Avezov lab

Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes Cells down-regulate protein synthesis when stressed to conserve energy and shift resources toward repair. We found that in some mammalian cells, including neurons, stress also resulted in the formatio...

Out now in @science.org
Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes | Science www.science.org/doi/10.1126/...

Thanks Felix, for your and Roger’s fantastic contribution. Your bespoke approach to visualisation of ER exit sites was truly invaluable

🙏

Thanks Edward, any time :)

🙏 This study was powered by fantastic collaborations — especially with @abelljonny.bsky.social & @joechambers.bsky.social with contribution form @felixmendu.bsky.social @lasergroup.bsky.social @franbottanelli.bsky.social 🔬🧠

www.nature.com/articles/s41...

Thanks Jonny for the generous creative effort, bottomless appetite to pushing the concept deeper. 🙏

Congrats Pierre and Edward!

Thanks Felix, for your and Roger’s fantastic contribution. Your bespoke approach to visualisation of ER exit sites was truly invaluable

🙏

Congratulations Edward and Pierre! Great work, I'm sure this will be a very useful tool for many in the field, including us :)

🙏 This study was powered by fantastic collaborations — especially with @abelljonny.bsky.social & @joechambers.bsky.social with contribution form @felixmendu.bsky.social @lasergroup.bsky.social @franbottanelli.bsky.social 🔬🧠

www.nature.com/articles/s41...

Our new paper's out: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity

With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule

rdcu.be/e3Ris

ER remodelling is a feature of ageing and depends on ER-phagy - Nature Cell Biology Donahue et al. show that ageing is associated with changes in ER morphology. ER-phagy drives age-associated ER remodelling through tissue-specific factors.

☕Donahue et al. show that #aging is associated with changes in ER morphology. ER-phagy drives age-associated ER remodeling through tissue-specific factors. #autophagy #longevity
bit.ly/40dNHEE

Our new paper's out: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity

With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule

rdcu.be/e3Ris

Good Morning! This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis www.cell.com/cell/fulltex...

DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease...

Out now in @science.org
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality | Science www.science.org/doi/10.1126/...

A CRISPR-based sequence proximity binding protein labelling system for scanning upstream regulatory proteins - Nature Plants The authors developed a CRISPR-based proximity labelling system to profile DNA-binding proteins in plants, especially the transcription factors of target genes, as exemplified by studies on the regula...

Check this out
TuroID attached to inactive Cas to identify transcription regulators 👇
www.nature.com/articles/s41...

Learn about #axon regulation in the EMBO | The Company of Biologists Workshop "Axonal degeneration and regeneration" in Onna-son, JP, 18–22 Oct.

Abstract submission/Registration by 31 May/15 Jun

https://meetings.embo.org/event/26-axonal-degeneration
#EMBOAxonalRegeneration #EMBOevents #meeting 🧪

Introducing Cyclically Multiplexed Expansion Microscopy (Cy-ExM): a workflow for 3D nanoscale, high-plex imaging in whole cells. Cryo-preserved ultrastructure + iterative labeling + expansion microscopy → 20 targets in one dataset with ~70 nm lateral resolution.

www.biorxiv.org/content/10.6...

Excitation and emission spectra

mSumireF a Monomeric Violet Fluorescent Protein:
pubs.acs.org/doi/full/10....

A hefty harvest of PhDs this year from our lab. Congratulations to Drs Karnika G, Lise S, Cecile C, Valentina D and Yilin X MPhil! 🎓

A hefty harvest of PhDs this year from our lab. Congratulations to Drs Karnika G, Lise S, Cecile C, Valentina D and Yilin X MPhil! 🎓

A glittery, festive #FluorescenceFriday today, spent playing with some fun samples 🪩🕺

Last week to submit an abstract to the "Intracellular mechanics and organelle mechanobiology" EMBO workshop #EMBOmechanobio 👇

Cartoon with principle of Flash-away and images of cells

FLASH-AWAY: Intrabody-Directed Targeting of Optogenetic Tools for Protein Degradation: pubs.acs.org/doi/10.1021/...

Induced proximity-based therapeutic modalities - Nature Reviews Drug Discovery Induced proximity modalities encompass monovalent and bifunctional agents, such as molecular glues and proteolysis-targeting chimeras, that induce an interaction between biomolecules to functionally m...

Induced proximity-based therapeutic modalities
nature.com/articles/s41...
rdcu.be/eOfBH

This new Review by @dannomura.bsky.social et al. discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more

New preprint from our lab! ER geometry sets the tempo of neuronal bursting via Ca²⁺ store-refill—revealing selective neuronal vulnerability to ER-structure problems. Thread to follow.🧠⚡️

www.biorxiv.org/content/10.1...

#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv

New preprint from our lab! ER geometry sets the tempo of neuronal bursting via Ca²⁺ store-refill—revealing selective neuronal vulnerability to ER-structure problems. Thread to follow.🧠⚡️

www.biorxiv.org/content/10.1...

#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv

Join us for the first @embo.org meeting on Intracellular mechanics and organelle mechanobiology! Registrations are open, submit your abstract by November 14: we have plenty of slots for short talks! #EMBOMechanobio

Better together: researchers discover how cells keep groups of proteins in check Researchers have discovered a new biological process that they’ve called ‘interstasis’, a way for cells to promote the equilibrium of functionally-related proteins, preventing too many from accumulati...

Researchers led by Prof Jernej Ule (@ulelab.bsky.social)
have discovered a new biological process that they’ve called ‘interstasis’ - a way for cells to keep groups of proteins in check💡

The team are now exploring the role of interstasis in neurodegeneration ⬇️ www.crick.ac.uk/news/2025-09...

Rethink? 🤔Factros presumed to be exported as signal molecules turn out to function inside the cell, working with ER HSP70/Bip - solid structural data for CDNF
www.biorxiv.org/content/10.1...

and MANF before www.nature.com/articles/s41...

and the reverse is also true ... factors believed to exert their functions inside playing roles outside ....