Greg Sebepos-Rogers

Excited to share our new paper: ‘Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell–Mediated Immunomodulation’ led by Callum Nattress in collab. with Jonathan Fisher lab (1/13)
aacrjournals.org/cancerres/ar...

Do you have:

📌 Blood in your poo?
📌 Abdominal pain that won’t go away?
📌 Diarrhoea that can’t wait?

If you have experienced any of these symptoms, you may have a problem with your bowel health.

FREE testing kits are available for EX postcode residents aged 16–49 ➡️ bit.ly/IBDKit

Our results support universal and paired somatic and germline multi-gene panels for all EOCRC patients, regardless of MMR status or family history

onlinelibrary.wiley.com/doi/10.1002/...

Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids The vasculature and mesenchyme exhibit distinct organ-specific characteristics adapted to local physiological needs, shaped by microenvironmental and …

www.sciencedirect.com/science/arti...

Honoured to to be part of this Future of Hepatology session at @easlnews.bsky.social #EASL2025, discussing the promise of #microbiome related therapies in #PSC #cholestatic liver disease - where have we come since the original #FMT #PSC pilot study by @DrAllegrettiIBD? doi.org/10.14309/ajg...

The future of nephrology in 2050 As medicine advances at an unprecedented pace, the field of nephrology is poised for transformative change. By 2050, breakthroughs in kidney disease p…

📘 What could nephrology look like in 2050?
This article for the Future Healthcare Journal was fun to write! — here’s a 🧵 of what might be coming next in kidney care:
shorturl.at/A18zK

This is brilliant - super clear and a must-have resource for who (and who not) to test in the clinic. Highly recommend!

New national genomics resources in Gastroenterology and Hepatology The National Genomics Education Programme have launched #GeNotes collection specifically for #Genomics cases in your practice. It is packed with educational scenarios written by experts in your field,...

The National Genomics Education Programme have launched #GeNotes collection specifically for #Genomics cases in your practice @britsocgastro.bsky.social www.bsg.org.uk/news/new-nat...

1. You feel powerless? Don’t know what you can do to resist the rise of fascism?
Here is an answer: Good Things.
Fascism inflicts pain and harm as a matter of doctrine.
Kindness, care and conviviality defend us from it.
The more we build community, the less it can take root.
🧵

A great first day at the #BSG #GutMicrobiome event, covering everything from early life @halllab.bsky.social, to #liver @debbieshawcross.bsky.social, to #cancer @jameskinross.bsky.social, and culminating in a tour de force on #IBD and the #microbiome in clinical practice from Prof Harry Sokol

Vacancies at the LMS View all the current vacancies at the MRC Laboratory of Medical Sciences, including research, technician, and support roles and jobs.

🚨 We're hiring! 🚨

The Chain Florey Transition-To-Independence Fellowship Scheme is open for applications! We have 3 positions available: 2 generic and 1 cardiology specific.

If you're a clinician scientist this is your chance to join the Chain Florey program!

Don't miss out—apply now! 💼👇

Wondering if your patient with small bowel inflammation has Crohn's vs intestinal TB?
Summarize all of your data with this website to get a probability. Add new (projected) test results to see how new results would change the estimate. #IBD
www.pathology.med.umich.edu/shiny/tbcroh...

Really enjoyed working on this review for Frontline Gastroenterology. How do anti-IL23 therapies work? What’s the evidence for their use in IBD? And is there any guidance on how we should position them in the treatment landscape?

fg.bmj.com/content/earl...

Pleased that #FARGO - a randomised, multicentre, placebo-controlled phase IIa trial of #FMT to treat #PSC - is running and recruiting. Have a look at the protocol paper out now in #BMJOpen: doi.org/10.1136/bmjo... @pscsupport.bsky.social @cholestasisdoc.bsky.social

Intestinal E. coli-produced yersiniabactin promotes profibrotic macrophages in Crohn’s disease
www.cell.com/cell-host-mi...

Check out the @mrc-lms.bsky.social Chain Florey clinician scientist programme for those interested in mechanistic discovery science and experimental medicine - 12-month predoctoral fellowships currently up for grabs!
lms.mrc.ac.uk/work-and-stu...

YouTube video by Francis Crick Institute IBD and Gene Deserts - with James Lee

What is inflammatory bowel disease (IBD) and how can a gene desert help us to understand its causes and potential future treatments? 🧬🧪

Hear the Crick's James Lee sharing his insights in the first in our series of Crick Crash Courses. www.youtube.com/watch?v=bcc8...

Mature tuft cell phenotypes are sequentially expressed along the intestinal crypt-villus axis following cytokine-induced tuft cell hyperplasia Intestinal tuft cells are epithelial sentinels that trigger host defense upon detection of parasite-derived compounds. While representing interesting targets for immunomodulatory therapies in inflamma...

New work on #tuft cells, rare guardians of our #gut against invaders. How they work is not known. We show that intestinal tuft types 1&2 are sequentially expressed phenotypes during differentiation. And…we can now generate mature immune-related tuft-2’s in #organoids for more 🔬🧫🧬🔥
shorturl.at/EImjA

We know everything about IL-33 already, right?

No! In fact we know very little about IL-33 in the colonic epithelium

Our recent paper finds IL-33 is highly enriched in colonic stem cells suggesting an immunoregulatory role for this niche in injury🧵

www.mucosalimmunology.org/article/S193...

PIEZO-dependent mechanosensing is essential for intestinal stem cell fate decision and maintenance Stem cells perceive and respond to biochemical and physical signals to maintain homeostasis. Yet, it remains unclear how stem cells sense mechanical signals from their niche in vivo. In this work, we ...

#LocationLocationLocation! Baghdadi, Kim &co show @science.org that intestinal stem cells #ISCs located at the bottom of the crypts sense a more rigid environment & activate PIEZO to tune their proliferation/differentiation maintaining gut physiology! doi.org/10.1126/scie...

#immunosky
The power of spatial information! ILC2s specifically in the middle of the colon express microbiota-induced genes that are important for the structural adaptation of this part of the gut. Loads of spatial data across different states (homeostasis vs inflammation) for the community.

👨‍🔬🎉Kicking off my bluesky presence by posting our lab's achievement! Our lab's first study is now out in Cell ! We show that IFN-λ induces ZBP1/CASP-8/GSDMC-dependent pyroptosis in gut epithelial cells impairing tissue repair post-colitis.#IBD #Immunology 🧵https://authors.elsevier.com/a/1k2OAL7PXqSL5

Happy to share the work from my residency at #Charite available as pre-proof version in #Gastroenterology.

We identify Ki67+ memory CD4+ T cells as robust blood-based predictor for non-response to #vedolizumab (anti-integrin a4b7) in #IBD patients before therapy.

doi.org/10.1053/j.ga...

T cell mediated impairment of epithelial integrity in Crohn's disease T lymphocytes play a major role in intestinal homeostasis, with a particular impact on the balance between self-renewal and differentiation of intestinal epithelial cells (IECs). In Crohn's disease (C...

Very proud of this one. Sarah Hamoudi, PhD student in the lab, developed autologous cocultures between mucosal T cells and epithelial organoids from control or from patients with Crohn's disease.
www.biorxiv.org/content/10.1...