllab.uoregon.edu
