Elias Spiliotis's Avatar

Elias Spiliotis

@septinlab.bsky.social

Professor of Cell Biology (University of Virginia), Research Scientist. Science, music, sports and politics. Opinions are my own and not of my lab or university.

1,388 Followers  |  1,831 Following  |  261 Posts  |  Joined: 20.11.2024
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Posts by Elias Spiliotis (@septinlab.bsky.social)

Sad news indeed. Pioneer of the genomics era as we know it (genetic linkages/microarrays), and in the cytoskeleton field (tubulin/actin) during the heyday of yeast genetics.

28.02.2026 23:34 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Well said, Philly.

28.02.2026 20:17 โ€” ๐Ÿ‘ 19    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

"Since Wilfrid Rallโ€™s seminal work was published in the 1960s, the field has increasingly appreciated that individual dendritic branches can act like neurons within a neuron"

Apical vs basal dendrite differentiation/polarity is so fascinating... and there is nearly zero cell biology about it.

28.02.2026 07:39 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

One more reason to Stand Up For Science next weekend:

www.standupforscience.net/march7

In DC or a city near you:

fight2win.standupforscience.net/Rallies-2026....

28.02.2026 07:15 โ€” ๐Ÿ‘ 13    ๐Ÿ” 7    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
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a man in a suit and tie says just saying in front of a map ALT: a man in a suit and tie says just saying in front of a map

We need a bioRxiv for review articles...

26.02.2026 14:49 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Measles was wiped out in the U.S. 25 years ago and now weโ€™re already past 1,000 cases in February because vaccination rates dropped below the safety line. This is what happens when public health gets gutted and people stop trusting basic science.

25.02.2026 14:13 โ€” ๐Ÿ‘ 10423    ๐Ÿ” 3269    ๐Ÿ’ฌ 492    ๐Ÿ“Œ 179
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Leader of Columbia Brain Institute Quits Over Friendship With Epstein

Dang. Feels like the Jessell story was (7 yrs ago) yesterday.

The money addiction in science is real...

And seems the haves can never have or get enough of it.

#SpreadTheWealth

www.nytimes.com/2026/02/25/n...

25.02.2026 11:36 โ€” ๐Ÿ‘ 2    ๐Ÿ” 1    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Wish I had a lawsuit against FedEx everytime they have screwed up my labโ€™s deliveries - examples include a cracked anti vibration optical table, a $800 dollar shipment of protein from Europe (holiday rates apply), multiple orders of perishable brain tissueโ€ฆ and the list goes on and on.

24.02.2026 09:55 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Please share widely--there are rallies planned across the nation--look for one near you

23.02.2026 14:14 โ€” ๐Ÿ‘ 7    ๐Ÿ” 5    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Angine de Poitrine - Sherpa (Live on KEXP)
YouTube video by KEXP Angine de Poitrine - Sherpa (Live on KEXP)

Woah. Just woah! ๐Ÿคฏ

youtu.be/sfDtfz7vXkY

21.02.2026 20:28 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Linking molecular tension and cellular tractions: a multiscale approach to focal adhesion mechanics - Communications Biology Simultaneous mapping of tractions and molecular tension reveals how cells coordinate forces across scales, from whole-cell mechanics to polarized force transmission within individual focal adhesions.

Linking molecular tension and cellular tractions: a multiscale approach to focal adhesion mechanics
www.nature.com/articles/s42...

21.02.2026 08:54 โ€” ๐Ÿ‘ 6    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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a man is sitting at a desk with a canon camera behind him ALT: a man is sitting at a desk with a canon camera behind him

Looking forward to research supply prices and subcharges going down effectively today...

(yeah, the ones levied to offset tariffs)

Holding my breath

20.02.2026 18:38 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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a man wearing a mardi gras mask with beads around his neck ALT: a man wearing a mardi gras mask with beads around his neck

Looking for bead baths - formerly known as water baths.

Anyone has any recommendations for good ones?

19.02.2026 13:30 โ€” ๐Ÿ‘ 0    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

"Republics that work" for 500

19.02.2026 11:32 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Mark Rothko canvas, red on red

Mark Rothko canvas, red on red

Happy year of the fire horse

[Mark Rothko, Red on Red, 1969]

17.02.2026 12:40 โ€” ๐Ÿ‘ 568    ๐Ÿ” 130    ๐Ÿ’ฌ 7    ๐Ÿ“Œ 6

๐Ÿ˜ฎ๐Ÿคฏ

17.02.2026 09:56 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Molecular Biology of the Cell (MBoC)

Just in caseโ€ฆ we are looking for submissions for special issue on septins in MBoC:

www.molbiolcell.org/cell-biology...

