Harshith C Y

Fig. 1.Four classes of roles of immune proteases illustrated via examples. (i) Pathogen perception: Required for Cladosporium Resistance-3 (Rcr3) protease is inhibited by the fungal avirulence effector Avr2. The Rcr3-Avr2 complex is recognized by the immune receptor Cf-2, triggering a defence response (Kruger et al, 2002). (ii) Regulation of the immune response: METACASPASE 4 (MC4) is activated by calcium upon wounding or pathogen attack. MC4 cleaves tonoplast-located ProPEP1 releasing PEP1 to the apoplast where it is perceived by PEP RECEPTORS (PEPRs) thereby initiating defence responses (Hander et al, 2019). (iii) Counteracting pathogen effectors: soybean aspartic protease GmAP5, degrades the Phytophthora sojae virulence factor glycoside hydrolase family 12 (GH12) protein, XEG1 (Xia et al., 2020). (iv) Direct pathogen attack: secreted aspartic proteases (SAPs) cleave Pseudomonas syringae MucD protein thereby suppressing bacterial growth (Wang et al., 2019).

💡 SPECIAL ISSUE VIEWPOINT 💡

Immune proteases are promising targets for protein engineering 🛠️ to boost disease resistance in plants 🌾 - Schuster et al.

🔗 doi.org/10.1093/jxb/...

#PlantScience 🧪 @marischuster.bsky.social @aciattoni.bsky.social

06.10.2025 10:32 — 👍 17    🔁 13    💬 1    📌 0

🧬 How have tiny immune-signaling peptides evolved across the plant kingdom?

Comparative analysis of small secreted peptide signaling during defense response: insights from vascular and non-vascular plants https://bit.ly/4eAUnmZ

16.08.2025 07:00 — 👍 8    🔁 3    💬 0    📌 0

Plant-associated fungi co-opt ancient antimicrobials for host manipulation Evolutionary histories of effector proteins secreted by fungal pathogens to mediate plant colonization remain largely elusive. While most functionally characterized effectors modulate plant immunity, ...

📣 NEW PREPRINT 📝

We identified evolutionary origins of many fungal effectors!
We show that fungi secrete lots of antimicrobial proteins, and that some of them were repurposed by plant pathogens for host immune suppression.
www.biorxiv.org/content/10.1...

cc @teamthomma.bsky.social

15.08.2025 07:46 — 👍 65    🔁 44    💬 1    📌 3

Ancestral P-body proteins rewired for autophagic recycling in the early land plant Marchantia polymorpha Processing bodies (P-bodies) are conserved ribonucleoprotein (RNP) granules central to RNA metabolism across eukaryotes. Although the mechanisms underlying their assembly are well understood, the path...

If you’re enjoying some calm while others are on holiday, here’s a #NEW #preprint to dive into — led by the brilliant @vbcscitraining.bsky.social student A. Abdrakhmanov:
👇 A quick thread + link:
www.biorxiv.org/content/10.1...

11.08.2025 05:44 — 👍 55    🔁 28    💬 4    📌 3

Unlocking expanded flagellin perception through rational receptor engineering - Nature Plants Receptor kinase FLS2 detects the flg22 epitope of bacterial flagellin. Here the authors identify key residues on FLS2’s concave surface that enable expanded perception of flg22 variants, allowing the ...

Excited this paper is finally published! We focused on the inner concave surface of LRR RKs to expand bacterial flagellin perception in plants. Selection indicates expanded perception is more common than previously thought. Experiments led by @jerrytli.bsky.social www.nature.com/articles/s41...

29.07.2025 01:20 — 👍 107    🔁 45    💬 10    📌 1

Very nice work and enjoyable read! Congratulations to the team 👏

31.07.2025 16:09 — 👍 0    🔁 0    💬 0    📌 0

Uncertainty in the timing of diversification of flowering plants rests with equivocal interpretation of their fossil record royalsocietypublishing.org/doi/10.1098/...

06.07.2025 08:56 — 👍 21    🔁 11    💬 0    📌 0

Bacteria that possess a type VI secretion system (T6SS) inject toxins directly into neighboring cells that may be competing for local resources. Toxins break down the cell wall of susceptible cells, causing the release of nutrients that the attacking bacteria can consume for growth and proliferation. However, this can cause spatial segregation of the bacterial cell population, restricting attacks to the boundaries of predator cell groups and prey cell groups. This might limit the number of cells that can leverage the T6SS system for predation.

Bacteria leverage a secretion system to kill and scavenge nutrients from nearby competitors.

Learn more in a new #SciencePerspective: scim.ag/44y3iC6

28.06.2025 14:07 — 👍 70    🔁 15    💬 1    📌 2

Excited to share our #bioRxiv #preprint on HIR2, RLKs and membrane organisation in #Arabidopsis. We used many exciting techniques like #sptPALM, #AlphaFold and #BN-PAGE 🌱

15.04.2025 05:24 — 👍 13    🔁 10    💬 0    📌 1

Plant cell wall structure and dynamics in plant–pathogen interactions and pathogen defence This review discusses the role of plant cell walls in determining plant resistance and highlights the contributions of the host, pathogens, and multifactor

📜 Plant cell wall structure and dynamics in plant–pathogen interactions and pathogen defence

🧑‍🔬 Kristina S. Munzert, Timo Engelsdorf

📔 @jxbotany.bsky.social

🔗 academic.oup.com/jxb/advance-...

#️⃣ #PlantScience #PlantImmunity #DarwinReview #PlantCellWalls

10.12.2024 11:08 — 👍 17    🔁 7    💬 0    📌 0