Intermittent #fasting makes your hair shorter and thicker (if you shave your hair previously), a new study in @cellpress.bsky.social reports www.cell.com/cell/fulltex...
The next big thing in Triple Negative Breast Cancer:
VEGF/PD-1 Bispecifics.
Wonderful discussion by Dr. Thomas Grinda on the prospects.
Several Phase III studies planned.
@oncbrothers.bsky.social @sabcs.bsky.social @oncoalert.bsky.social
Dr. Tesch poster looking at TILs in very young women (<40 yrs)
Including all tumor subtypes- TNBC, HR+ and HER-3
TILs vary by recent pregnancy, BRCA status etc.
Here TILs not associated w/ ethnicity
TILs again predict pCR
#SABCS24
@sabcs.bsky.social
@oncoalert.bsky.social
Great slide highlighting not only are TILs predictive of pCR...it also translates to being prognostic beyond pCR for good outcome and DFS.
Seems like we have a LOT of data on TILs now, why aren't they standardly provided on path reports???🧐
#SABCS24
@oncoalert.bsky.social
@sabcs.bsky.social
#SABCS24 #bcsm #OncSky #SurgSky
Dr. R Hills: Meta-analysis of 4 older RCTs of immediate vs deferred surgery in women w/ operable ER+ #breastcancer receiving adjuvant tamoxifen. Immed surgery ⬇️ local progression, distant mets, & BC mortality. NNT <7 to prevent 1 BC death.
cc @oncoalert.bsky.social
Do systemic responses to ICI (eg irAEs) associate w outcomes?
Nice use of existing basket studies by @pateloncology.bsky.social @eladsharonmd.bsky.social Razelle Kurzrock et al
Isolated tumor cells (ITCs) after neoadj can’t chemotherapy have frequently been considered positive lymph nodes when considering axillary management and adjuvant therapy.
Important global study that suggests, as @maryamlustberg.bsky.social notes, less may be more!
#bcsm
Anthracyclines and conversion factor
#oncsky
#chemotherapy #basics #cancer
You are what you consume. Screen time limits are the future.
“Together, the findings suggest that the information sought reflects mental state and shapes it, creating a loop that may perpetuate mental health problems.”
Now in JNCI “Pts w stage 1 & 2 breast cancer have excellent prognosis, yet account for >60% breast cancer–specific death due to large #. To ⬇️ breast cancer death, strategies neededed to identify,treat pts w/early stage BC w/ risk for recurrence” @oncoalert.bsky.social
doi.org/10.1093/jnci...
Cancer-induced systemic pre-conditioning of distant organs: building a niche for metastatic cells
www.nature.com/articles/s41...
2025 will be the Top 100 OncoInfluencers on @bsky.app
oncodaily.com/positive/bre...
There is not enough evidence for poor performance of cdk4/6i (abema in MonarchE) in patients with BRCA pathogenic mutations. These patients still
deserve adj cdk4/6i if they meet criteria. Nadia Harbeck discussing this topic in Bogota 🇨🇴
Would you sequence it after olaparib?
Correlative analysis of GeparNuevo #TNBC neoadj clinical trial by Denkert et al:
➡️Expression analyses of tumor biopsies at 3 time points
➡️Confirm role of immune & prolif signatures
➡️Stromal signature assoc w immunotherapy resistance
@oncoalert.bsky.social #BCSM
www.cell.com/cell-reports...
Excellent review, congrats. Really enjoyed it.
Very interesting focus on senescence in Nat Rev Mol Cell Biol! @natureportfolio.bsky.social . Concepts, protocols, therapies and many more.. www.nature.com/collections/... @oncosky 🧪
I am truly grateful for the opportunity to bring together with this paper the amazing people I have had the privilege of working with in the field of #immunotherapy. #bcsm #breastcancer
#OpenAccess
www.cancertreatmentreviews.com/article/S030...
What constitutes visceral crisis in #breast #cancer ? #bcsm
Updated treatment algorithms for breast cancer now include adjuvant ribociclib and inavolisib, along with key trial names. Thrilled to see we're truly running out of space in HR+ disease—progress is here, with much more to come for all breast cancer subtypes!
Only 3 weeks to #SABCS24, a meeting that promises to significantly impact the way we treat breast cancer. It will feature phase 3 data with novel SERDs, novel ADCs, immunotherapy, ctDNA monitoring, important biomarker analyses & so much more. Here’s my top 10 abstracts list— see you in San Antonio!
#Oncology
NEW Review explores the marked increase in #cancer in young people over the last few decades. Includes multiple hypotheses about why we’re seeing this & methods to test them. #OncoSky #MedSky #bcsm #crcsm #ayacsm #melsm #kcsm #pancsm #thyroidcancer
www.cell.com/action/showP...
Hello friends! Smells like clean air in here.
Let’s make it grow! 🦋
#DrugDevelopment
“Uncovering the anatomic & biological intricacies of residual disease will allow for ⬆️ precision in postneoadjuvant treatments, moving beyond the binary paradigm of RD vs path CR, toward more tailored rescue strategies.” 💯
#OncoSky #MedSky #bcsm
jamanetwork.com/journals/jam...
