Noam Shemesh

Ramping up cortical activity in early life sparks autism-like behaviors in mice The findings add fuel to the long-running debate over how an imbalance in excitatory and inhibitory signaling contributes to the autism.

Great coverage by @thetransmissions.bsky.social of our latest preprint: adding new evidence (and a hint of controversy 🙂) to the E/I imbalance debate in autism
👇👇
www.thetransmitter.org/spectrum/ram...

Unlike the heart attack of getting a “Decision” email, it’s such a good feeling to get a “Your review is ready” email from qed :)

BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

Tried this on a very technical fMRI manuscript with neuroscience applications. It warned me that neuroses outside its core expertise, but then proceeded to present an amazing analysis of the claims in the paper. Vastly superior to ChatGPT for example. I am impressed!

The things we can do @westernu.ca thanks to platform support grant funding from @braincanada.bsky.social And #NFRF

Authors retract Science paper on controversial fMRI method Several MRI artifacts contribute to the neuronal activity signal picked up by the method, according to a preprint the authors posted this month.

Even though the controversial DIANA method didn’t pan out, neuroimaging researchers still hold out hope to one day measure neuronal activity using fMRI.

By @callimcflurry.bsky.social

www.thetransmitter.org/retraction/a...

New paper in Imaging Neuroscience by Roza G. Bayrak, Catie Chang, et al:

DeepPhysioRecon: Tracing peripheral physiology in low frequency fMRI dynamics

doi.org/10.1162/IMAG...

A non-invasive approach to awake mouse fMRI compatible with multi-modal techniques Abstract. Mouse functional magnetic resonance imaging (fMRI) studies contribute significantly to basic fundamental and translational neuroscience research. Performing fMRI in awake mice could facilita...

A new open source nonsurgical head restraint for awake mouse fMRI from our lab led by Sam Laxer. TL;DR Scanning about 25% longer than with a surgically implanted head post, combined with some training gives good results. Happy mice = happy rsfmri networks. direct.mit.edu/imag/article...

Authors retract Science paper on controversial fMRI method Several MRI artifacts contribute to the neuronal activity signal picked up by the method, according to a preprint the authors posted this month.

Science is self correcting. Finally!

Authors retract Science paper on controversial fMRI method Several MRI artifacts contribute to the neuronal activity signal picked up by the method, according to a preprint the authors posted this month.

A method for capturing neuronal activity using fMRI excited the neuroimaging field but couldn’t be replicated. Today, the authors of the original paper retracted their work.

By @callimcflurry.bsky.social

#neuroskyence

www.thetransmitter.org/retraction/a...

Authors retract Science paper on controversial fMRI method Several MRI artifacts contribute to the neuronal activity signal picked up by the method, according to a preprint the authors posted this month.

An important retraction of the DIANA paper. Scientific progress is often made by correcting prior efforts, and here the community played its part efficiently. While this particular form of mapping neural activity was unsuccessful, the search continues!

www.thetransmitter.org/retraction/a...

New paper in Imaging Neuroscience by Marie E. Galteau, Joanes Grandjean, et al:

Activation mapping in multi-center retrospective rat sensory-evoked functional MRI datasets using a unified pipeline

doi.org/10.1162/IMAG...

Functional MRI reveals subcortical auditory push-pull interactions requiring intercollicular integrity Abstract. The role of subcortical structures in binaural integration is of great interest for auditory processing. The inferior colliculus (IC) is the main auditory midbrain center where ascending and...

direct.mit.edu/imag/article...

NEW PAPER!
After many years in the making... we present evidence that BOLD-fMRI can detect push-pull interactions in subcortical areas. Congrats to Frederico Severo and Mafalda Valente!

More fields need to do this.

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

Another new paper from the Lab, with a multimodal fMRI / CBF / cFOS approach in an animal model of Parkinson's Disease!

Congrats @ruxandalungu.bsky.social @ciscaff.bsky.social, Sara Monteiro and our great collaborator Tiago Monteiro!

journals.sagepub.com/doi/10.1177/...

