Antonio Criscuolo

Presenting preliminary results on multimodal #body - #brain - #behavioral research at the #timing research forum conference, Tokyo

#rhythm #neuroscience

Yesterday we offered a workshop at the @timingresforum.bsky.social conference in Tokyo:

'Quantitative measures of #rhythm across disciplines: An overview and hands-on methodological approaches'

Thanks friends and colleagues: Marco Gamba, Yannick Jadoul, and Jelle van der Werff

Symposium on multimodal #body-#brain research in #auditory and #speech processing

Lesions in the cerebellum impact cross-modal temporal predictions The cerebellum (CE) supports the encoding of the precise sensory event timing and the generation of temporal predictions. Here we investigated whether focal CE lesions impact temporal predictions in a...

In this pre-print, we show that lesions in the #cerebellum (CE) impact motor-independent cross-modal #temporal #predictions

Co-authors: Franziska Knolle, Erich Schröger, Michael Schwartze, Rich Ivry, Sonja Kotz

www.biorxiv.org/content/10.1...

L-Dopa and STN-DBS modulate E/I balance and the neural encoding of rhythmic auditory stimulation in Parkinson Temporally regular auditory stimuli, such as metronome beats or music, are typically utilized in rhythmic auditory stimulation (RAS) to initiate and stabilize the precise temporal coordination of moto...

New pre-print: we show that L-Dopa and #DBS targeting the subthalamic nucleus have different effects on E/I balance and on the #neural encoding of #rhythmic auditory stimulation in #Parkinson's disease

doi.org/10.1101/2025...

What happens when our stream of consciousness turns inward, towards the body? Our new fMRI study of 536 individuals finds that 'body-wandering' is associated with distinct patterns of brain connectivity, physiology, affect, and mental health:
www.biorxiv.org/content/10.1...

4/n Finally, we delineate new emerging avenues for #multimodal, functional, #ecologically valid, and #personalized research that also integrates smart sensing technologies

3/n We review evidence showing that neurocognitive functions are modulated by bodily signals at multiple temporal scales: from ultra-slow #circadian rhythm to #gastrointestinal, #cardiac and #respiratory activity.

2/n We try to address new questions about if and how #autonomic functioning, the coordination of #interoception and exteroception, #lifestyle and #dietary choices, #gut #microbiome composition, #hormonal cycles, and #inflammation can impact behaviour, general #health and #wellbeing.

1/n We introduce the concept of a #body-#brain (dis) #equilibrium regulating transitions from #health to #pathology

@maastrichtu.bsky.social, Sonja Kotz, Anna M. Czepiel
NWO (Dutch Research Council): doi:10.61686/HNUXR80789

Link to article: doi.org/10.1016/j.pl...

Thanks @artinis.bsky.social,
@maastrichtu.bsky.social and Maastricht Convention Bureau for support!
I also want to thank everyone who joined for exciting discussions!
Stay tuned for next events: waves-conference.com

2 conference days followed by a science dissemination event:

#brain #metabolism, #gut #microbiota, #gutbrain axis, #nutrition (and #food supplements), subjective #distorsions of #body / #food (in eating disorders, e.g., #anorexia and #obesity), and methods: #EGG, ingestible smart #pills, #tVNS

3/n If you're interested in joining the conference online, get in touch!

Thanks Artinis Medica Devices and Maastricht Convention Bureau for the support!

Conference will take place at
@maastrichtu.bsky.social

2/n General overview of the conference program: shorturl.at/PgCn1
Link to our website: waves-conference.com
Link to register for the public outreach event (in person): lnkd.in/gZ469HSM

1/n The III edition of the #Body-#Brain #Waves conference series is taking place in a few weeks in Maastricht!

27-28th June: conference days (hybrid format)
29th June: free #science #dissemination event

#nutrition, #gut-brain axis, gut #microbiota, #cognition

5/n We suggest that #hypersensitivity to loudness changes may underlie IwPD’s difficulties in processing and adapting their voice acoustics.

