José Luis Sardina

Really enjoyed visiting CABD (@cabd-upo-csic.bsky.social) in Sevilla last Friday — great discussions and inspiring science. I shared our group’s latest work on #epigenetics, #cellfate, #CRISPR and #leukemia.

Thanks to Ozren (@obog.bsky.social) for being a great host!

#CABDseminars

"Rewriting Cell Identity Through TET2 Chromatin Profiling and DNA Methylation Editing" by José Luis Sardina @jlsardinalab.bsky.social, @carrerasijc.bsky.social

🗓️ November 7th
⏰ 12 pm
📍sala Grado, edificio 25 (biblioteca UPO) ‼️

Hosted by @obog.bsky.social

New paper alert – now in @ScienceAdvances

Congrats to IMMERGE PI José Luís Sardina and team!🎉
This study shows how targeted DNA methylation editing at a key immune gene can reshape cell fate and immune responses.

📷 Read more: pubmed.ncbi.nlm.nih.gov/40668918/
#IMMERGE #MSCA #CRISPR #epigenetics

Congratulations, Dr Obiols! 👩‍🔬

Mireia Obiols, researcher at the @jlsardinalab.bsky.social, has successfully defended her #PhD thesis today at the IJC Auditorium.

Proud of your dedication and hard work 💪

🚀The IMMERGE consortium met in Heidelberg for our 2nd training event & Midterm Review!

DCs joined sessions on:
🔬Epigenetic & Transcriptional Regulation
🧠Leadership & Management

Huge thanks to all involved—and to @embl.org for hosting us!

🌍Next stop: Milan!
👉 immergeproject.eu

#IMMERGE #MSCA

🔬 Passionate about experimental hematology?

Apply now for the final @carrerasleaders.bsky.social Call and join our team to work at the intersection of epigenetics, chromatin biology, and blood cancer.

#Hematology #Epigenetics #postdoc

Learn more (shorturl.at/5x5sw) & Apply 👇

🔬 Meet the Researchers Behind IMMERGE! 🔬

This week: Renata Chalupska & Dr. Saka from @embl.org 🧬
Renata investigates how immune monogenic syndromes impact blood cell development.

That’s a wrap on our IMMERGE series—13 brilliant researchers shaping immunology’s future! 🌍👏

#IMMERGE #MSCA #IEI

🔬 Meet the Researchers Behind IMMERGE!🔬

This week: Martí Leira & Dr. Vento-Tormo from @sangerinstitute.bsky.social!🧬
Martí explores novel regulators of Tregopathies to better understand immune dysregulation and its roots.

Stay tuned for more IMMERGE scientists! 🚀

#IMMERGE #MSCA #IEI

🔬 Meet the Researchers Behind IMMERGE! 🔬

This week: Eric O'Shee & Dr. Geiger from IRB! 🧪✨
Eric studies how mutations linked to Treg dysfunction impair immune suppression, disrupt immune tolerance, and contributing to autoimmunity.

Stay tuned for more IMMERGE scientists! 🚀

#IMMERGE #MSCA #Tregs

🔬 Meet the Researchers Behind IMMERGE! 🔬

This week: Franka Witthauer & Dr. Casini from Alia Therapeutics! ✨
Franka works on correcting mutations linked to primary immunodeficiencies using innovative, engineered CRISPR tools.👩‍🔬

Stay tuned for more IMMERGE scientists! 🚀

#IMMERGE #MSCA #IEI #CRISPR

🔬 Meet the Researchers Behind IMMERGE! 🔬

This week: Tharaa Mohammad & Dr. Rodriguez from qGenomics! 🧬
Tharaa studies how JAK/STAT and NF-κB signaling contribute to immune-related preeclampsia, uncovering maternal-fetal immune dynamics.

Stay tuned for more IMMERGE scientists! 🚀

#IMMERGE #MSCA #IEI

Check out Epigenetic Control of Hematopoiesis lab led by Dr.
@jlsardinalab.bsky.social.

Eager to contribute to impactful research at the intersection of epigenetics, chromatin biology, and hematology? They’d love to hear from you!

Get in touch by June 1!
More: carrerasleaders.eu

#MSCA #postdoc

📢Looking for a #postdoc in blood cancers?

The CarrerasLeaders Call 4 is OPEN for exceptional applicants at @carrerasijc.bsky.social.

📅 Apply by June 1, 2025

✨World-class researchers supervision
✨International secondments
✨Top-tier research infrastructures

More details at carrerasleaders.eu

Mutant CEBPA promotes tolerance to inflammatory stress through deficient AP-1 activation - Nature Communications CEBPA is frequently mutated in acute myeloid leukemia (AML), but the transcriptional impact of the AML-associated isoform remains unclear. Here, the authors show that CEBPA-mutant cells have reduced i...

Extremely happy to share that the first paper from our lab is now published! Driven by the very talented PhD student Maria Cadefau, we studied how CEBPA mutations shape transcriptional programs in AML. A thread 🧵👇

www.nature.com/articles/s41...

🔬 Meet the Researchers Behind IMMERGE! 🔬

This week: Florence Melbert, @eballestar.bsky.social & @jlsardinalab.bsky.social from @carrerasijc.bsky.social!
Florence is studying how IKAROS mutations contribute to IEI.👩‍🔬

Stay tuned for more IMMERGE scientists! 🚀

#IMMERGE #MSCA #IEI #IKAROS

🔬 Meet the Researchers Behind IMMERGE! 🔬

This week: Andrea Carpinteiro & Dr. Di Micco from OSR! 🧬
Andrea explores how dysfunctional telomeres impact stem cells & immunity, revealing links between aging and immune regulation.

Stay tuned for more IMMERGE scientists! 🚀

#IMMERGE #MSCA #IEI #Telomeres

🔬 Meet the Researchers Behind IMMERGE!🔬

This week: Laura Artal & Dr. Klaus Warnatz from @uni-freiburg.de! Laura will focus on IKBKB deficiency, aiming to uncover its impact on patients with immunodeficiencies 🧬✨

Stay tuned for more IMMERGE scientists! 🚀

#IMMERGE #MSCA #IEI #Immunology #IKBKB

🔬 Meet the Researchers Behind IMMERGE! 🔬

This week: @angelopilotti.bsky.social & Dr. Pierre from @cnrs.fr!
Angelo will study the functional impact of EIF2AK mutants in dendritic cells & interferonopathies🧬👨‍🔬

Stay tuned for more IMMERGE scientists! 🚀

#IMMERGE #MSCA #IEI #DCs #Interferonopathies

🔬 Meet the Researchers Behind IMMERGE! 🔬

This week: Giulia Bressan & Dr. Bodo Grimbacher from @uni-freiburg.de!
Giulia will dive into STAT3 regulation & signaling to better understand immune function👩‍🔬🌟

Stay tuned for more IMMERGE scientists! 🚀

#IMMERGE #MSCA #IEI #Immunology #STAT3

🔬 Meet the Researchers Behind IMMERGE! 🔬

This week: Emily Flaschner & Dr. @jlsardinalab.bsky.social from @carrerasijc.bsky.social!
Emily's research explores TET-mediated epigenetic control in NF-κB mutated patients👩‍🔬🌟

Stay tuned for more IMMERGE scientists! 🚀

#IMMERGE #MSCA #Epigenetics #NFkB #IEI

Celebration Tuesday! 🥳

🎉 Congratulations to Gemma Varcárcel 👩‍🎓 (Dr. JL Sardina's lab) who has successfully defended her #thesis in how to use gene editing tools to influence immune cell differentiation and function, a promising approach against cancer 👏