UCL Dept of Aging, Rheumatology & Regenerative Medicine

In vivo CAR-T cell engineering in refractory SLE - Nature Reviews Rheumatology Infused lipid nanoparticles were successfully used to generate CAR-T cells in patients with refractory systemic lupus erythematosus, achieving B cell depletion.

www.nature.com/articles/s41...

Original article📖→ www.nejm.org/doi/10.1056/...
“In vivo CD19 CAR T-cell therapy for refractory systemic lupus erythematosus.” N. Engl. J. Med.

#SLE #lupus #CART

@uclnews.bsky.social

What is lupus, the condition Selena Gomez is diagnosed with? The autoimmune disease lupus, which affects mainly women, can have wide-ranging impacts on health and quality of life.

Have been a big fan of the @theconversation.com for a while so was a real please to write this article with them. Thank you to @medresfdn.bsky.social for suggesting me and please do have a read 👇

theconversation.com/what-is-lupu...

Fantastic pictures @georgearobinson.bsky.social and congratulations again @ciurtinlab.bsky.social

Congratulations 🥳 to Prof Ciurtin @ciurtinlab.bsky.social who will deliver the 2025 Lady Estelle Wolfson Lecture in Translational Medicine at the Royal College of Physicians today! Coziana will focus on improving risk stratification and management of cardiovascular risk in young people with lupus.

Great session at #PReS2025 discussing challenges in the transition of care in rheumatology. Session dedicated to the memory #Dr.JanetMcDonagh in recognition of her amazing contribution to the field. @ciurtinlab.bsky.social @arrdept-ucldom.bsky.social @versusarthritis.bsky.social #BANNAR; #YourRheum

I am so excited to be contributing to the upcoming ‘Medicine at the Crick Event’ @crick.ac.uk… organised by Prof Vinuesa and Prof Lee.. come and join us for what will be a fantastic discussion… @arrdept-ucldom.bsky.social

www.crick.ac.uk/whats-on/med...

@mikeehrenstein.bsky.social @shipam.bsky.social… add anyone we’ve missed!

@georgearobinson.bsky.social @bcellsrosser.bsky.social @ciurtinlab.bsky.social @dianaematei.bsky.social @heather--cross.bsky.social @junjie-peng.bsky.social @bethangoulden.bsky.social @oliviabracken.bsky.social @jury-lab.bsky.social @mcdonnelllab.bsky.social

We now have over 600 followers! Hello everyone from our new UCL department! Give some of our members a follow when you have a chance (we’ll post the in the thread below!) and stay tuned for our research updates 🧬 🎇 😃

Nailed it!
@heather--cross.bsky.social
@ciurtinlab.bsky.social
@arrdept-ucldom.bsky.social

Exciting week ahead in Helsinki for #PReS2025! 🇫🇮
First up it’s the young investors meeting!
Fantastic science and a privilege to be on the organising committee of #PReSEMERGE
An @arrdept-ucldom.bsky.social takeover later for the #cSLE session with @junjie-peng.bsky.social @heather--cross.bsky.social

Congrats Nina!

Great to see our close collaborator’s paper out now in Annals of the Rheumatic Diseases @bmj.com. Read the press release 👇

Loved every minute, thank you #IUIS2025 and congratulations to everyone on the RS programme!
@iuis-online.bsky.social
@arrdept-ucldom.bsky.social

Fantastic week down in Cornwall with the family and my boy. Now off to Vienna for #IUIS2025! Excited to meet this amazing international group of early career researchers later today and can’t wait to present tomorrow.
See you there!
@iuis-online.bsky.social
@arrdept-ucldom.bsky.social

Thanks @dianaematei.bsky.social - I loved writing this with Prof Wedderburn in @natrevrheum.nature.com on the back of our new departmental launch @arrdept-ucldom.bsky.social ✨

🌟 Got exciting immunology research to share? There’s still time to submit your abstract for BSI Congress! #BSI25

Present your findings to 1,500+ experts, grow your network, and spark new collaborations that can boost your career.

Submit by 3 Sept ➡️ https://bit.ly/3UfF6i5

Hematopoietic loss of Y chromosome leads to immune inhibitory receptor up-regulation, impairing senescent cell clearance
www.science.org/doi/10.1126/...

Hemophagocytic Lymphohistiocytosis in Pregnancy: A Systematic Review of Case Reports and Case Series Aims Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening syndrome caused by excessive immune activation, leading to severe inflammation and multi-organ failure. While adult-onset HL...

New systematic review of pregnancy associated HLH
- 104 pregnancies
- commonest cause infections (EBV, CMV, HSV, parvo)
- followed by SLE, stills, lymphoma
- 4/14 tested has positive genetics
- 40% no known cause
onlinelibrary.wiley.com/doi/epdf/10....
1/6

@thelisterinstitute.bsky.social - a great experience talking about our group’s research for the Lister blog. Working with children and young people is a privilege and I’d ask every translational scientist to ask the question… is your research age inclusive? ✨ lister-institute.org.uk/the-bigger-p...

Simple blood test offers new hope to lupus patients Up to 69,000 people in the UK have lupus, a chronic autoimmune condition

www.independent.co.uk/news/health/...

www.nihr.ac.uk/story/strati... a big thank you to the lupus specialists and their patients who made this research possible

So fantastic to see this work out @shipam.bsky.social, with Prof Michael Ehrenstein and Dr Dan McCluskey. This new departmental paper shows the utility of anti-dsDNA IgA2 and IgA2+ B cells as a biomarker for response to Belimumab in SLE. Read in @cp-cell.bsky.social journal - Cell Reports Medicine.

Writing a paper?

Join us tomorrow at 12:00 BST for a free webinar with OUP Publisher Rachel Moriarty & our very own EIC Simon Milling.

Essential tips on journal selection, peer review, and maximising impact.

Register here: https://bit.ly/44ARC1p

Very happy to share our latest preprint, where we address the relationship between systemic and gut IgA. See link below and details in 🧵. Huge thanks to everyone involved!

www.biorxiv.org/content/10.1...

PhD Research Fellowship in Immunology A 3-year PhD fellowship is available at the Department of Immunology, Oslo University Hospital. The position will be located in the lab of Dr. Rasmus Iversen and will be available from August 2025. Th...

I am looking for a PhD candidate to join my lab in Oslo! We are trying to understand the role of antigen-specific B cells in autoimmunity. See details and apply here 👇
2411.webcruiter.no/Main2/Recrui...

Congrats @heather--cross.bsky.social, taking the conference circuit by storm!

Review Article Juvenile Idiopathic Arthritis Christy I. Sandborg, M.D., Grant S. Schulert, M.D., Ph.D., and Yukiko Kimura, M.D. Photos showing the common clinical manifestations of juvenile idiopathic arthritis

A new review discusses the features of oligoarticular, polyarticular, systemic, and psoriatic JIA and enthesitis-related arthritis, as well as advances in treatment for these conditions. Read the full review: nej.md/4lJMkq4

#MedSky #PedSky

Our lab day out last week in west London by the River… Grateful we are growing due to support from @medresfdn.bsky.social #moorfieldeyecharity & @thelisterinstitute.bsky.social. A new generation of leaders in childhood autoimmunity in the making! @dianaematei.bsky.social @arrdept-ucldom.bsky.social