Michael Platten, MD

👉 We are excited to announce that the #EANO2025 Abstract Book is now available online! Download & explore it today: lnkd.in/dg79p6wM

#AbstractBook #NeuroOncology #neurosurgery #cancernurse #neuropathology #radiotherapy #AHP #btsm

This month’s cover illustration depicts distinct malignant glioma (upper left) and metastatic (bottom right) TMEs as collages of aperiodic penrose tiles overlaid on a stylized positron emission tomography (PET) scan of the brain.

The October issue of #ScienceImmunology is out!

This month's cover highlights a Review that delves into brain tumor development and examines factors contributing to the immunosuppressive brain tumor microenvironment. Learn about this and more: https://scim.ag/46HgHcl

The immunology of brain tumors The cellular and molecular determinants of the antigenicity of brain tumors and the immunosuppressive brain tumor microenvironment are reviewed.

The immunology of brain tumors | Science Immunology www.science.org/doi/10.1126/...

Happy to share this review article by @lukasbunse.bsky.social, Theresa Bunse and I @platten-lab.bsky.social, Michael Kilian, Fran Quintana @quintanalabhms.bsky.social.

🧠 Recently published in Neuro-Oncology: EANS–EANO Guidelines on the Extent of Resection in Gliomas. We’re proud to share the outcome of collaborative effort by the joint task force of EANS and EANO, providing evidence-based recommendations for clinical practice.
🔗 academic.oup.com/neuro-oncolo...

💡Only a few seats left for the EANO Tumor Board 2025, taking place on October 15 in Prague. Join us for interactive case-based discussions and expert insights. Registration is free for EANO members. Please register by October 3.
Learn more: www.eano.eu/eanomeetings...

Neuro-Oncology Pediatrics - explore the first issue

Discover Neuro-Oncology Pediatrics, a new #OA journal launched by @eanoassociation.bsky.social & @neuroonc.bsky.social with editorial leadership from EANO, SNO, & ASNO, focused on advancing care for children and young adults with CNS tumors.

See the first articles: oxford.ly/4mNN1iF

📣 New journal launch! Neuro-Oncology Pediatrics is live — an open-access journal advancing global research and care for children & young adults with brain tumors.
A joint EANO & @neuroonc.bsky.social initiative.
🔗 Read more: www.eano.eu/about/news/n...
#NeuroOncology @oxfordacademic.bsky.social

an incredibly dedicated team of clinical trialists, basic and translational researchers and immune monitoring team @dkfz.bsky.social, @dkfz-iic.bsky.social, I have the privilege to work with with the goal to develop a viable tratment for patients with this devastating disease. 5/5

@neurooncologyhd.bsky.social @neurooncotue.bsky.social, Frankfurt, Mannheim, all patients and their relatives, Roche for the in-kind contribution of atezolizumab, the fantastic research collaborators @bihatcharite.bsky.social and HI-TRON, and first and foremost 4/

in this "reverse translation" trial which was supported by the German Cancer Aid. Huge thanks to @dkfz.bsky.social as the trial sponsor, the fantastic NCT Trial Center, all participating sites from the Neurooncology Working Group @krebsgesellschaft.bsky.social 3/

A H3K27M-targeted vaccine in adults with diffuse midline glioma - Nature Medicine In this compassionate use study, treatment of adult patients with H3K27M-mutant diffuse midline glioma with a long peptide vaccine targeting H3K27M led to vaccine-induced peripheral T cell immune resp...

combined with radiotherapy and the immune checkpoint inhibitor atezolizumab. The trial was based on encouraging results in patients with recurrent diffuse midline gliomas

www.nature.com/articles/s41...

We will now follow-up our patiens, analyze the data and continue our analyses 2/

Excited to announce that we have completed accrual of the INTERCEPT-H3 trial (NCT04808245). This phase 1 first-in-human trial explores safety and immunogenicity of a long peptide vaccine targeting the clonal driver mutation H3K27M in adult patients with newly diagnosed diffuse midline gliomas 1/

📣 Have you heard? Registration for #EANO2025, taking place Oct 16-19, 2025 in #Prague (CZ) is open! Don’t miss out on this fantastic experience to meet experts in the field of #NeuroOncology. Early Bird fees available until July 31, 2025. 👉 eano.eu/eano2025/reg... #braincancer #medsky

🧠 June 8 is #WorldBrainTumorDay — raising awareness & understanding of brain tumors.
EANO supports progress in #NeuroOncology through research, education & collaboration.
🔗 Learn more: www.eano.eu
#btsm #BrainTumor #Oncology

Der Wissenschaftsrats-Vorsitzende Wolfgang Wick mit dem nebenstehenden Zitat "Wir brauchen eigenständige Wissenschaftsinfrastrukturen in Europa", das aus einem FAZ-Gastbeitrag vom 4.6.25 stammt.

