@chiarastringari.bsky.social
Scientist at @cnrs.bsky.social @laboptbio.bsky.social https://lob.ip-paris.fr/en/chiara-stringari Label-free optical microscopy and metabolic imaging. 'Science doesn't care about what you believe'
For the next LOB seminar @joergenderlein.bsky.social from Georg August University in Göttingen will present : “Fluorescence-Lifetime Super-Resolution Microscopy”.
See you on February 26th at 11:00am in Amphi Becquerel.
lob.ip-paris.fr/en/events/se...
Exciting science and discussion during the "Young Lobsters Day" (19/02)
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Des discussions scientifiques passionnantes pendant le "Young Lobsters Day" (19/02)
Next LOB seminar: 12 Feb. 2026, 11:00AM, @xpolytechnique.bsky.social, Amphi Becquerel
Seminar of @lorenaguilarlab.bsky.social from UNAM
Title: Metabolic State as a Regulator of Transcriptional Dynamics in Human Embryonic Stem Cell Differentiation
lob.ip-paris.fr/en/events/se...
📢 LOB Seminars are back!
🗓 29 Jan 2026 | 11:00am
📍 Amphi Poisson
🎤 Baptiste Blochet (Saint-Pérès Paris Institute for the Neurosciences – SPPIN)
“Multiplexed Phase Imaging: From Laser Metrology to Super-Resolution Microscopy”
Looking forward to seeing you there!
lob.ip-paris.fr/en/events/se...
Congratulations to all the authors @baharasadipour.bsky.social Joséphine Morizet @remironzano.bsky.social Xingjian Zhang Aigrot Marie-Stéphane Pierre Mahou Xavier Solinas @MinhSonPHAN Minh Son PHAN @anatolechessel.bsky.social Bruno Stankoff Anne Desmazieres @ebeaurepaire.bsky.social
07.01.2026 16:31 — 👍 3 🔁 0 💬 0 📌 0Our label-free multimodal imaging approach combines THG myelin imaging, NAD(P)H FLIM, and advanced automated analysis to simultaneously quantify myelin architecture and cellular metabolism in living brain tissue, revealing cell-specific metabolic signatures and changes during demyelination.
07.01.2026 16:28 — 👍 3 🔁 0 💬 1 📌 0
Our paper “Label-free nonlinear microscopy probes cellular metabolism and myelin dynamics in live tissue” is published in @commsbio.nature.com, thanks to an exciting collaboration between @laboptbio.bsky.social and @institutducerveau.bsky.social
www.nature.com/articles/s42...
Optical redox ratio coded images from a cervical epithelial tissue.
💡 New guidelines aim to standardize label-free optical metabolic imaging, a technique that uses light to study cell metabolism without dyes.
Consistency could lead to more accurate, reproducible results in cancer & drug development research. Read the #SPIE_JBO article: https://bit.ly/4isPMFc
L'équipe de microscopie avancée du @laboptbio.bsky.social
adossée à la platforme Morphoscope du noeud Ile-de France-Sud de @france-bioimaging.bsky.social, est à la recherche d'un IR en bioimage informatique.
emploi.cnrs.fr/Offres/MOBIN...
Congratulations to Poncia Nyembo Kasongo on the brilliant defense of his PhD thesis "Second Harmonic Generation Imaging of the Structure of Healthy and Pathological Corneas" !
28.11.2025 18:17 — 👍 6 🔁 1 💬 0 📌 0
Screenshot of the article linked to in the post. It shows the headline and some introductionary text: "Proposed actions against fake science presented after meeting Today, Dan Larhammar, Uppsala University and former president of the Academy, and Bernhard Sabel from Otto von Guericke University in Magdeburg, Germany, have published the Stockholm Declaration, which outlines a number of proposed countermeasures against fake science, often produced by AI. This growing problem was discussed early this summer at a workshop held at the Royal Swedish Academy of Sciences." Below that a group photo of the attendees on the steps of the main building of the Royal Swedish Academy.
This is the result of a meeting held this summer in Stockholm, organized by the Royal Swedish Academy of Sciences, where I was one of the attendees.
Proposed actions against fake science presented after meeting
www.kva.se/en/news/prop...
