Katrina Collins || Pathologist

Immunohistochemistry New Instrument Validations: Why Your Validation Plan Matters journals.lww.com/appliedimmun...

🆕 New publication alert 🚨
PC-RPLND from patients with TGCTs: key morphologic variants, diagnostic pitfalls, and clinical impact—read & share!

🔗 www.sciencedirect.com/science/arti...

#pathtwitter #pathX #gupath #TGCT #IUPathology #indianapath @iupathology

Exciting news! 🎉 Fiona Maclean joins us as the International Councillor for Australia. Welcome, Fiona — we’re delighted to have your experience and leadership representing Australia and supporting our members across the region! 🇦🇺

Which matters more: talent or luck? In games like poker, luck is clear. In life, it shows up as unexpected chances or being in the right place at the right time. #readinglist #goodread

🔗 www.worldscientific.com/doi/10.1142/...

Investigating Biomarkers in Primary Tumors and Lymph Node... : Applied Immunohistochemistry & Molecular Morphology tases. A total of 60 TSCC biopsy samples, 20 primary metastatic, 20 lymph node metastatic, and 20 nonmetastatic, were immunohistochemically stained to analyze MCM2, CD44, and E-cadherin expression. Ex...

Investigating Biomarkers in Primary Tumors and Lymph Node Metastases in Tongue Squamous Cell Carcinoma: An Immunohistochemical Perspective journals.lww.com/appliedimmun...

Distinct levels of DDIT3 Amplification in Dedifferentiated... : Applied Immunohistochemistry & Molecular Morphology diagnostic tool for accurate diagnosis. While DDIT3 rearrangement is a known characteristic of myxoid LPS, its amplification in DDLPS has not been extensively studied. To investigate this, we evaluate...

Distinct levels of DDIT3 Amplification in Dedifferentiated Liposarcoma Developing After DDIT3 Rearrangement in Myxoid Liposarcoma journals.lww.com/appliedimmun...

STAT6 Can Be Used in the Diagnosis of Hodgkin Lymphoma;... : Applied Immunohistochemistry & Molecular Morphology the STAT6 (EP325) immunostain, diagnosing Hodgkin lymphoma, its staining frequency, immunolocalization, and its relationship with EBV. Sixty-eight patients representing each Hodgkin lymphoma subtype w...

STAT6 Can Be Used in the Diagnosis of Hodgkin Lymphoma; There Are Differences in Expression Among Subtypes journals.lww.com/appliedimmun...

Immunohistochemical Study on Programmed Death Ligand 1... : Applied Immunohistochemistry & Molecular Morphology in order to maximize its therapeutic role in different clinicopathological settings. This study aimed to evaluate PD-L1 immunohistochemical expression in both tumor cells (TCs) and tumor-infiltrating ...

Immunohistochemical Study on Programmed Death Ligand 1 (PD-L1) in Breast Carcinoma and Its Correlation With the Clinicopathological Parameters
journals.lww.com/appliedimmun...

🚀 Join us for the launch of our Journal Club Webinar Series!
📚 Articles #openaccess starting July 28
👨🏻‍💻 Don't miss this opportunity to explore new research with us! #AIMMjc

Register 👉🏻 tinyurl.com/ycxeye84

🔗 journals.lww.com/appliedimmun...
🔗 journals.lww.com/appliedimmun...

EWSR1::NFATC2 Rearranged Sarcoma: Distinct... : Applied Immunohistochemistry & Molecular Morphology omas with EWSR1–non-ETS fusions, particularly EWSR1::NFATC2 fusion. We identified 5 cases of EWSR1::NFATC2 fusion sarcomas. There was male preponderance and all the patients had a history of trivial t...

EWSR1::NFATC2 Rearranged Sarcoma Distinct Clinicopathological Features From a Series of 5 Rare Cases journals.lww.com/appliedimmun...

Join us for the 3rd Annual Euro Grawitz Dinner in Vienna!
📅 Sept 10, 2025 | 5:30 PM
🍽️ Zum weißen Rauchfangkehrer

Reserve by Sept 3: www.eventbrite.com/e/1527667858...

Special thanks to our local organizers making this event possible: Prof. Eva Compérat and Miss Amy Rattan

Colleagues: the ISUP @intsocuropath.bsky.social website has been down recently while a new website was being built.

New website is now available isupweb.net and in progress being expanded with additional features!

An email to members was sent July 18 via mailchimp.

📚 #readinglist #mustreads
Perfect for those starting their careers, Fragale strikes a balance between smart and approachability. Her advice offers actionable tips that help leverage strengths to own your space. @alisonfragale

📖 Have you read it? If not, add it to your list!!

#slidearchiveseries urothelial carcinoma in situ colonizing prostatic urethra #gupath

Check out our Current Issue!!

