Nico Dosenbach's Avatar

Nico Dosenbach

@ndosenbach.bsky.social

David M. & Tracy S. Holtzman Professor, Neurology @ WashU School of Medicine; precision neuroimaging, network plasticity, BWAS ≠ fMRI, action mode; #neuroscience #neurology #openscience #science dosenbachlab.wustl.edu

1,713 Followers  |  2,324 Following  |  115 Posts  |  Joined: 29.11.2023
Posts Following

Posts by Nico Dosenbach (@ndosenbach.bsky.social)

It's a pretty funny criticism because

1) the data are sourced from a public database, NIH RePORTER
2) "Deranged activist" Jeremy Berg was an NIH institute director for 7 years

and most importantly
3) Thacker admits the story is totally accurate

02.03.2026 20:51 — 👍 124    🔁 31    💬 8    📌 5
Preview
'One year of failure.' The Lancet slams RFK Jr.'s first year as health chief In a scathing review, the top US medical journal's editorial board warned that the "destruction that Kennedy has wrought in 1 in office might take generations to repair."

In a scathing review, the top US medical journal's editorial board warned that the "destruction that Kennedy has wrought in 1 in office might take generations to repair." n.pr/3N9Foa8

28.02.2026 20:55 — 👍 2097    🔁 713    💬 75    📌 52

A recent @natneuro.nature.com paper analyzed lesion network mapping and raised concerns about the validity of the method.
See below 👇 for our response.

www.biorxiv.org/content/10.6...

27.02.2026 07:27 — 👍 44    🔁 25    💬 1    📌 1
Personalized brain decoding of spontaneous pain in individuals with chronic pain - Nature Neuroscience Lee et al. show that personalized brain-decoding models derived from intensive longitudinal fMRI data can track spontaneous pain in individuals with chronic pain, highlighting the potential of precise...

New paper in Nature Neuroscience! We developed personalized fMRI-based predictive models tracking ongoing spontaneous pain in chronic pain patients—trained on 6+ months of densely sampled data. A true team effort. Deeply grateful to our participants! doi.org/10.1038/s41593-026-02221-3

26.02.2026 13:30 — 👍 29    🔁 10    💬 1    📌 0
Post image

Nico Dosenbach, MD, PhD, among other researchers, has identified the somato-cognitive action network (SCAN) as the brain network responsible for Parkinson's disease. The study also found targeting SCAN with non-invasive TMS greatly improves symptoms.
https://bit.ly/4adziNp

25.02.2026 17:07 — 👍 5    🔁 1    💬 0    📌 0

A newly discovered Alzheimer’s “clock” may be ticking in the blood. Read how Suzanne E. Schindler, MD, PhD, and team built a model using blood tests to estimate when symptoms could begin — opening new possibilities for earlier diagnosis and prevention.

19.02.2026 21:04 — 👍 5    🔁 1    💬 0    📌 0
Preview
New approach roughly predicts when Alzheimer’s symptoms begin The technique is not yet precise enough to predict a patient’s exact trajectory but could help find long-sought preventive treatment.

New approach roughly predicts when Alzheimer’s symptoms begin
The technique is not yet precise enough to predict a patient’s exact trajectory but could help find long-sought preventive treatment.

wapo.st/4kHZYuC

20.02.2026 11:59 — 👍 1    🔁 1    💬 0    📌 0
Preview
This complex brain network may explain many of Parkinson's stranger symptoms Parkinson's disease appears to disrupt a brain network involved in everything from movement to memory.

Parkinson's disease appears to disrupt a brain network involved in everything from movement to memory. n.pr/4kpKWtv

10.02.2026 11:03 — 👍 223    🔁 47    💬 4    📌 6
Preview
Here's how a year of RFK, Jr., has changed American science After a year of RFK, Jr., heading the Department of Health and Human Services, the “Make America Healthy Again” movement has upended science and medicine

After a year of RFK, Jr., heading the Department of Health and Human Services, the “Make America Healthy Again” movement has upended science and medicine

13.02.2026 15:53 — 👍 61    🔁 25    💬 7    📌 7
Preview
Ritalin Works-But Not the Way We Thought - Common Reader ADHD, sleep deprivation, amphetamines and the truth of why they work

@jcooperman.bsky.social proves essay writing is *not* a lost art in her engaging, in-depth write-up of our latest research on stimulant drugs. I highly recommend her journalism, and you can find the science published in the journal Cell.
commonreader.wustl.edu/adhd-and-rit...
doi.org/10.1016/j.ce...