More press @FinancialTimes [Gift link]:
A tide of fabricated research risks scientific integrity
Manipulation, disinformation and fakery could lead to a knowledge collapse
www.ft.com/content/a1c6...
Reformation of science publishing: the Stockholm Declaration
A call to action for universities, academies, science organizations and funders to unite and join this effort.
Bernhard Sabel and Dan Larhammar
royalsocietypublishing.org/doi/10.1098/...
Grateful for the collaborative efforts of our global team and the progress this represents for the field. A special thank to Irene Georgakoudi for leading this work.
17.11.2025 10:53 — 👍 1 🔁 0 💬 0 📌 0
Excited to share that our international consensus guidelines for cellular, label-free optical metabolic imaging have been published in the Journal of Biomedical Optics.
www.spiedigitallibrary.org/journals/jou...
#metabolicimaging #labelfree
A red fluorescent genetically encoded biosensor for in vivo imaging of extracellular l-lactate dynamics
www.nature.com/articles/s41...
Wrapping up #Mifobio2025!
What I love most about this conference is how it reminds me that science is, above all, a collaborative effort. Nothing beats the sense of community here. See you in 2 years!
Check the Imabio @gdrimabio.bsky.social website for course and seminar replays soon imabio-cnrs.fr
Here you can find the slides of the MIFOBIO 2025 Workshop "A-07 Analyzing FLIM data for metabolic imaging applications with Phasor Analysis" using FLUTE software, with Xiaotong Yuan.
zenodo.org/records/1736...
#mifobio2025
Amazing talk on “Mechanobiology of the Mitotic Spindle” by @ivatolic.bsky.social at #mifobio2025 @gdrimabio.bsky.social
15.10.2025 20:44 — 👍 12 🔁 2 💬 2 📌 0
(2025/10/08) Congratulations to @chiarastringari.bsky.social on the defense of her Habilitation à Diriger les Recherches (HDR) "Label-free multimodal non-linear optical microscopy for functional imaging of living tissues" !
09.10.2025 09:50 — 👍 13 🔁 4 💬 0 📌 0
Over a decade at @laboptbio.bsky.social at @polytechniqueparis.bsky.social !
03.09.2025 11:58 — 👍 9 🔁 0 💬 0 📌 0Happy to finally publish this work… Congrats authors and thanks funders @agencerecherche.bsky.social #FondationBettencourtSchueller
16.07.2025 13:39 — 👍 5 🔁 1 💬 0 📌 0
These findings help to establish THG microscopy as a quantitative, multiscale imaging technique, paving the way for new applications. 📖 #Neuroscience #Myelin #THG #Microscopy #Research
16.07.2025 13:39 — 👍 5 🔁 1 💬 1 📌 0Fun fact for multiphoton microscopy geeks: aberrations caused by vertical micro-interfaces appear to be a significant contrast mechanism in polarized THG imaging. 😎
16.07.2025 13:39 — 👍 12 🔁 3 💬 1 📌 0
Finally, we illustrate the relevance of pTHG microscopy for characterizing myelin distribution at different scales in fixed mouse and human brain tissue.
16.07.2025 13:39 — 👍 3 🔁 1 💬 1 📌 0
Our study presents a systematic characterization of polarized THG (pTHG) signals from individual axons, enabling the derivation of myelin scores in various systems. 🐭🐟
We confirm the sensitivity of THG for myelin in mouse tissue and detect early axon development in zebrafish.
We show that axons exhibit complex pTHG profiles that depend on axon morphology and can't be explained by classical models. We establish a numerical strategy to relate pTHG profiles to axon diameter and myelin thickness, taking into account myelin-induced optical aberrations.
16.07.2025 13:39 — 👍 5 🔁 1 💬 1 📌 0
Multiscale characterization of myelin distribution with polarized THG microscopy
Morizet et al, Optica 2025 doi.org/10.1364/OPTI...
@laboptbio.bsky.social @institutducerveau.bsky.social @cnrs.fr @ip-paris.bsky.social @inserm.fr
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By #J_Morizet #N_Olivier #MS_Aigrot #P_Mahou #E_Martin #A_Desmazieres #B_Stankoff @chiarastringari.bsky.social
🔬🌟 Find out how Third Harmonic Generation (THG) microscopy could help advance myelin biomedical research! 🧠
