New preprint: evolution of cross-resistance between two cancer drugs inferred from lineage barcoding data from single drug exposures. Removes need for complex combinatorial exposure experiments. Another tour de force from brilliant Freddie Whiting @icr.ac.uk www.biorxiv.org/content/10.6...
Your #gut doesn’t just digest food – it affects immunity, #metabolism + even mental health.
@imperialcollegeldn.bsky.social's Centre for Intestinal Systems aims to make gut research more human-relevant + more useful for patients.
👇 blogs.imperial.ac.uk/imperial-med... @imperialmdr.bsky.social
A big thank you to @bowelcanceruk.bsky.social and all their wonderful supporters for funding our research that aims to develop a blood test to predict bowel #cancer risk for people with inflammatory bowel disease #IBD. www.bowelcanceruk.org.uk/research/our... @icr.ac.uk
1/17 🧵
🙌Thrilled to share our first hard-core immunology paper out today in Nature Genetics! 👇
➡️We unravel how TGFβ suppresses the innate and adaptive immune system in microsatellite stable colorectal cancer (MSS CRC).
Very proud of the team and efforts behind it.
www.nature.com/articles/s41...
Excited to share our new paper: ‘Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell–Mediated Immunomodulation’ led by Callum Nattress in collab. with Jonathan Fisher lab (1/13)
aacrjournals.org/cancerres/ar...
Do you have:
📌 Blood in your poo?
📌 Abdominal pain that won’t go away?
📌 Diarrhoea that can’t wait?
If you have experienced any of these symptoms, you may have a problem with your bowel health.
FREE testing kits are available for EX postcode residents aged 16–49 ➡️ bit.ly/IBDKit
Our results support universal and paired somatic and germline multi-gene panels for all EOCRC patients, regardless of MMR status or family history
onlinelibrary.wiley.com/doi/10.1002/...
Honoured to to be part of this Future of Hepatology session at @easlnews.bsky.social #EASL2025, discussing the promise of #microbiome related therapies in #PSC #cholestatic liver disease - where have we come since the original #FMT #PSC pilot study by @DrAllegrettiIBD? doi.org/10.14309/ajg...
📘 What could nephrology look like in 2050?
This article for the Future Healthcare Journal was fun to write! — here’s a 🧵 of what might be coming next in kidney care:
shorturl.at/A18zK
This is brilliant - super clear and a must-have resource for who (and who not) to test in the clinic. Highly recommend!
The National Genomics Education Programme have launched #GeNotes collection specifically for #Genomics cases in your practice @britsocgastro.bsky.social www.bsg.org.uk/news/new-nat...
1. You feel powerless? Don’t know what you can do to resist the rise of fascism?
Here is an answer: Good Things.
Fascism inflicts pain and harm as a matter of doctrine.
Kindness, care and conviviality defend us from it.
The more we build community, the less it can take root.
🧵
A great first day at the #BSG #GutMicrobiome event, covering everything from early life @halllab.bsky.social, to #liver @debbieshawcross.bsky.social, to #cancer @jameskinross.bsky.social, and culminating in a tour de force on #IBD and the #microbiome in clinical practice from Prof Harry Sokol
🚨 We're hiring! 🚨
The Chain Florey Transition-To-Independence Fellowship Scheme is open for applications! We have 3 positions available: 2 generic and 1 cardiology specific.
If you're a clinician scientist this is your chance to join the Chain Florey program!
Don't miss out—apply now! 💼👇
Wondering if your patient with small bowel inflammation has Crohn's vs intestinal TB?
Summarize all of your data with this website to get a probability. Add new (projected) test results to see how new results would change the estimate. #IBD
www.pathology.med.umich.edu/shiny/tbcroh...
Really enjoyed working on this review for Frontline Gastroenterology. How do anti-IL23 therapies work? What’s the evidence for their use in IBD? And is there any guidance on how we should position them in the treatment landscape?
fg.bmj.com/content/earl...
Pleased that #FARGO - a randomised, multicentre, placebo-controlled phase IIa trial of #FMT to treat #PSC - is running and recruiting. Have a look at the protocol paper out now in #BMJOpen: doi.org/10.1136/bmjo... @pscsupport.bsky.social @cholestasisdoc.bsky.social
Intestinal E. coli-produced yersiniabactin promotes profibrotic macrophages in Crohn’s disease
www.cell.com/cell-host-mi...
Check out the @mrc-lms.bsky.social Chain Florey clinician scientist programme for those interested in mechanistic discovery science and experimental medicine - 12-month predoctoral fellowships currently up for grabs!
lms.mrc.ac.uk/work-and-stu...
What is inflammatory bowel disease (IBD) and how can a gene desert help us to understand its causes and potential future treatments? 🧬🧪
Hear the Crick's James Lee sharing his insights in the first in our series of Crick Crash Courses. www.youtube.com/watch?v=bcc8...
New work on #tuft cells, rare guardians of our #gut against invaders. How they work is not known. We show that intestinal tuft types 1&2 are sequentially expressed phenotypes during differentiation. And…we can now generate mature immune-related tuft-2’s in #organoids for more 🔬🧫🧬🔥
shorturl.at/EImjA
We know everything about IL-33 already, right?
No! In fact we know very little about IL-33 in the colonic epithelium
Our recent paper finds IL-33 is highly enriched in colonic stem cells suggesting an immunoregulatory role for this niche in injury🧵
www.mucosalimmunology.org/article/S193...
#LocationLocationLocation! Baghdadi, Kim &co show @science.org that intestinal stem cells #ISCs located at the bottom of the crypts sense a more rigid environment & activate PIEZO to tune their proliferation/differentiation maintaining gut physiology! doi.org/10.1126/scie...
#immunosky
The power of spatial information! ILC2s specifically in the middle of the colon express microbiota-induced genes that are important for the structural adaptation of this part of the gut. Loads of spatial data across different states (homeostasis vs inflammation) for the community.
👨🔬🎉Kicking off my bluesky presence by posting our lab's achievement! Our lab's first study is now out in Cell ! We show that IFN-λ induces ZBP1/CASP-8/GSDMC-dependent pyroptosis in gut epithelial cells impairing tissue repair post-colitis.#IBD #Immunology 🧵https://authors.elsevier.com/a/1k2OAL7PXqSL5
Happy to share the work from my residency at #Charite available as pre-proof version in #Gastroenterology.
We identify Ki67+ memory CD4+ T cells as robust blood-based predictor for non-response to #vedolizumab (anti-integrin a4b7) in #IBD patients before therapy.
doi.org/10.1053/j.ga...
Very proud of this one. Sarah Hamoudi, PhD student in the lab, developed autologous cocultures between mucosal T cells and epithelial organoids from control or from patients with Crohn's disease.
www.biorxiv.org/content/10.1...