12.02.2026 23:53 — 👍 5    🔁 1    💬 0    📌 0
Post image

Today's anti-science pairing

13.02.2026 15:10 — 👍 255    🔁 104    💬 6    📌 5
Preview
AI help in grant proposals tied to higher funding odds at NIH But funding proposals to US agencies also tend to be more similar to previously funded projects if they are written or edited with the help of a chatbot.

Scientists are increasingly turning to AI chatbots for help drafting the grant proposals that fund their careers.

Preliminary data indicate that these tools are linked with a slightly higher funding rate and might be pulling the focus of research towards safe, less-innovative ideas.

12.02.2026 22:05 — 👍 21    🔁 8    💬 1    📌 1

NEW: Another NIH institute director hasn't been renewed — the director of NIAMS (arthritis, musculoskeletal and skin diseases institute).

That leaves a whopping 15 of 27 institutes and centers without a permanent director.

12.02.2026 17:16 — 👍 143    🔁 99    💬 2    📌 14
Post image

Objective Quality Assessment for Precision Functional MRI Data | bioRxiv www.biorxiv.org/content/10.6...

13.02.2026 01:10 — 👍 10    🔁 3    💬 0    📌 0
Preview
Your Job Isn't Disappearing. It's Shrinking Around You in Real Time AI isn't taking your job. It's making your expertise worthless while you watch. The three things everyone tries that fail, and the one strategy that actually works.

"The meta-skill is learning to continuously spot the next evolution and position yourself at the edge of what’s newly possible." That sounds really tiring. newsletter.jantegze.com/p/your-job-i...

13.02.2026 01:13 — 👍 15    🔁 1    💬 0    📌 0
Preview
Ritalin Works-But Not the Way We Thought - Common Reader ADHD, sleep deprivation, amphetamines and the truth of why they work

Ritalin doesn't hit the attention centers after all--and it might help prevent dementia--and ADHD is a continuum for all of us--but sometimes it's misdiagnosed sleep-deprivation... One big study can reveal a lot. (AUDIO 8m) commonreader.wustl.edu/adhd-and-rit...

11.02.2026 15:55 — 👍 3    🔁 1    💬 1    📌 0
Preview
Brain network dysfunction central to Parkinson's disease identified - New Zealand News Beep Researchers led by Beijing"s Changping Laboratory have identified a specific brain network whose dysfunction appears central to Parkinson's disease, a finding

Brain network dysfunction central to Parkinson’s disease identified

https://www.newsbeep.com/nz/279712/

Researchers led by Beijing”s Changping Laboratory have identified a specific brain network whose dysfunction appears central to Parkinson’s…

12.02.2026 03:00 — 👍 1    🔁 1    💬 0    📌 0
Preview
Parkinson's May Emerge From a Deeper Brain Network Than We Thought Targeting it vastly improved treatments.

📰 Parkinson's May Emerge From a Deeper Brain Network Than We Thought

Targeting it vastly improved treatments.

12.02.2026 11:11 — 👍 2    🔁 1    💬 0    📌 0
Preview
Parkinson's May Emerge From a Deeper Brain Network Than We Thought A recently discovered brain network may be the core circuit underlying symptoms of Parkinson's disease.

Parkinson's May Emerge From a Deeper Brain Network Than We Thought. Via @sciencealert #MedicalScience 💉💊🏥🩸😷

12.02.2026 12:20 — 👍 1    🔁 1    💬 0    📌 0

Breakthrough @nature.com study showcases new non-invasive treatment for Parkinson’s Disease that targets the somato-cognitive action network (SCAN) with personalized neuromodulation, for superior outcomes. www.nature.com/articles/s41...

