Another G-force molecule
GLP + glucagon agonist #pemvidutide in MASH
Resolution of MASH, fibrosis impact not seen at this time
www.thelancet.com/journals/lan... in @thelancet.com
How long till someone (?Pfizer) gobbles up Altimmune? @rnflex.bsky.social
EDITORIAL: Breaking Down Barriers to Reproductive Health Care in CKD
bit.ly/48wkB7l (FREE)
Happy to share that our abstract has been accepted for upcoming #ISNWCN
Maybe the most shocking study from #KidneyWk.
🐚From the depths of the oceans to #BlueSky, we're discussing PISCES 🐟 12/2/25 9pm EST. #NephJC
Are you hooked🪝on fish oil for CV disease in ESRD, or are you throwing it back 🌊?
www.nephjc.com/news/pisces-fishoil
My conference talk at the Kidney Foundation Dhaka, Bangladesh, concluded with an invitation to register for the upcoming WCN 2026, to be held from March 28–31 in Yokohama, Japan.
🐦⬛ Please note that the deadline for Early Bird Registration is January 24, 2026. #ISNWCN #ThisisISN
#Exome-wide Analysis Identifies a Rare #EXD3 Missense Variant Associated With #Diabetic #Kidney Disease
#VisualAbstract by Stephanie Torres
https://www.kireports.org/article/S2468-0249(25)00649-7/fulltext
Niina Sandholm
The #NephJC summary and VA are live
www.nephjc.com/news/atacice...
Excellent fast work from @notjustdialysis.bsky.social and @salinesolut.bsky.social
Atacicept in IgAN
1a/🌞Hello everyone, welcome to the #WorldDiabetesDay #skeetorial on behalf of @theisn.org @who.int
⁉️Let us begin with a quiz
🎊Do you know the theme of World Diabetes Day 2025?
a/ Breaking barriers, bridging gaps
b/ Family and diabetes
c/ Access to diabetes care
d/ Diabetes across life stages
📣 Save the date!
🗓️ October 28, 12pm EST
Join us for a Space on Tropical AKI, Part 2
🎧 Set your reminder twitter.com/i/spaces/1gq...
🧠 Before the session, test your knowledge!
Take the quiz 👉 theisn.outgrow.us/Tropical_AKI
Let’s see how much you know about Tropical AKI before the experts dive in! 💪🌴
Shubharthi from Bangladesh. No COI. #NephJC
September is #PCOSAwarenessMonth. Women who have polycystic ovary syndrome #PCOS have a risk of developing #preeclampsia in their #pregnancy.
Learn more here: www.preeclampsia.org/faqs
🎬 Share your story! Submit your short film for the 2026 #ISNFilmEvent — real stories from those affected by kidney disease and their care teams. Open to ISN members. Deadline: Nov 5 (midnight CET).
🎥 Info & submissions ➡️ http://lite.spr.ly/6... #ThisIsISN #ISNWCN
1/ July 16 is #WorldSnakeDay - raising awareness of the incredible diversity of snakes and their vital role in our ecosystems. But did you know snakebites can also cause acute kidney injury? Join me, Dr. Fong Voon Ken, as we discuss their impact, management, and the need for awareness.
𝗡𝗘𝗪 𝗥𝗘𝗦𝗢𝗨𝗥𝗖𝗘 𝗔𝗟𝗘𝗥𝗧: Download our #ADPKD infographic for a quick overview of diagnosis, delaying progression, complications & more. A handy resource for clinicians and patients alike!
⬇️https://www.theisn.org/wp-content/uploads/2025/07/ADPKD-Infographic.pdf
📢 The kidney community urges UN Member States to include kidney disease in the 2025 Political Declaration on NCDs & Mental Health.
🧬 850M affected
📈 5th leading cause of death by 2050
💡 Early care = 45% cost savings
📄 Read the letter: www.theisn.org/wp-co... #KidneyHealthMatters #HLM4 #NCDs
Interesting data from Alberta
www.kidney-international.org/article/S008... in @kidneyint.bsky.social
GFR < 15 is classified as ‘kidney failure’ in most studies - but about a third of them die before starting RRT.
Is that glass half full or half empty? 🥃
#NephSky
We don’t get to discuss every important study that comes out on #NephJC
Hence #NephJCShorts
www.nephjc.com/news/nephjc-...
⚡️Let’s have a closer look at the associations of each of these antigens
#ECNeph
@arvindcanchi.bsky.social
indianjnephrol.org/an-updated-r...
Now that’s a roll! Thanks for joining tonight’s #ECNeph discussion
@theisn.org @myadla.bsky.social @dramiliflores.bsky.social @arvindcanchi.bsky.social
⚡️PLA2R antibody seropositivity doesn’t mean that we do not investigate for underlying malignancies.
Here is a Case Report showing PLA2rAb MN having Carcinoma Oesophagus
#ECNeph
@theisn.org @myadla.bsky.social @dramiliflores.bsky.social @arvindcanchi.bsky.social
KDIGO recommends Population and Age-appropriate Screening for malignancies irrespective of antigen status
#ECNeph
@theisn.org @myadla.bsky.social @dramiliflores.bsky.social @arvindcanchi.bsky.social
KDIGO Approach When to Biopsy in MN patients
#ECNeph
@theisn.org @myadla.bsky.social @dramiliflores.bsky.social @arvindcanchi.bsky.social @rheaultm.bsky.social
3 approaches Contd
2. Panel approach: Alternatively, a laboratory could employ a standard panel of antibodies for antigens that can vary depending on volume and demographics
3. Proteomic approach: Laser microdissection of MN glomeruli, followed by mass spectrometry. #ECneph
3 approaches suggested by the Mayo clinic consensus report
1. Targeted approach: Perform antigen testing based on clinical disease association
Cont #ECNeph
www.kidney-international.org/article/S008...
Here’s a timeline of the auto-antigens found in MN
#ECNeph
@theisn.org @myadla.bsky.social @dramiliflores.bsky.social @arvindcanchi.bsky.social
indianjnephrol.org/an-updated-r...
👉 🫣 Can IF differentiate from Primary and Secondary MN?
IgG 4 is the dominant class in primary MN
👉 IgG1,IgG2, IgG3 are dominant Immunoglobulins in Secondary MN
#ECNeph
@theisn.org @myadla.bsky.social @dramiliflores.bsky.social @arvindcanchi.bsky.social
👉 MN is a pattern of glomerular injury
👉 Deposition of immune complex along subepithelial aspect of GBM
👉 On Light Microscopy GBM is thickened. GBM spikes or holes can be seen
👉 IHC/IF shows IgG with C3 along capillary wall
#ECNeph
@theisn.org @dramiliflores.bsky.social @arvindcanchi.bsky.social
If it is malignancy associated MN then no role of IS. Treatment of cancer is priority #ECneph
