Andrea Gomez (@indigenerd) — Bluesky Profile

3 months ago

We used rabies virus 👾 to map how #psilocybin modifies long-range circuits 🧠, revealing network-specific reorganization that we didn’t expect.

The full study is now online at Cell. @cp-cell.bsky.social

Paper 👉 www.cell.com/cell/fulltex...

Thread for a synopsis 👉
bsky.app/profile/alex...

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6 months ago

Novel environment exposure drives temporally defined and region-specific chromatin accessibility and gene expression changes in the hippocampus - Nature Communications Hippocampal neurons adapt to experience through changes in gene expression and chromatin accessibility. Here, authors show that novel environment exposure induces region- and cell-type specific transc...

Extremely excited to share the outcome of a fantastic collaboration with @erinduffyphd.bsky.social revealing how experiences reshape hippocamapl chromatin and gene expression.
Check out our searchable gene database and look up your favorite gene 🧬

www.nature.com/articles/s41...

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5 months ago

Here, we develop a #CRISPR #epi-editing platform to probe #GeneRegulation in the brain. Silencing Neurexin-1 promoters in neurons affects downstream promoters & splicing patterns. Our data reveals transcriptional interference as key to shaping cell type-specific RNA isoforms of synaptic genes. 🧪

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5 months ago

The Gomez LAB

Hi Monica, may I be added to the feed? My neurobiology lab is at UC Berkeley an my lab website: www.andreagomezlab.com

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8 months ago

mRNA 3′UTRs chaperone intrinsically disordered regions to control protein activity More than 2,700 human mRNA 3′UTRs have hundreds of highly conserved (HC) nucleotides, but their biological roles are unclear. Here, we show that mRNAs with HC 3′UTRs mostly encode proteins with long intrinsically disordered regions (IDRs), including MYC, UTX, and JMJD3. These proteins are only fully active when translated from mRNA templates that include their 3′UTRs, raising the possibility of functional interactions between 3′UTRs and IDRs. Rather than affecting protein abundance or localization, we find that HC 3′UTRs control transcriptional or histone demethylase activity through co-translationally determined protein oligomerization states that are kinetically stable. 3′UTR-dependent changes in protein folding require mRNA-IDR interactions, suggesting that mRNAs act as IDR chaperones. These mRNAs are multivalent, a biophysical RNA feature that enables their translation in network-like condensates, which provide favorable folding environments for proteins with long IDRs. These data indicate that the coding sequence is insufficient for the biogenesis of biologically active conformations of IDR-containing proteins and that RNA can catalyze protein folding. ### Competing Interest Statement The authors have declared no competing interest. Pershing Square Foundation, https://ror.org/04tce9s05 G. Harold & Leila Y. Mathers Foundation National Institutes of Health, DP1GM123454, R35GM144046 Memorial Sloan Kettering Cancer Center, https://ror.org/02yrq0923, P30 CA008748

Very interesting looking work from @christinemayr.bsky.social lab

I'll put it at the top of my reading list, but the abstract already gave me some cool ideas.

#RNASky #RNABiology 🧪

www.biorxiv.org/content/10.1...

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1 year ago

In this time of chaos - something good! We are excited to share our final (or near final) speaker list for the 3rd UCSF Full Circle Symposium 4/3-4/4 to highlight Native biologists! Please share the word and register to attend the webinar in person! More info: qbi.ucsf.edu/full-circle-...

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1 year ago

Yesss! #RNAsky

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1 year ago

Newly discovered mechanism enables precise gene regulation by combining DNA and RNA epigenetics Our genes contain all the instructions our body needs to function, but their expression must be finely regulated to guarantee that each cell performs its role optimally. This is where DNA and RNA epig...

Newly discovered mechanism enables precise gene regulation by combining DNA and RNA epigenetics #rnasky phys.org/news/2025-01...

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1 year ago

Our latest study is available as a preprint.

We show that psychedelics induce subtle changes in gene expression but robust changes in alternative splicing lasting at least one month, suggesting that alternative splicing may represent a general mechanism for prolonged plasticity in neurons. #RNAsky

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1 year ago

Thank you to @mayoonthebrain.bsky.social & @indigenerd.bsky.social for keynoting, & Tristan McClure-Begley, Katherine Bonson, Xiangmin Xu, Daniele Piomelli, Adrian Preda, and Kate Lawson, Steve Grant, & all attendees, for participating in this #psychedelic symposium @UCIrvine yesterday!

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1 year ago

Stimulating discussions. Many take-aways. Thanks @svmahler.bsky.social

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