08.02.2026 04:16 — 👍 56    🔁 25    💬 0    📌 1

Don’t miss out reading about this amazing work linking the SCAN to Parkinson’s disease. What are the best ways we could use this new knowledge?!

10.02.2026 17:03 — 👍 5    🔁 4    💬 0    📌 0

This complex brain network may explain many of Parkinson's stranger symptoms https://www.npr.org/2026/02/10/nx-s1-5702451/parkinsons-disease-symptoms-scan-network?utm_source=dlvr.it&utm_medium=mastodon

10.02.2026 11:12 — 👍 2    🔁 1    💬 0    📌 0
Preview
This complex brain network may explain many of Parkinson's stranger symptoms

📢 Parkinson's disease appears to disrupt a brain network involved in everything from movement to memory.

10.02.2026 11:16 — 👍 1    🔁 1    💬 0    📌 0
Preview
This complex brain network may explain many of Parkinson's stranger symptoms Parkinson's disease appears to disrupt a brain network involved in everything from movement to memory.

This complex brain network may explain many of Parkinson's stranger symptoms #Science #HealthandMedicine #Neurology #ParkinsonsDisease #Neuroscience #BrainResearch

https://www.npr.org/2026/02/10/nx-s1-5702451/parkinsons-disease-symptoms-scan-network

10.02.2026 11:44 — 👍 3    🔁 2    💬 0    📌 0
Preview
This complex brain network may explain many of Parkinson's stranger symptoms Parkinson's disease appears to disrupt a brain network involved in everything from movement to memory.

This complex brain network may explain many of Parkinson's stranger symptoms www.npr.org/2026/02/10/n...

10.02.2026 18:09 — 👍 2    🔁 1    💬 0    📌 0
Preview
Brain network responsible for Parkinson's disease identified A brain network first identified by Washington University in St. Louis School of Medicine researchers, called SCAN, is shown in a new study to be the neurological basis for Parkinson's disease. Patients receiving treatments targeted to this brain region...

#ResearchSky Parkinson’s affects movement, sleep, and thinking, and current treatments can’t stop it.

A new study led by WashU pinpoints the brain network underlying the disease and shows that targeting it can dramatically improve symptoms without surgery. https://bit.ly/4tpIjfh

10.02.2026 18:23 — 👍 1    🔁 1    💬 0    📌 0
Preview
Parkinson’s disease as a somato-cognitive action network disorder - Nature The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.

More excellent reporting by NPR's Jon Hamilton about a new brain network that explains symptoms of Parkinson's that have befuddled brain researchers for decades. Kudos to @jianxunren.bsky.social and Hesheng Liu for this groundbreaking research in the journal Nature! doi.org/10.1038/s415...

10.02.2026 18:32 — 👍 4    🔁 6    💬 0    📌 0

Parkinson's is what an *actual* dopamine fast looks like: it's caused by degeneration of dopamine cells involved in motivation and movement. Also why antipsychotic drugs that block dopamine can cause Parkinsonism. Reducing pleasurable activity doesn't cut dopamine; it doesn't work that way.

10.02.2026 18:38 — 👍 7    🔁 2    💬 0    📌 0
Preview
Parkinson’s disease as a somato-cognitive action network disorder - Nature The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.

Big news for Parkinson's disease from the world of brain circuit science.

www.nature.com/articles/s41...

11.02.2026 13:27 — 👍 4    🔁 2    💬 0    📌 0
Preview
Parkinson’s disease as a somato-cognitive action network disorder - Nature The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.

In case this important point gets overlooked: along with our Nature paper, we’ve publicly released two large and scarce datasets—PIPD and PIET. IMHO, these are the best open Parkinson's and Tremor datasets available to date.
See threads (1/4) 👇
nature.com/articles/s41...

10.02.2026 01:56 — 👍 21    🔁 15    💬 1    📌 0