Wissenschaft braucht verlässliche Infrastrukturen - viele davon liegen noch in den USA. Der WR-Vorsitzende
@wickwolfgang.bsky.social fordert in der @faznet.bsky.social eine europäische Strategie für mehr Unabhängigkeit👉 www.faz.net/aktuell/wiss...
#DigitaleSouveränität #Forschung #Infrastruktur

Join us this week on Thursday (22nd May) for our next i2 seminar! This week it’s all about T cells in cancer!

The organizing committee of the UNITE conference would like to thank all speakers for their excellent presentations and all participants for the valuable discussions. @wickwolfgang.bsky.social @michael-platten.bsky.social

🧠 Join the next #EANOYoungsters Journal Club on June 5, 16:30–17:30 CEST!
Discussing: "Rapid molecular profiling of CNS tumors" www.nature.com/articles/s41... (Patel et al., Nat Med 2025)
📍Free & open to all EANO members
🔗 www.eano.eu
#NeuroOncology #BrainTumors #JournalClub

The second day of the UNITE conference. Today there will also be a contribution from a patient on the book “Alles gut? Alles gut.” by Marlene Assmann. www.jacobystuart.de/buecher-von-...

Bottom-up synthetic immunology - Nature Nanotechnology This Perspective highlights bottom-up molecular engineering and modular nanobiotechnological approaches for developing effective immunotherapeutics and their potential in personalized medicine.

The SynthImmune project by Heidelberg University& partner institutes advances a "bottom-up" synthetic biology approach to immunotherapies.
Hoping they do well in the German government's Excellence Strategy—anticipating the announcement on 22 May.

Perspective article: www.nature.com/articles/s41...

⏱️ Clock is ticking! Final call for abstract submissions for #EANO2025 in #Prague. Don't miss this chance to share your work contribute to the advancement of #NeuroOncology. Submit now via our official event website: www.eano.eu/eano2025/ until May 6, 2025, 23.59 CEST!
@oncoalert.bsky.social

Prediction of tumor-reactive T cell receptors from scRNA-seq data for personalized T cell therapy - Nature Biotechnology Tumor-reactive T cell receptors are rapidly identified from lymphocyte scRNA-seq data.

Fantastic initiative - we could offer to provide our predicTCR and makeTCR tools to identify tumor-reactive TCRs and clone them for testing.

www.nature.com/articles/s41...

www.biorxiv.org/content/10.1...

Wir freuen uns, die UNITE-Glioblastom-Konferenz ankündigen zu können, die am 14. und 15. Mai 2025 im DKFZ-Kommunikationszentrum in Heidelberg stattfinden wird. melden Sie sich heute an: www.unite-glioblastoma.de/unite-confer...

🚀 We are proud to launch the new "Ambassadors for the ERC" initiative, together with @ercgrantees.bsky.social !

We aim to empower researchers across Europe to advocate for frontier research. Find out more 👉 bit.ly/44bQzp7

🌟 Excited to see what can be achieved!

#Amb4ERC

Photo: Jung/DKFZ

@michael-platten.bsky.social has been selected and nominated as Ambassador for the ERC network. The @erc.europa.eu & the @ercgrantees.bsky.social launched the new Ambassadors on 28 April. This joint initiative aims to promote investment in frontier research and highlight the importance of #research.

🗓️ Only one week to go! The abstract submission deadline for #EANO2025 in #Prague is approaching fast. This is your opportunity to share your findings, collaborate with peers, and be recognized in the field of #NeuroOncology. Submit your abstract now: www.eano.eu/eano2025/ #btsm

Apply to DKFZ Marie Skłodowska Curie MasterClasses

Do you want to do your #postdoc in #cancerresearch with the most prestigious #fellowship in Europe? Apply to DKFZ Marie Skłodowska Curie MasterClasses by May 19. Projects in #cellandmolecularbiology #genomics #bioinformatics #immunology #medicaltechnology, #epidemiology.
Apply here: t1p.de/nx6tu

#brain #tumors | Michael Platten This is the research team DKFZ Deutsches Krebsforschungszentrum Helmholtz-Gemeinschaft Universität Heidelberg Universitätsmedizin Mannheim Neurooncology Heidelberg Health + Life Science Alliance I hav...

www.linkedin.com/posts/michae...

Vaccine-induced T cell receptor T cell therapy targeting a glioblastoma stemness antigen - Nature Communications Vaccination in glioblastomas does lead to the emergence of tumour-antigen-specific T cells but T cell dysfunction, poor tumour infiltration and persistence hinder efficient tumour killing. Here author...

🚀 New publication! We developed a PTPRZ1-specific TCR-T cell therapy for glioblastoma.

🔬 Key findings:
✅ Identified a PTPRZ1-reactive TCR from a vaccinated patient
✅ Kills glioblastoma cells with no off-target effects
✅ Eliminates tumors in murine brain models

🔗 www.nature.com/articles/s41...

Don’t miss our i2 seminar today at 4 pm where we will hear more about immunogenic cancer editopes and the lineage tree of tissue macrophage development.
Join us for a lively discussion and snacks and drinks! 🧪
Today at 4pm in the main building 👇