Thanks co-authors from:
@BANDLabUM

@maastrichtu.bsky.social @ub.edu Universidad de Valparaíso, Institut de Recerca Sant Joan de Déu

4/n Mixed model analyses showed that IwPD displayed hypersensitivity (larger N100 error responses) to unexpected loudness modulations as compared to HC. This observation suggests that IwPD may process voice modulations differently than HC.

3/n Here, we recorded #EEG from IwPD and matched controls while they engaged in a voice playback paradigm with three conditions: self-generated (hear the voice when you tap), externally generated (no tap), and loudness manipulation (+15dB).

2/n We hypothesized that difficulties may arise from compromised sensory #feedback: the inability to efficiently process, predict and adapt to sensory input during speech, may impact the capacities to monitor and adjust parameters such as loudness, pitch, and articulation

Heightened Sensitivity to Voice Loudness Changes in Parkinson's Disease Parkinson's disease (PD) affects voice and speech production, often resulting in reduced vocal intensity and monotonous speech. Recent studies have suggested that these changes can be partially explai...

1/n #Speech production in individuals with #Parkinson’s disease (IwPD) is often marked by hypophonia and hypokinetic dysarthria, which affects #voice modulation and articulation, negatively impacting #communication and quality of life.
www.biorxiv.org/content/10.1...

This looks super useful from an #interoceptive perspective:

A systematic review of autonomic dysfunction studies in Parkinson's Disease, from @antocris.bsky.social Alice Pelucchi Michael Schwartze and Sonja Kotz 🧠🫀🫁

#neuroskyence
www.researchsquare.com/article/rs-6...

4/n We just posted our pre-print: shorturl.at/LEjKR

Connect with me and the BANDLab (PI: Sonja Kotz) either here, on LinkedIn (linkedin.com/in/antonio-c...) or email: a.criscuolo@maastrichtuniversity.nl

3/n Overall, we find strong convergence for an imbalance of #sympathetic and #parasympathetic activity, suggesting a central role of autonomic dysfunctions on PD pathogenesis.
These observations call for integrative, individualized and longitudinal #body-#brain research

2/n Most studies (85%) show #cardiovascular changes, along with dysfunctions in #breathing (15%; frequency and resistance), #olfaction (hyposmia - anosmia), #skin (9%; thermoregulation and pilomotor functions), #sleep (15%; RSWA, iRBD, SAS), and #circadian (9%) regulation

1/n Beyond the well-characterized #neuro-anatomical, -functional and -#cognitive changes, 50-70% of individuals with #Parkinson's Disease (PD) exhibit #autonomic #dysfunctions.
We performed a systematic #review: shorturl.at/LEjKR

Registration for #Waves finally open!
How does #nutrition impact #gut - #brain #health, gut-brain axis, gut #microbiota?
Join as a listener or as a speaker: application for talks extended.
Reduced prices for researchers in the NL, Italy and teams: www.waves-conference.com/#registrations

Neural mechanisms of predictive processing: a collaborative community experiment through the OpenScope program This review synthesizes advances in predictive processing within the sensory cortex. Predictive processing theorizes that the brain continuously predicts sensory inputs, refining neuronal responses by...

A large-scale collaborative consensus piece on predictive processing is now online arxiv.org/abs/2504.09614 impressively orchestrated by @jeromelecoq.bsky.social

Final days to apply for a talk. Registrations open soon

Get ready for this focused meeting on #nutrition, #gut, #brain, #cognition and #health in the NL

Only 150€ to join us in Maastricht - get in touch to know more!

www.waves-conference.com

We show that #aging impacts basic #auditory and #timing processing.
Increased cortical #excitability (E/I balance), heightened sensory #sensitivity, but reduced phase-alignment of ongoing delta-band neural oscillatory activity in healthy aging as compared to young adults

lnkd.in/dmdhWP3P

We show impaired neural tuning #dynamics to an isochronous #rhythm in #stroke patients: lesions in the #basalganglia and #cerebellum increase variability in event-related response, reduce delta-band phase coherence and stability while synchronizing to temporal regularities

doi.org/10.1162/imag...