Andrea Luppi

9/ Wonderful collaboration with extremely talented colleagues: Hana Ali, @zhenqi.bsky.social , Filip Milisav, @gozziale.bsky.social , Danilo Bzdok, & @misicbata.bsky.social (& thanks to our AI neuroscience experts 🤖 of course!)

GitHub - Hana-Ali/neuroLLM Contribute to Hana-Ali/neuroLLM development by creating an account on GitHub.

8/ The Big Picture

To sum up: AI-powered synthesis of the neuroscience literature brings together a scattered literature to identify emergent patterns across disparate subfields, modalities, and species.

Try it yourself with our GitHub repo: github.com/Hana-Ali/neu...

7/ Mapping disorder involvement ⚕️

We derive regional risk maps for 30+ brain disorders 🧠🩹. Their clustering aligns with official ICD-11 clinical classification 🩺 better than clustering maps of risk-gene expression 🧬, & recover symptom co-morbidities

6/ From shared function to shared co-activation

Regions’ LLM-derived cognitive similarity predicts functional co-activation from fMRI, and effects of direct stimulation ⚡️ better than anatomical connectivity, molecular profile, or spatial proximity - also in 🐭&🐒

5/ Conserved molecular circuits for cognition 🧬🧠

We can also extend to macaque🐒 & mouse🐭 previous human studies based on NeuroSynth (Hansen 2021 Nat Hum Behav; Luppi 2024 Nat Biomed Eng). Integration w/ species-specific gene expression 🧬 reveals a cross-species molecular circuit for cognition

4/ A functional cortical hierarchy is latent in the literature

Asking the LLMs about regions and functions one-by-one spontaneously reveals a unimodal-transmodal functional hierarchy 🧠 matching species-specific anatomical hierarchy

3/ Unlocking Cross-Species Discovery 🐒🐭

We can use the LLM-generated maps to decode brain maps from other species. We show this with 🐒 macaque working memory & the recent Neuropixel maps of 🐭 mouse neural activity during cognitive tasks, from International Brain Laboratory (doi.org/10.1038/s415...)

2/ Beyond traditional meta-analysis

LLM maps go beyond traditional meta-analysis tools: they correlate better with 🧠 circuits derived from direct causal interventions from intracranial electrical stimulation ⚡️ and Lesion Network Mapping

1/ AI-driven cognitive mapping

We use Large Language Models (GPT-4, Gemini, Llama, Mistral, DeepSeek) as neuroscience experts, to synthesise the evidence that region X is involved in function/disorder Y. We can do this for humans but also macaque 🐒 & mouse 🐭

Cognitive cartography of mammalian brains using meta-analysis of AI experts The complexity of the brain is increasingly mirrored by the complexity of the neuroscientific literature, yet no individual mind can fully grasp the diversity of scales, methodologies and model organi...

🧠 Excited to share our latest preprint: Automated Brain Mapping with AI Experts!🤖

www.biorxiv.org/content/10.6...

Ever wanted to summarise the cognitive/systems neuroscience literature beyond MRI and PET? Ever wished we could do the same for macaque 🐒 and mouse 🐭 ? Read on! 🧵👇

Dr Andrea Luppi named ‘Rising Star in Neuroscience 2025’ Dr Andrea Luppi is among 25 researchers worldwide to be recognised by The Transmitter – a US-based publication for the neuroscience community. Rising Stars in Neuroscience 2025 honours early-career re...

Dr Andrea Luppi is one of 25 early-career researchers recognised for their outstanding scientific contributions and commitment to mentoring and community-building in neuroscience.
@thetransmitter.bsky.social
@stjohnscollege.bsky.social
www.eng.cam.ac.uk/news/dr-andr...

@loopyluppi.bsky.social & @frosas.bsky.social have written a reply. I recommend reading this as it clarifies their stance and advances the discussion:
www.nature.com/articles/s41...

I think this was a fruitful exchange. It was also a great experience to write this up w/ David in Amsterdam @ CCN2025

Just out in Nature Reviews Neuroscience! We've been studying information synergy within the brain for a few years now: here we explore how we can take this approach to the level of synergy *between* brains! 🧠🔄🧠
Thanks to @edoardochidichimo.bsky.social for making this inter-brain synergy possible!

Incredibly grateful to @misicbata.bsky.social for the nomination, and to him and my other mentors @estamatakis.bsky.social, David Menon, and Morten Kringelbach for having my back at every step of the way 🙏

The Transmitter’s Rising Stars of Neuroscience 2025 We recognize the outstanding achievements of 25 neuroscientists who stand to shape the field for years to come.

Truly honored to be recognized among @thetransmitter.bsky.social's Rising Stars of Neuroscience for 2025 next to trailblazers like @valeriejsydnor.bsky.social, @lindenmp.bsky.social, @elimuller.bsky.social & more!🌟🧠Check out everyone's full contributions at www.thetransmitter.org/early-career...