UCL Dept of Aging, Rheumatology & Regenerative Medicine

Hemophagocytic Lymphohistiocytosis in Pregnancy: A Systematic Review of Case Reports and Case Series Aims Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening syndrome caused by excessive immune activation, leading to severe inflammation and multi-organ failure. While adult-onset HL...

New systematic review of pregnancy associated HLH
- 104 pregnancies
- commonest cause infections (EBV, CMV, HSV, parvo)
- followed by SLE, stills, lymphoma
- 4/14 tested has positive genetics
- 40% no known cause
onlinelibrary.wiley.com/doi/epdf/10....
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@thelisterinstitute.bsky.social - a great experience talking about our group’s research for the Lister blog. Working with children and young people is a privilege and I’d ask every translational scientist to ask the question… is your research age inclusive? ✨ lister-institute.org.uk/the-bigger-p...

Simple blood test offers new hope to lupus patients Up to 69,000 people in the UK have lupus, a chronic autoimmune condition

www.independent.co.uk/news/health/...

www.nihr.ac.uk/story/strati... a big thank you to the lupus specialists and their patients who made this research possible

So fantastic to see this work out @shipam.bsky.social, with Prof Michael Ehrenstein and Dr Dan McCluskey. This new departmental paper shows the utility of anti-dsDNA IgA2 and IgA2+ B cells as a biomarker for response to Belimumab in SLE. Read in @cp-cell.bsky.social journal - Cell Reports Medicine.

Writing a paper?

Join us tomorrow at 12:00 BST for a free webinar with OUP Publisher Rachel Moriarty & our very own EIC Simon Milling.

Essential tips on journal selection, peer review, and maximising impact.

Register here: https://bit.ly/44ARC1p

Very happy to share our latest preprint, where we address the relationship between systemic and gut IgA. See link below and details in 🧵. Huge thanks to everyone involved!

www.biorxiv.org/content/10.1...

PhD Research Fellowship in Immunology A 3-year PhD fellowship is available at the Department of Immunology, Oslo University Hospital. The position will be located in the lab of Dr. Rasmus Iversen and will be available from August 2025. Th...

I am looking for a PhD candidate to join my lab in Oslo! We are trying to understand the role of antigen-specific B cells in autoimmunity. See details and apply here 👇
2411.webcruiter.no/Main2/Recrui...

Congrats @heather--cross.bsky.social, taking the conference circuit by storm!

Review Article Juvenile Idiopathic Arthritis Christy I. Sandborg, M.D., Grant S. Schulert, M.D., Ph.D., and Yukiko Kimura, M.D. Photos showing the common clinical manifestations of juvenile idiopathic arthritis

A new review discusses the features of oligoarticular, polyarticular, systemic, and psoriatic JIA and enthesitis-related arthritis, as well as advances in treatment for these conditions. Read the full review: nej.md/4lJMkq4

#MedSky #PedSky

Our lab day out last week in west London by the River… Grateful we are growing due to support from @medresfdn.bsky.social #moorfieldeyecharity & @thelisterinstitute.bsky.social. A new generation of leaders in childhood autoimmunity in the making! @dianaematei.bsky.social @arrdept-ucldom.bsky.social

Can’t wait!

Thank you @iuis-online.bsky.social and @britsocimm.bsky.social!

@arrdept-ucldom.bsky.social
@uclmedsci.bsky.social
@uclpress.bsky.social

First of its kind study for children with arthritis reveals possible new disease targets Researchers have been able to see what happens in the inflamed joints of children with arthritis, giving insight into why treatments affect children differently.

First of its kind study for children with arthritis reveals possible new disease targets.

Researchers have been able to see what happens in the inflamed joints of children with arthritis, giving insight into why treatments affect children differently. Read: www.ucl.ac.uk/news/2025/ju...

Synovial tissue atlas in juvenile idiopathic arthritis reveals pathogenic niches associated with disease severity An atlas of the cellular and molecular landscape of the juvenile idiopathic arthritis synovium defines tissue niches associated with disease severity.

So great to see ARR collaborators in science translational medicine this morning - www.science.org/doi/10.1126/.... An important movement for #Paed Rheum research and tissue biology #immunosky @dr-chrissyb.bsky.social #Wedderburngroup #Croftgroup #ChrisMahony @science.org

#JIA research on the front cover! Congratulations to @dr-chrissyb.bsky.social, Chris Mahony, Prof Wedderburn & CI of MAPJAGProf Croft. This @science.org translational medicine study shows the power of studying tissue biology in childhood arthritis. Read it now!

www.science.org/doi/10.1126/...

Congrats @mcdonnelllab.bsky.social on this amazing paper. Resharing in case for those who haven’t had the chance to read it yet!

📣Call out to #bcell enthusiasts!

#EFIS IL-Study Group European B cell Network is happy to invite you to their Satellite Symposium at the #IUIS2025.

Don't miss the opportunity to listen to brilliant speakers highlighting the recent advances in #Bcellbiology.

@yefis-immunology.bsky.social

Exciting new position in #arrdept alumni @madhvimenon.bsky.social lab 🧬

Kupffer cell programming by maternal obesity triggers fatty liver disease Nature - In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.

We are SO EXCITED to share our story @nature.com:
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b

How can policy support autistic people’s access to employment? There is a gap between those who want to work and those who can access employment, says Professor Anna Remington, who gave evidence to the House of Lords on supporting employment for autistic people.

How can policy support autistic people’s access to employment?

@annaremington.bsky.social (@craeioe.bsky.social) gave evidence to the House of Lords in May emphasising the importance of including autistic people in decision-making on employment and support priorities.
www.ucl.ac.uk/ioe/news/202...

This was a fantastic celebration yesterday - thanks to the @thelisterinstitute.bsky.social and @arrdept-ucldom.bsky.social and the wider division of Medicine for all their support 😊

So fabulous to see this paper out! Prof Lucy Wedderburn is a close collaborator of many researchers in our dept and this paper makes an important contribution to continued efforts to understand better ways to predict treatment response in patients with autoimmune conditions 🧬 read more below 👇

Thank you so much! 😁 #EULAR2025 was an amazing first conference talk and I am so pleased and grateful to have been featured in the highlights as well!

Our department has had a stellar week at #EULAR. Special congrats to @heather--cross.bsky.social for not only having her first conference talk of her PhD but also having presented as a translational immunology highlight ✨

Prof Isenberg’s @arrdept-ucldom.bsky.social dinner 🍽️

Congratulation Heather 👏🏽👏🏾👏🏿

@heather--cross.bsky.social has also made the #EULAR2025 congress highlights for basic and translational science!👏
Selected/presented by Dr Rachel Knevel
Congratulations Heather! On behalf of myself and @ciurtinlab.bsky.social this is so well deserved for your hard work!
@arrdept-ucldom.bsky.social

@heather--cross.bsky.social presenting very soon on sex hormone/chromosome driven mechanisms of cSLE risk #EULAR2025! Join us in room A1 to hear some super interesting research! 🧬 🦠
@ciurtinlab.bsky.social
@arrdept-ucldom.bsky.social
Fantastic session with Jean-Charles Guery and Amy Roberts too 👇

Review @eurjimmunol.bsky.social
Meningeal Immunity: Anatomy, Function, and Neonatal Unique Features
onlinelibrary.wiley.com/doi/10.1002/...

1 in 10 people with #lupus are men — but their stories are often overlooked. This #MensHealthMonth, we’re raising awareness about how lupus impacts men differently. From more severe complications to delayed diagnoses.

🔗 Learn more about lupus and men: buff.ly/QB1lL9S