Hi Jongmin, thanks! That's an interesting possibility. Based on the reported Polycomb abundance measurements, Polycomb protein occupancy seems likely too low to be able to block loop extrusion. It would be super interesting to look at E-P loops in cell lines +/- degrons to get more insights on this!
23.02.2026 18:03 β π 1 π 0 π¬ 0 π 0
I had a lot of fun putting this together with @suminkim.bsky.social and @andersshansen.bsky.social! Glad to have had the chance to work on it!
19.02.2026 01:37 β π 26 π 9 π¬ 1 π 2
Happy to share our new review on Polycomb-mediated 3D chromatin interactions! Thanks to @mileshuseyin.bsky.social and @andersshansen.bsky.social for great discussions throughout the process :)
19.02.2026 00:57 β π 17 π 5 π¬ 0 π 0
Very cool!
18.12.2025 04:44 β π 1 π 0 π¬ 0 π 0
Sosa Lab - Postdoctoral Researchers
We are seeking postdocs to start in 2026!
The Sosa Lab is going to #SfN25 and actively recruiting β¨postdocsβ¨ with systems neuroscience experience! We study both fundamental memory processes and how memory changes during pregnancy and postpartum.
If you are interested in meeting at SfN, please email me! www.sosaneurolab.com/join/postdoc...
07.11.2025 22:53 β π 77 π 49 π¬ 1 π 1
Amazing! Congratulations!!!! π
07.11.2025 13:03 β π 1 π 0 π¬ 1 π 0
β€οΈ
06.11.2025 03:11 β π 1 π 0 π¬ 0 π 0
Thank you!!
28.05.2025 01:46 β π 1 π 0 π¬ 0 π 0
Thanks Mara!
28.05.2025 01:46 β π 0 π 0 π¬ 0 π 0
Thank you!
28.05.2025 01:46 β π 1 π 0 π¬ 0 π 0
Excited to be a part of this amazing community!
27.05.2025 18:53 β π 4 π 0 π¬ 2 π 0
Genome structure mapping with high-resolution 3D genomics and deep learning
Gene expression is often regulated by distal enhancers through cell-type-specific 3D looping interactions, but comprehensive mapping of these interactions across cell types is experimentally intractab...
Excited to share my first preprint from the @andersshansen.bsky.social lab! It's got genomics, AI, and biology - all wrapped up in a great paper. Also very grateful to my amazing collaborator, Fan, for all his hard work. Please check it out and let me know what you think!
tinyurl.com/bdfvtd6f
07.05.2025 18:50 β π 29 π 6 π¬ 1 π 2
(1/n) New preprint from @claricehongky.bsky.social
Fan Fang Varshini Ramanathan in collab w Jie Liu.
Q: How do we get ultra-high-res 3D genome maps?
A: New deep learning model, Cleopatra.
Cleo trains on Micro-C, fine-tunes on RCMC, and predicts genome-wide 3D maps at ultra-high resolution.
07.05.2025 20:54 β π 65 π 23 π¬ 3 π 0
(1/n) Thread @matteomazzocca.bsky.social @domenicnarducci.bsky.social Simon Grosse-Holz @jessematthias.bsky.social preprint
Q: how does chromatin move?
Using MINFLUX, SPT & SRLCI, we track chromatin dynamics across 7 orders of magnitude in time to provide answers www.biorxiv.org/content/10.1...
15.05.2025 12:37 β π 68 π 22 π¬ 2 π 1
1/
Super excited to share my first preprint from @andersshansen.bsky.social Lab! We used MINFLUX to track chromatin (H2B-Halo and Fbn2 locus) at an unprecedented 200β―ΞΌs, then combined it with SPT to span ΞΌs-minutes (H2B) or SPT & Super-Res Live-Cell Imaging (SRLCI) to span ΞΌs-hours (Fbn2)
14.05.2025 17:58 β π 29 π 11 π¬ 1 π 4
Retired researcher in Developmental Genetics, Evo-Devo. Drosophila. Polycomb Group. (PRC genes. Finder of "polyhomeotic"), Nuclear transplantation in the egg. Cell mosaics and chimeras. Epigenesis in Drosophila. CSIC --> CNRS. Hobby: mosaics.
Group Leader @ BIH Berlin and MPI Molecular Genetics. I play around with DNA because Iβd like to know how the genome functions.
π» 𧬠3D genome & RNA lovers Group Leader at Center for Human Technologies, Italian Institute of Technology | CDA @ArmeniseHarvard
ICREA Research Professor. Evolution, Genetics, Neuroscience, Linguistic Cognition
https://www.cedricboeckx.com
Assistant Professor @Cornell University
- Germline gene regulation, gene silencing, chromatin
- jongminkimlab.org
De novo protein design aficionado.
Genomics, AI, sequence-to-function models, mechanisms of the cis-regulatory code. Investigator at the Stowers Institute.
Postdoc in the Ε»ylicz group at reNEW Copenhagen, formerly in Brand lab at University of Cambridge/NYU Langone;
chromatin, stem cells and metabolism π¬π§¬
Lise Meitner Research Group Leader @ Max Planck Institute for Multidisciplinary Sciences
Genome Organisation and Regulation
She/her
Group leader @mpi-mg, Berlin
Chromatin tracing, epigenetics, development. Equity and advocacy in academia.
Scientist interested in chromatin and regulation of transcription. Klose lab, University of Oxford
Postdoc in epigenetics and gene regulation @DavidovichLab, Monash University. Current focus on PRC2, RNA and chromatin dynamics; former research on mRNA export.
Postdoc in Anders Hansen lab at MIT. Previously PhD with Rob Klose. Interested in regulation of transcription and dynamics at single molecule level.
Professor of Genetics
Department of Biochemistry
University of Oxford
kloselab.co.uk
Brandeis Biology, Assc. Prof,epigenetic inheritance,protein QC, learning to cope with uncertainty, hoping good coffee helps, thinking about poetry and those who do not have the permission to narrate.he/him http://www.ragunathanlab.org
CNRS Senior Researcher - Group Leader at Laboratory of Biology and Modeling of the Cell, Ecole Normale SupΓ©rieure de Lyon.
Physical biology of chromatin: modeling the spatio-temporal dynamics of eukaryotic genomes.
Postdoc at UNC Chapel Hill β’ American Cancer Society, LβOrΓ©al FWIS, & Leading Edge Fellow β’ Stony Brook University alum β’ Passionate about cell & developmental biology, C. elegans, science communication, & outreach β’ tmedwigkinney.com
Assistant Professor @Columbia University | Ribosome, translation, RNA, CRISPR, genomics | alum @MIT @WhiteheadInst @Tsinghua_Uni | #hiringNow
xuebingwu.github.io
Enhancers, 3D genome organisation, pluripotent stem cells
Babraham Institute and Enhanc3D Genomics