15.02.2026 11:36 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Septin-coated microtubules promote maturation of multivesicular bodies by inhibiting their motility - PubMed The microtubule cytoskeleton consists of microtubule subsets with distinct compositions of microtubule-associated proteins, which instruct the position and traffic of subcellular organelles. In the endocytic pathway, these microtubule-associated cues are poorly understood. Here, we report that in MD โ€ฆ

Exciting. Nice to see it out. We had tried to go after the AP3 connection in early days of grad student project but did not get too far and went on a different direction:
pubmed.ncbi.nlm.nih.gov/38668767/

15.02.2026 03:41 โ€” ๐Ÿ‘ 3    ๐Ÿ” 0    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 0

New preprint from us and our friends in the Odorizzi lab at CU-Boulder โ€“ we find an apparent role for septin cytoskeletal filaments and vesicle transport from the Golgi to the vacuolar lysosome in budding yeast.

15.02.2026 02:53 โ€” ๐Ÿ‘ 50    ๐Ÿ” 16    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 0

Proud and excited to share our work with the community! Helen @helenfoster.bsky.social Foster et al. study how #cilia axonemes are built. ๐Ÿ‘€ Don't miss the gorgeous and insightful movies by @margotriggi.bsky.social, they really show our discoveries in full action!

www.biorxiv.org/content/10.6...

09.02.2026 20:03 โ€” ๐Ÿ‘ 74    ๐Ÿ” 26    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 2

โ€œFor instance, in 2013, Nathan Wolfe, then a virologist at Stanford University in California, proposed that Epstein fund a sexual-behaviour study of undergraduate students to test โ€œour horny virus hypothesisโ€ โ€” that certain vaginal and penile microorganisms might drive increased sexual activity.โ€

08.02.2026 12:08 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Kaitlan Collins is amazeballs in her job. Stoic as a rock. Always on script, quick on her feet, ice in her veins. I am amazed how she does it. She's going to be THE journalist of the millenial generation. And he always gets questions from her. She's got his attention despite lashing out.

04.02.2026 05:42 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Lab Research Professional 2 UVA Spiliotis Lab in Charlottesville, Virginia, United States of America | Research at University of Virginia Apply for Lab Research Professional 2 UVA Spiliotis Lab job with University of Virginia in Charlottesville, Virginia, United States of America. Research at University of Virginia

My laboratory (www.spiliotislab.org) at University of Virginia is hiring a new Lab Specialist.

Looking for candidates with experience in cell & molecular biology, biochemistry, and/or lab management.

Join us in scenic Charlottesville, Virginia!

jobs.virginia.edu/us/en/job/R0...

03.02.2026 23:41 โ€” ๐Ÿ‘ 1    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Colleges See Major Racial Shifts in Student Enrollment

Interesting data

www.nytimes.com/2026/02/03/u...

03.02.2026 11:43 โ€” ๐Ÿ‘ 2    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

๐Ÿ˜ฎ

31.01.2026 15:23 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Structure of the adaptor protein 4 (AP-4) complex revealed! AP-4 exists in a dynamic equilibrium between closed and open conformations in solution. ARF1 does not shift this equilibrium but is requiredโ€”together with cargoโ€”for membrane recruitment. rdcu.be/e1ozM

29.01.2026 21:53 โ€” ๐Ÿ‘ 22    ๐Ÿ” 10    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

๐Ÿ‘‡New biosketch requirement update.

โ€œAfter evaluating the number and types of recent technical inquiries we received to both the SciENcv and eRA Service Desks, we recognize the difficulties these issues have had on the communityโ€™s ability to comply with the original timeline of January 25, 2026.โ€
๐Ÿ‘‡

29.01.2026 22:08 โ€” ๐Ÿ‘ 26    ๐Ÿ” 19    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 3
Bruce Springsteen - Streets Of Minneapolis (Official Audio)
YouTube video by Bruce Springsteen Bruce Springsteen - Streets Of Minneapolis (Official Audio)

I wrote this song on Saturday, recorded it yesterday and released it to you today in response to the state terror being visited on the city of Minneapolis. Itโ€™s dedicated to the people of Minneapolis, our innocent immigrant neighbors and in memory of Alex Pretti and Renee Good.

Stay free

28.01.2026 17:02 โ€” ๐Ÿ‘ 97507    ๐Ÿ” 40913    ๐Ÿ’ฌ 4304    ๐Ÿ“Œ 5371

Keep on rockin in the free world...

27.01.2026 14:15 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

29,998 more to go... in the US

25.01.2026 18:03 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0