Department of Metabolism, Digestion & Reproduction

Imperial hosts WHO Europe and EASL to strengthen action on steatotic liver disease Imperial College London hosted senior leaders from WHO Europe and the European Association for the Study of the Liver (EASL) to advance a coordinated...

MDR's Prof Mark Thursz & Dr Penny Manousou hosted @whoeurope.bsky.social & EASL to strengthen action on steatotic liver disease

Bringing policy, science & research together, the collaboration aims to turn evidence into real-world impact ⬇️
www.imperial.ac.uk/news/article... @grahamscooke.bsky.social

A new era for gut science begins at Imperial - Imperial Medicine Blog Imperial's Centre for Intestinal Systems (CIS) is a hub dedicated to advancing human-relevant gut research. Explore why the gut matters, how new technologies are reshaping the field, and how CIS aims ...

Your #gut doesn’t just digest food – it affects immunity, #metabolism + even mental health.

@imperialcollegeldn.bsky.social's Centre for Intestinal Systems aims to make gut research more human-relevant + more useful for patients.

👇 blogs.imperial.ac.uk/imperial-med... @imperialmdr.bsky.social

A large-scale comparison of clinical outcomes to IBD therapies in White and South Asian ethnicities While ethnic differences in IBD phenotype are recognised, the comparative efficacy and safety of common IBD therapies across ethnically diverse popula…

Great to see out this study from Sharmili Balarajah and Laura Martinez-Gili @imperialmdr.bsky.social, working with the #IBD @nihrbioresource.bsky.social, comparing outcomes with #IBD therapies in White and South Asian patients, now in @eclinicalmed.bsky.social: www.sciencedirect.com/science/arti...

Endometrial cancer is rising & early detection is hard.

An exciting new MDR-led paper shows that a mass-spec imaging method can accurately tell cancer from non-cancer tissue & may spot risk before cancer appears - potentially transforming diagnosis & surgery ⬇️
www.pnas.org/doi/abs/10.1...

“Understanding how glycans enable microorganisms to get a foothold in the vaginal microbiome offers new, exciting avenues for therapeutic design to prevent or encourage their binding and colonisation and hence improve women's health outcomes.” Dr Virginia Tajadura-Ortega, MDR

Identification and characterisation of vaginal bacteria-glycan interactions implicated in reproductive tract health and pregnancy outcomes - Nature Communications A study by Tajadura-Ortega et al. uses glycan microarrays to reveal how vaginal microbiota interacts with host glycans, offering insights into how glycan interactions influence bacterial colonization ...

"Our findings offer the first detailed insight into these complex glycan-bacteria interactions and open the door to broader microbiome research, not just for women’s health, but across diverse biological systems.” Dr Yan Liu, MDR

Read the Nature Communications paper: www.nature.com/articles/s41...

Shedding light on how bacteria and glycans interact in reproductive health | Imperial News | Imperial College London Cutting-edge glycan microarray technology reveals how beneficial and harmful bacteria interact with sugar molecules in the vaginal tract.

Shedding light on how bacteria and glycans interact in reproductive health

Research led by MDR uses cutting-edge glycan microarray technology to reveal how beneficial and harmful bacteria interact with sugar molecules in the vaginal tract. ⬇️

www.imperial.ac.uk/news/265414/...

A great privilege to work with @julieakmcdonald.bsky.social lab on this new paper, now out in @natureportfolio.nature.com Communications - how #antibiotic-related changes in gut #nutrients and #metabolites promote #VRE colonisation: doi.org/10.1038/s414... @imperialmdr.bsky.social

What's Up Docs? - Do I need testosterone? - BBC Sounds Drs Chris and Xand ask - what are the pros and cons of testosterone replacement therapy?

Great to hear MDR's own Dr Channa Jayasena on BBC Radio 4's ‘What’s Up Docs?’ podcast, talking about ‘Do I need testosterone?’ ⬇️

www.bbc.co.uk/sounds/play/...

YouTube video by Channel 4 Documentaries Britain's Skinny Jab Scandal | Dispatches | Channel 4 Documentaries

Interesting to hear MDR's Professor Tricia Tan comment on Channel 4's Dispatches: Britain's Skinny Jab Scandal ⬇️
youtu.be/bRVj5facefA?...

Great to be representing @robsinstitute.bsky.social in beautiful Singapore and meeting up with old friends/colleagues Phil Bennett (@imperialmdr.bsky.social) and Teoh TG (KK Women's and Children's Hospital) to discuss exciting new collaborations.

Celebrating MDR's Women - Dr Roberta Migale | Imperial News | Imperial College London To mark Women at Imperial Week, we interviewed three of MDR's outstanding female staff. In our final interview, we spoke to Dr Roberta Migale.

"If I had stopped at the first thoughts of self-doubt, I’d never be where I am now."

Dr Roberta Migale's career is a story of persistence & mentorship.

Discover how she’s supporting #WomenInSTEM & shaping reproductive health research ⤵️ www.imperial.ac.uk/news/261854/... @imperialmdr.bsky.social

The #MAST trial is pushing forward, investigating the impact of #IMT #FMT prior to #HCT in seven UK centres #HaemSky #MicrobiomeSky #GastroSky @imperialmdr.bsky.social @bloodcanceruk.bsky.social ruk.bsky.social @anthonynolan.bsky.social. Find out more from our poster or our website: rb.gy/myizsb

Call for vigilance after fertility treatment - Imperial Medicine Blog Fertility treatments like IVF help thousands of women achieve their dream of motherhood each year, but what are the long-term health implications? Dr Srdjan Saso explores what the data reveals, and ho...

#Fertility treatments like #IVF help thousands of women achieve their dream of motherhood each year, but what are the long-term health implications?

MDR's Dr Srdjan Saso explores what the data reveals & how clinics can improve long-term health monitoring ⬇️
blogs.imperial.ac.uk/imperial-med...

Pleased to see our review (w/ Cathrin Gudd & Lucia Possamai) on immune-mediated liver injury from checkpoint inhibitors published in @natrevgastrohep.bsky.social 's latest issue | @imperialmdr.bsky.social | #cancer #immunotherapy #liver #inflammation

Two graphs show the mean symptom score reported by people living with Long COVID or ME/CFS. The left graph shows menstrual cycle phase, with symptoms most severe before and during the menstrual period, and least severe at around the time of ovulation. The right graph shows less severe symptoms in people taking combined hormonal contraception, compared to none or progestin only.

948 users prospectively entered #MenstrualCycle & #LongCovid #MECFS symptom data into tracking app Visible.

👉 Crashes more likely during menstruation

👉 Crashes less common in ppl taking combined hormonal contraception

1/

#ChronicIllness #MedSky #ReproSky #IDSky

www.medrxiv.org/content/10.1...

Intrahepatic levels of microbiome-derived hippurate associates with improved metabolic dysfunction-associated steatotic liver disease Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterised by lipid accumulation in the liver and is often associated with obes…

Could the gut #microbiome protect against fatty liver disease? 🦠🍎

New research published in Molecular Metabolism & led by MDR's @marcedumas.bsky.social, shows hippurate, a microbial metabolite, helps reduce fat in the liver and regulate glucose. ⬇️

www.sciencedirect.com/science/arti...