Andreas Linkermann

Selective disruption of lipid peroxide homeostasis in intratumoral regulatory T cells by targeting FSP1 enhances cancer immunity Deletion of Aifm2 disrupts Treg cell immunosuppression within tumors without inciting autoimmune pathology in mice.

Thrilled to have contributed to this work led by @jgcastillo.bsky.social during his PhD at UC Berkeley w/ Michel DuPage. Targeting FSP1 in T cells boosts anti-tumor immunity by relieving Treg suppression, revealing a new immunomodulatory therapeutic axis. www.science.org/doi/10.1126/...

When heme is low, copper kills cancer Heme carries oxygen and is critical for the control of redox reactions. In this issue of Cell, Lewis and Gruber et al. demonstrate how low concentrations of heme destabilize complex IV of the respirat...

Reviewing the paper by the Kats´ lab published today in #Cell, "Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia", I learned that cuproptosis is real! Here is my preview:

When heme is low, copper kills cancer:
www.cell.com/cell/fulltex...

What does not kill you makes you Weaker! - Cell Death & Differentiation Tumor cell evasion from regulated cell death is a hallmark of cancer [1]. Davern et al. now identify resistance to mitochondrial apoptosis to represent the common mechanism by which persister cells th...

Here is a link to our most recent editorial for #CDDiff, Cell Death and Differentiation. It´s on work by Tony Letai and team.
www.nature.com/articles/s41...

Erythropoietin receptor on cDC1s dictates immune tolerance - Nature The tolerogenic activity of type 1 conventional dendritic cells (cDC1s) is determined by EPOR, which is preferentially expressed in cDC1s and induces antigen-specific FOXP3-expressing regulatory T cells.

Nature research paper: Erythropoietin receptor on cDC1s dictates immune tolerance

go.nature.com/496nEob

David Baltimore obituary: virologist whose enzyme discovery transformed understanding of cancer and HIV/AIDS The protein, reverse transcriptase, has become an essential tool for making DNA copies of RNA.

Obituary: David Baltimore (1938-2025) virologist whose enzyme discovery transformed understanding of cancer and HIV/AIDS

go.nature.com/443Vojo

Guess we DO, @ms-balzer.bsky.social

Secondary Necrosis Following Caspase‐Activation can Occur Independently of Gasdermin E Secondary necrosis follows apoptosis, but its mechanism is unclear. This study shows that although gasdermin E is cleaved during this process, it is not required for membrane rupture. Across multiple...

Secondary Necrosis Following Caspase‐Activation can Occur Independently of Gasdermin E - Gavali - Advanced Science - Wiley Online Library advanced.onlinelibrary.wiley.com/doi/10.1002/...

Congrats to the wonderful Sid Balachandran and team!

www.nature.com/articles/s41...

Registration is open: register for the first #MMPUResearchDay taking place in #Mannheim at #CubexOne on Oct 13, 2025. A great line-up of scientists from #MMPU, #EMBL, #UMM, #UKHD.

Hydroxyestradiol alleviates acute kidney injury via blockade of ferroptosis The molecular mechanisms underlying sex differences in acute kidney injury (AKI) remain incompletely understood. In a study recently published in Natu…

Very pleased to share this "spotlight" in Trends in Endocrinology and Metabolism which refers to our recent work.

www.sciencedirect.com/science/arti...

I do, indeed!

Oestradiol-mediated ferroptosis defense shapes sex differences in acute kidney injury - Cell Death & Differentiation Cell Death & Differentiation - Oestradiol-mediated ferroptosis defense shapes sex differences in acute kidney injury

Here is a "highlight" on our recent work written by Boyi Gan for Cell Death and Differentiation:
www.nature.com/articles/s41...

Warum Frauen seltener ein akutes Nierenversagen erleiden – Deutsches Ärzteblatt

www.aerzteblatt.de/news/warum-f...

Estrogen-powered kidney protection Estrogen protects against kidney injury through both genomic and nongenomic mechanisms.

This refers to our recent manuscript.
Estrogen-powered kidney protection | Science Signaling www.science.org/doi/10.1126/...

STING drives #necroptosis, and here’s how it does it!
Congratulations to @gianmaria-liccardi.bsky.social and his amazing team!

www.nature.com/articles/s41...

Multiple oestradiol functions inhibit ferroptosis and acute kidney injury - Nature 17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.

Happy to start at Bluesky with a post on our recent manuscript at @nature.com:

www.nature.com/articles/s41...

Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.

Hot off the presses! Was an honor to team up with Scott Dixon @stanforduniversity.bsky.social on this Nature Cancer review. We reflect on hurdles that have slowed translation of ferroptosis-directed therapies and share ideas on what it will take to bring these therapies to the clinic. rdcu.be/eBbqV