Misha Rosenbach, MD

Botulinum toxin injections were associated with high complete response rates for acute digital ischemia (93.1%), ischemic ulcers (90.1%), and gangrene (87.5%), with minimal adverse events. ja.ma/4rqaCs9

This case report describes a patient with a history of refractory acute myeloid leukemia who presented with white, spiny hyperkeratotic papules on his face and neck, and was subsequently diagnosed with trichodysplasia spinulosa. bit.ly/4tjXhDl

📄 This case report describes large areas of erythema on the face, chest, and back with relatively clear boundaries and swollen hands with scattered skin-colored papules and nodules.

bit.ly/3ZgXYQe

A woman in her 70s with rheumatoid arthritis who was receiving long-term immunosuppression (prednisolone and methotrexate) presented with a 6-month history of progressive papulonodules on her face and extremities.

📝 Take the Clinical Challenge:
ja.ma/4buHnzH

Among patients with juvenile dermatomyositis, intermittent intravenous methylprednisolone pulse plus mycophenolate mofetil led to complete clinical response and remission in 93% of patients after a median 36 months of follow-up. ja.ma/4bG4449

A man in his 30s presented with a 2-month history of hair loss on the entire scalp and the lateral portions of both eyebrows. Results of the hair-pull test were negative.

What is your diagnosis?

ja.ma/4661hgW

Anifrolumab treatment in #LupusErythematosus was associated with significant reductions in systemic and cutaneous disease activity, while SIGLEC-1 expression decreased alongside clinical improvement.

ja.ma/4reY1YX

Case report describes a patient in his 50s with immunoglobulin A vasculitis with monoclonal B-cell lymphocytosis who was successfully treated with zanubrutinib after failure of multiple treatments. ja.ma/49HVRuF

Activating #EGFR variants were identified in early-onset, severe generalized #AcanthosisNigricans with pulmonary nodules; EGFR inhibitor therapy improved both skin and lung disease. ja.ma/4bw0Rnp

A 20-year-old woman presented with 9 days of pain and decreased vision in the right eye, as well as 2 weeks of a rash and gum swelling. Fever, dyspnea, and hemoptysis developed. Read the full case details: nej.md/45acJaR

#MedSky #DermSky #Ophthalmology

This case report describes a man in his 30s who presented for evaluation of a 3-week history of irritation, redness, and photophobia in both eyes.

ja.ma/3KOUwsx

Botulinum toxin injections were associated with high complete response rates for acute digital ischemia (93.1%), ischemic ulcers (90.1%), and gangrene (87.5%), with minimal adverse events.

ja.ma/4phELs4

Lamellar ichthyosis (LI) is a rare autosomal recessive disorder characterized by widespread, thick, platelike scales.

This case report describes 2 siblings in their 20s with lamellar ichthyosis treated with acitretin and dupilumab. ja.ma/45mH99S

A woman in her 70s presented with a 5-year history of pruritic, thickened plaques involving the trunk and extremities. Despite intermittent treatment with antihistamines and glucocorticoids, the condition progressed.

Read the full case report: ja.ma/49kbXJD

An adolescent female presented with 3 days of progressive abdominal pain and reported that a rash first appeared nearly 1 year earlier on her left wrist and gradually spread over several weeks.

What is your diagnosis? ja.ma/4qItEcH

A 38-year-old woman presented with a 12-month history of annular plaques on the forehead, cheeks, and neck. Skin biopsy revealed noncaseating epithelioid granulomas with sparse lymphocytic infiltration in the superficial dermis. Read the full case details: nej.md/3L26Llk

#MedSky #DermSky #PulmSky

An 80-year-old man presented with a 4-day history of a rash on his abdomen. Physical examination was notable for periumbilical erythema and a small gray protrusion in the umbilicus. Read the full case details: nej.md/4pYF5NO

@i-med.ac.at #MedSky #DermSky

A registered report megastudy on the persuasiveness of the most-cited climate messages - Nature Climate Change How to effectively communicate climate change to the public has long been studied and debated. Through a registered report megastudy, researchers tested the ten most-cited climate change messaging str...

So little was known 18 years ago when I started researching climate comms. I'm blown away by how much we now know. This study, led by the incomparable Jan Voelkel with his all-star band, and released today in @natclimate.nature.com confirms that many distinct message strategies can work...

This is purpura fulminans, a severe complication of meningitis (which as of today is no longer on our universal vaccine schedule)

Micro clots & bleeding into the skin cause skin & tissue death. It’s more common in kids & associated with 20-70% mortality.

Those who survive often lose limbs.

Year 1 data on congestion pricing in Manhattan…

* Vehicle traffic: -11%
* Foot traffic: +3.4%
* Storefront vacancy: -0.9%
* Pollution: -22%
* Revenue for mass transit: $548M

So YES this has been a huge success.

The US #measles count for this year has topped 2,000 cases for the first time since 1992. These are confirmed cases only, ie there have been more. 3 reported deaths.
The vast majority of the cases are in unvaccinated kids & adults. 11% needed hospitalization. www.cdc.gov/measles/data...

In a Review Article on measles, Lien Anh Ha Do, MD, PhD, and Kim Mulholland, MB, BS, MD, review the epidemiology, clinical presentation, and associated illnesses as well as treatment and prevention strategies. Read the full review: nej.md/4lmC1Ir

#MedSky #PedSky #IDSky

A 72-year-old woman presented with a 3.5-month history of an enlarging, painless lump on her cheek. Examination showed a dome-shaped, reddish nodule on the left cheek, with a shiny surface and central hemorrhagic crust. Read the full case details: nej.md/3MDwXU5

#MedSky #DermSky #Oncology

Great image
& Technically #IDSky too!

HPV vaccination could prevent most cervical cancers, but only 27% of eligible adolescent girls worldwide have received the vaccine. Data suggest that a single dose may be protective. Research findings from the ESCUDDO trial are summarized in a new Quick Take video. nej.md/3MFcHBr

#MedSky #IDSky

Monthly vixarelimab led to rapid and sustained improvement in pruritus and lesion severity for adults with #PrurigoNodularis, with no serious drug-related adverse events reported.

ja.ma/4pOaUJ4

NCAR is quite literally our global mothership.

Everyone who works in climate and weather has passed through its doors and benefited from its incredible resources.

Dismantling NCAR is like taking a sledgehammer to the keystone holding up our scientific understanding of the planet.

Unbelievable.

Botulinum toxin injections were associated with high complete response rates for acute digital ischemia (93.1%), ischemic ulcers (90.1%), and gangrene (87.5%), with minimal adverse events.

ja.ma/4rV9dLc

A report by Chloé Grolleau et al., "Single-cell profiling of lichen planus reveals type I interferon response triggering the interface dermatitis reaction" https://doi.org/10.1016/j.jid.2025.04.043 #JIDJournal #DermatologyJournal #dermatology #dermatologists #dermresearch #dermscience #dermsky

Case Record of the MGH: A 5-year-old boy was admitted to the hospital because of fever and rash. Nonblanching papules spread from the feet to the legs, buttocks, lower back, arms, and ears. A diagnostic test was performed. Read the full case details: nej.md/4rV135I

#MedSky #DermSky