Dell'Amico Group

We are delighted to share that our work on the use of ThioCarbonyl diFluorine (TCF) in photochemical reactions has now been officially published in Nature Communications !
Congratulations to all the authors and collaborators !
www.nature.com/articles/s41...

Recyclable IPN Photocatalysts Supported by Polymer Matrices: From Soluble Copolymers to Core-Polymer Brush Shell Nanostructures Functional polymeric materials have recently emerged as promising supports for organic photocatalysts (PCs), yet the effects of PC design and polymer architecture on catalytic performance remain underexplored. In this study, we present a versatile strategy for small-molecule activation using carbazolyl-dicyanobenzene-based PCs featuring an isophthalonitrile (IPN) core. These PCs feature thermally activated delayed fluorescence (TADF) properties and long-lived excited states, although they also suffer from an intrinsic chemical fragility that hampers their recyclability. A library of IPN derivatives was synthesized, characterized, and integrated into either soluble copolymers (by exploiting controlled radical polymerization) or grafted from inert silica nanoparticles (NPs) to yield PC-loaded spherical polymer brushes. Although soluble copolymers showed catalytic activity comparable to that of free PCs while testing model Povarov-type cycloadditions, PC recovery was only modest and relied on precipitation steps. In contrast, PC-loaded brushes on NPs achieved high yields and enabled efficient catalyst recovery and reuse (≥90%) over multiple cycles. This comparative approach highlights how the nature of the polymeric support, soluble vs. nanostructured, critically influences both catalytic performance and recyclability. More generally, the incorporation of IPN PCs into advanced polymer scaffolds is demonstrated to enhance their applicability, cost-efficiency, and sustainability.

A step forward toward more sustainable organic photocatalysis !! ♻️♻️
Here, you can check our last JACS publication (@jacs.acspublications.org) in collaboration with the Benetti's group. @unipd.bsky.social
shorturl.at/nnPdk

Want to put a bit of sweetness in your week ?? 🍰
Check out our new paper on a radical strategy to synthesize bicyclo[1.1.1]pentyl C-glycosides !!
Thank you to all the authors and collaborators for this work !
urlr.me/Pnwbj2

Photochemical Thiocarbonyl Difluoride Generation Enables Azetidine Synthesis The activation of amines into thiocarbamoyl fluorides (TCarbFs) provides access to valuable nitrogen-based functionalities. However, their broader use has been hindered by the reliance on harsh reagen...

New school year, New paper !
Check out our last preprint in @chemrxiv.org on the photochemical generation of Thiocarbonyl difluoride (TCF) for Azetidine synthesis. shorturl.at/m5Wjc

We are happy to share with you our most recent work related to the chemistry of difluorosulfoximination, published at @chemicalscience.rsc.org !

A great collaboration with the group of Prof. Emmanuel Magnier!

Congratulations to all the authors for the great job!
pubs.rsc.org/en/content/a...

Hello community! We decided to start our transition in the social media ocean. Apparently, this platform looks friendly and easy to operate!

The only thing we are sure of...we are ready to rock some cool chemistry!

We'll be in touch and may the force be with you!