Evidence for a push-pull interaction between superior colliculi in monocular dynamic vision mode - Communications Biology A SC push-pull interaction during the dynamic vision mode, revealed with functional MRI and brain lesions, challenges the notion that intertectal connections solely serve as reciprocal inhibitory mech...

🧠👁️A SC push-pull interaction during the dynamic vision mode, revealed with fMRI and brain lesions, challenges the notion that intertectal connections solely serve as reciprocal inhibitory mechanisms for avoiding visual blur during saccades. @shemesh-lab.bsky.social

doi.org/10.1038/s420...

Evidence for a push-pull interaction between superior colliculi in monocular dynamic vision mode - Communications Biology A SC push-pull interaction during the dynamic vision mode, revealed with functional MRI and brain lesions, challenges the notion that intertectal connections solely serve as reciprocal inhibitory mech...

new paper from the Lab, harnessing fMRI and lesions to reveal some interesting "push-pull" interactions in Superior Colliculus! Check it out here
www.nature.com/articles/s42...

Congrats Mafalda!

Neuroplasticity-driven timing modulations revealed by ultrafast functional magnetic resonance imaging Detecting neuroplasticity in global brain circuits in vivo is key for understanding myriad processes such as memory, learning, and recovery from injur…

Nice work. Note also these:

www.nature.com/articles/s41...

www.sciencedirect.com/science/arti...

1/ Six years in the making! Our preprint on SORDINO fMRI is out. We're sharing the raw data and sequence to facilitate brain-wide mapping in awake, behaving rodents. If this could be useful to your colleagues and friends, please help spread the word!
www.biorxiv.org/content/10.1...

AMAZING

😱
In-vivo? How long was the scan time and if UTE where is the contrast coming from then?

Rosette Spectroscopic Imaging for Whole‐Brain Slab Metabolite Mapping at 7T: Acceleration Potential and Reproducibility 2D-/3D- whole-brain slab non-lipid-suppression ultra-short-TE 1H-MRSI acquisition schemes were developed using the rosette trajectory at 7T. This method showed excellent intra-session reproducibility...

onlinelibrary.wiley.com/doi/full/10....

AMAZING opportunity, don't miss it!

CONGRATS and well deserved! Super happy that we will have such a great person in critical ESMI positions in the following years!

Professor Tim Witney elected Vice President of ESMI Professor Tim Witney, Wellcome Trust Senior Research Fellow and Professor of Molecular Imaging at the School of Biomedical Engineering & Imaging Sciences, has been elected the Vice President of the Eu...

It’s the honour of a lifetime to be elected as ESMI's President-elect. Thank you for your faith in me. I will work hard to promote the values of the Society to a broad audience and be a strong advocate for the discoveries you have made in molecular imaging. 🙏🏻

www.kcl.ac.uk/news/profess...

Layer connective fields from ultrafast resting-state fMRI differentiate feedforward from feedback signaling Deciphering the directionality of information flow in cortical circuits is essential for understanding brain dynamics, learning, and neuroplasticity after injury. However, current non-invasive methods...

check out our new preprint! Together with Joana Carvalho and Koen Hak (and co-authors) we developed an ultrafast fMRI with layer resolution, and show how feedback/feedforward signals can be mapped from a layer connective field model
www.biorxiv.org/content/10.1...

MORE in a few weeks!

🔍 New must-see resource! 🧠
--> Reproducible Brain Charts – an open-data tool for mapping brain development & mental health

www.biorxiv.org/content/10.1...

👏 Kudos to @ted-satterthwaite.bsky.social and Michael Milham @childmindinstitute.bsky.social for leading this effort!

Feasibility and comparison of 3D modified rosette ultra-short echo time (PETALUTE) with conventional weighted acquisition in 31P-MRSI - Scientific Reports Scientific Reports - Feasibility and comparison of 3D modified rosette ultra-short echo time (PETALUTE) with conventional weighted acquisition in 31P-MRSI

Consistent with earlier publications, the #PETALUTE sequence features enhanced incoherent sampling for compressed sensing (CS). Through simulation, phantom, and in vivo comparisons, results demonstrate PETALUTE's competitive performance against conventional nuclei #MRSI and #MRI methods.