Figure from "Telomerase Immunocytochemistry in Lymphocytes From Chronic Lymphocytic Leukemia” by Sučić, et al.

🔗 Read the full article here: journals.lww.com/appliedimmun...

#slidearchiveseries seminal vesicle invasion #gupath #prostatecancer

1️⃣ spreading along the ejaculatory duct
2️⃣ direct invasion at the base of the prostate or extension into peri-SV soft tissue and then into the wall of the SV
3️⃣ discontinuous metastases (rare)

🔗 doi.org/10.1038/modp...

#slidearchiveseries history of nephrectomy for renal cell carcinoma, received immunotherapy with complete response, later developed upper GI bleeding from metastases to the proximal jejunum #gupath #gipath

The Expression and Clinical Features of 8... : Applied Immunohistochemistry & Molecular Morphology valuable insights into the diagnosis and management of adrenal tumors. We retrospectively analyzed cases of patients treated in the urology department of our hospital from April 2017 to May 2022, focu...

The Expression and Clinical Features of 8 Immunohistochemistry Markers in Adrenal Cortical Adenomas and Pheochromocytomas journals.lww.com/appliedimmun...

Just published! Check out this latest article by @iamshreeya.bsky.social

🔬 Molecular subtyping of bladder cancer is essential—but not always feasible in low-resource settings
🧪 IHC markers GATA3, KRT20, KRT14, KRT5 used to stratify UCs
⚠️ Dual-negative had poorest survival (25%), luminal best (80%)

Can you spot treatment effects in prostate cancer and distinguish secondary tumors involving the prostate? This case-based CME session covers ADT/radiation changes, rare variants, and more.

Check out this session—plan on joining us at #CAP25!

🔗 events.cap.org/event/cap25/...

#slidearchiveseries chromophobe renal cell carcinoma #gupath #pathsky #pathoutpic

✅ solid sheet-like architecture
✅ plant-like cell borders (vegetable cells)
✅ irregular, wrinkled nuclei (raisinoid)
✅ binucleation and perinuclear halos
🎨 CK7, CD117, Hale colloidal iron

#macrovsmicro total nephrectomy, tan to red, nodular, heterogeneous, well-delineated, focally hemorrhagic/necrotic mass #gupath #pathsky #pathoutpic #kidneytumor

Our pathology team is walking to fight kidney disease and support the life-changing work of the @nkf-professionals.bsky.social! On June 21, we walk for all who’ve been impacted by this chronic illness. Join us or donate to help make a difference: www.kidneywalk.org/indy/IUPatho...
#kidneywalk

Liver immunostaining for this #FluorescenceFriday

Just published! Check out this latest article 👉🏻 HER2 amplification is rare (1.7%) in low-grade, tubule-forming breast cancers with 2+ HER2 IHC; findings suggest ISH may be unnecessary in this subset #breastpath #IHCpath #pathsky

Expression of Hippo Pathway Molecules in Distal Bile Duct... : Applied Immunohistochemistry & Molecular Morphology ) are primary Hippo pathway components. We evaluated LATS1/2, YAP, and TEAD4 expression and their correlation with clinicopathological behavior and prognostic significance in 67 distal bile duct cance...

Expression of Hippo Pathway Molecules in Distal Bile Duct Cancer journals.lww.com/appliedimmun...

Just published! Check out this latest article!
🔵 PD-L1 expression showed high concordance between cores and full slides.
🔵 CD8+ T cell and CD68+ macrophage densities varied; cores underrepresented immune infiltrates.
@fabiotavora.bsky.social #IHCpath #lungcancer

Evaluation of Diagnostic Accuracy of Immunohistochemical... : Applied Immunohistochemistry & Molecular Morphology ents with mucinous adenocarcinomas—31 lower gastrointestinal (GI), 28 ovarian, and 12 cases of pseudomyxoma peritonei. Immunohistochemistry for SATB2 and villin was performed on ovarian and GI tumor s...

Evaluation of Diagnostic Accuracy of Immunohistochemical Markers of SATB2 and Villin in Differential Diagnosis of Ovarian and Gastrointestinal Mucinous Carcinoma journals.lww.com/appliedimmun...

The Value of Routine Reflex In Situ Hybridization Testing... : Applied Immunohistochemistry & Molecular Morphology emistry (IHC). While this recommendation mainly addresses aggressive tumor types such as micropapillary carcinoma, it is applied to low-grade, tubule-forming IBCs unlikely to show HER2 amplification. ...

The Value of Routine Reflex In Situ Hybridization Testing in Low-grade Tubule-forming Invasive Breast Cancers With Equivocal HER2 Immunohistochemistry - A Reappraisal of the ASCO/CAP Guidelines journals.lww.com/appliedimmun...