Avezov lab

New preprint from our lab! ER geometry sets the tempo of neuronal bursting via Ca²⁺ store-refill—revealing selective neuronal vulnerability to ER-structure problems. Thread to follow.🧠⚡️

www.biorxiv.org/content/10.1...

#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv

New preprint from our lab! ER geometry sets the tempo of neuronal bursting via Ca²⁺ store-refill—revealing selective neuronal vulnerability to ER-structure problems. Thread to follow.🧠⚡️

www.biorxiv.org/content/10.1...

#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv

Join us for the first @embo.org meeting on Intracellular mechanics and organelle mechanobiology! Registrations are open, submit your abstract by November 14: we have plenty of slots for short talks! #EMBOMechanobio

Better together: researchers discover how cells keep groups of proteins in check Researchers have discovered a new biological process that they’ve called ‘interstasis’, a way for cells to promote the equilibrium of functionally-related proteins, preventing too many from accumulati...

Researchers led by Prof Jernej Ule (@ulelab.bsky.social)
have discovered a new biological process that they’ve called ‘interstasis’ - a way for cells to keep groups of proteins in check💡

The team are now exploring the role of interstasis in neurodegeneration ⬇️ www.crick.ac.uk/news/2025-09...

Rethink? 🤔Factros presumed to be exported as signal molecules turn out to function inside the cell, working with ER HSP70/Bip - solid structural data for CDNF
www.biorxiv.org/content/10.1...

and MANF before www.nature.com/articles/s41...

and the reverse is also true ... factors believed to exert their functions inside playing roles outside ....

Rethink? 🤔Factros presumed to be exported as signal molecules turn out to function inside the cell, working with ER HSP70/Bip - solid structural data for CDNF
www.biorxiv.org/content/10.1...

and MANF before www.nature.com/articles/s41...

This week's selection of #preprints and articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

🗣️: 4 #preprints from
@qilabuva.bsky.social lab on SEL1L-HRD1 in ERAD
doi.org/10.1101/2025...
doi.org/10.1101/2025...
doi.org/10.1101/2025...
doi.org/10.1101/2025...

Left: LaBeRling contact sites between the plasma membrane (green) and the endoplasmic reticulum (magenta). Contacts are highlighted in blue using LBR. Image created by Laura Downie. Right: 3D render of a membrane contact site (orange) between a mitochondrion (pink) and the ER (green contours). Image created by Stephen Royle.

#ER - #membrane contact sites are often distorted by existing labeling methods. @steveroyle.bsky.social &co present an inducible labeling system (LaBeRling) using #LaminB receptor to fluorescently tag ER-membrane contact sites in live cells, preserving morphology @plosbiology.org 🧪 plos.io/4lv6gxu

Mitochondrial origins of the pressure to sleep - Nature Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.

Check this out 👇fly sleep and organelle
morphology changes www.nature.com/articles/s41...

ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox Maintenance of mitochondrial redox homeostasis is of fundamental importance to cellular health. Mitochondria harbor a host of intrinsic antioxidant defenses, but the contribution of extrinsic, nonmito...

ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox www.science.org/doi/10.1126/...

. @whiteheadinstitute.bsky.social researchers developed Perturb-Multimodal, a powerful new approach that simultaneously measures how genetic changes affect both #GeneExpression and cell structure in intact liver tissue.

📰: bit.ly/440TrVi
📝 @cellpress.bsky.social: bit.ly/3TEs2ST

Researchers identify lost genetic messages as a target for treating dementia Researchers at the Francis Crick Institute and UCL have shown that genetic messages are misplaced in nerve cells in a model of Alzheimer’s disease and frontotemporal dementia.

Researchers at the Crick and UCL have developed laboratory models of dementia, including Alzheimer's, to show that certain genetic messages are misplaced in diseased nerve cells.

The finding could offer a potential target for new treatments for neurodegeneration.

www.crick.ac.uk/news/2025-06...

Sketch of membrane-enclosed compartment with particles on its surface, which interact with an adjacent structure

🧵 🧪 1/ Hi! I’m excited to share our latest work, now on arXiv:

Repulsive particle interactions at cellular interfaces enable selective information processing (arxiv.org/abs/2506.14739)

Where we explore how the physical properties of living systems can help cells process spatial information.

Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀

Researchers led by @clairedurrant1.bsky.social have used living human brain tissue to show for the first time how a toxic protein in Alzheimer’s can damage synapses👏

The team hope the cutting-edge tool could help accelerate the development of new treatments👉 buff.ly/cXK2LIa

Check out the latest version of MemBrain, spearheaded by computation superstar @lorenzlamm.bsky.social ! It can segment, pick particles and give you metrics on everything!

In developing embryos, cells move a lot! Plenty of that movement is random. Is random cell mixing a feature or bug for tissue patterning? Turns out, it’s both! Excited to share the 1st preprint from my postdoc w/ Sean Megason @seanemcgeary.bsky.social and Allon Klein. 1/20 doi.org/10.1101/2025...

This is one to watch 🔬Congratulations!

A room full of microscopy enthusiasts, Cambridge Microscopy Meeting 2025. #CMM2025

DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning - Nature Neuroscience Researchers developed DELTA, a method for brain-wide measurement of synaptic protein turnover with single-synapse resolution, providing a powerful tool to localize and study mechanisms underlying syna...

Honored to help enable two back-to-back papers in @natureneuro.bsky.social; first DELTA www.nature.com/articles/s41... with collaborators at @hhmijanelia.bsky.social and then EPSILON www.nature.com/articles/s41... with @adamezracohen.bsky.social; @dyerfulchymist.bsky.social is always in the mix!

Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway Nature Reviews Molecular Cell Biology - Coat protein complex II (COPII) subunits assemble to form membrane transport carriers at ER exit sites, thereby concentrating secretory cargoes and...

I am thrilled to announce my and @giuliazanetti.bsky.social's latest review "Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway" in @natrevmcb.bsky.social with @springernature.com.

Check it out here!
rdcu.be/eeY1J

#COPII #CryoEM #TeamTomo #MembraneTrafficking #ERES

ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes - Nature Communications Nixon-Abell et al. show that ANXA11 condensation on lysosomal membranes causes a coupled phase transition of the underlying lipids and mechanical stiffening of the overall ensemble involved in RNP gra...

😊 Very happy to see this out! A real group effort from the Hyslop lab (@thecimr.bsky.social) including brilliant collaborations with
@knowleslab.bsky.social,
Vendruscolo lab, @michael-e-ward.bsky.social lab,
@deriverylab.bsky.social lab,
@profmarciniak.bsky.social lab
🎉🎉🎉

GitHub - ChatMol/molecule-mcp: A model-context-protocol server for molecules. A model-context-protocol server for molecules. Contribute to ChatMol/molecule-mcp development by creating an account on GitHub.

github.com/ChatMol/mole...

YouTube video by Howard Hughes Medical Institute (HHMI) Energy on Demand #stem #stemeducation #shorts #science #DidYouKnow #YouTubeShorts #ShortsScience

This video, created by Andy Moore, a Research Scientist at @hhmijanelia.bsky.social, shows a cell w a dynamic network of endoplasmic reticulum (ER) tubules—present in every eukaryotic cell—as well as mitochondria migrating through the cell’s interior. The ER is orange, and the mitochondria are blue.

🤯 cryo-ET of copia viral-like particles lurking at the nuclear pore of intact Drosophila eggs!
Amazing work by @svenklumpe.bsky.social & more cool findings in this collaborative paper illuminating the replication cycle of an iconic retrotransposon!
www.cell.com/cell/fulltex...

Crick BioImage Analysis Sympsoium Logo

Calling all...
🔬 Microscopists
💻 BioImage Analysts
👩‍🔬 Life Scientists

📅 Save the Date

The 5th edition of the Crick BioImage Analysis Symposium will take place on November 24/25th 2025.

More details to follow...

#CBIAS2025

Reviewers should be paid. 🙃

Looks like very beautiful work. mRNA localisation in mature functional axons in vivo, and its role in long-term memory.

I was procrastinating making a smooth endoplasmic reticulum as the structure looks so complex when I remembered I can use metaballs! It is actually so much fun.

What are you procrastinating today that could actually be very fun?