Nature Neuroscience

Astrocyte specification in the mouse septum is shaped by both developmental origin and local signals - Nature Neuroscience The relative contribution of intrinsic and extrinsic factors to astrocyte heterogeneity is unknown. Using heterotropic transplantation of septal astrocytes with distinct lineage origins, we show that ...

Astrocyte specification in the mouse septum is shaped by both developmental origin and local signals

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Sight of someone potentially infectious causes immune response, research suggests Scientists use VR headsets to see how participants react to faces of people showing signs of viral infections Whether it’s the person brandishing a tissue on the train or the child with the telltale signs of chickenpox, the threat of an infection can be enough for us to beat a retreat. Now researchers using virtual reality avatars have shown that the mere sight of a potentially contagious person is enough to mobilise our immune system too. Continue reading...

Sight of someone potentially infectious causes immune response, research suggests

The synaptic architecture of layer 5 thick tufted excitatory neurons in mouse visual cortex - Nature Neuroscience This study maps the connections of layer 5 pyramidal neurons in the mouse cortex, revealing distinct local and intercortical wiring patterns, and provides an open framework for exploring the connectiv...

The connectivity of mouse visual cortex thick tufted layer 5 pyramidal cells, also known as extratelencephalic neurons (L5-ETns), using a 1 mm3 publicly available electron microscopy dataset, part of the MICrONS Project

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Neural anticipation of virtual infection triggers an immune response - Nature Neuroscience Serino et al. show that seeing an infectious avatar approach the body in virtual reality triggers an immune response, indicating that the brain prepares the body to fight infections even for perceived...

Avatars who appear to be sick entering the peripersonal space in virtual reality are anticipated by multisensory–motor areas, activate the salience network, and trigger activation of innate lymphoid cells, mirroring responses seen in actual infections

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Lifespan changes in the human brain This cross-journal collection invites submissions that investigate human brain changes across all or multiple stages of life, from in-utero to older age.

📢 The new cross-journal Collection “Lifespan changes in the human brain” with @commsbio.nature.com, @natcomms.nature.com, @natneuro.nature.com, and Scientific Reports is now open for submissions! 📭

🌍 Learn more: www.nature.com/collections/...

#Neuroscience #Brain #Lifespan #Neuroimaging

Noradrenergic activation of the basolateral amygdala facilitates memory specificity for similar events experienced close in time - Nature Neuroscience Atucha et al. provide evidence that noradrenergic activation of the basolateral amygdala facilitates the formation of discrete memories of similar events experienced close in time via a miR-134-regula...

Noradrenergic activation of the BLA promotes the formation of discrete memories of similar events that were experienced close in time, via a miR-134-regulated consolidation process within the dentate gyrus of the hippocampus

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Multimodal cue integration and learning in a neural representation of head direction - Nature Neuroscience Basnak et al. show that particularly informative spatial cues produce a higher and narrower bump of activity in the Drosophila head direction system. More informative cues can instruct the remapping o...

Particularly informative spatial cues produce a higher and narrower bump of activity in the Drosophila head direction system. These informative cues can instruct the remapping of other cues to produce a self-consistent map.

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Voltage imaging reveals hippocampal inhibitory dynamics shaping pyramidal memory-encoding sequences - Nature Neuroscience Using voltage imaging, the authors show that interneurons in the hippocampus sharpen memory-encoding-activity by increasing the signal-to-noise ratio of pyramidal neuron sensory representations during...

Voltage imaging in mouse hippocampus reveals that interneurons sharpen memory encoding-activity by increasing the signal-to-noise ratio of pyramidal neuron sensory representations during working memory

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Evidence for trans-synaptic propagation of oligomeric tau in human progressive supranuclear palsy - Nature Neuroscience McGeachan et al. observe oligomeric tau in synapses from individuals with progressive supranuclear palsy and provide evidence that tau pathology may spread through the brain via synapses.

Evidence for trans-synaptic propagation of oligomeric tau in human progressive supranuclear palsy, including postmortem PSP brain samples and a living human brain slice culture model

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Associate or Senior Editor, Nature Neuroscience Title: Associate or Senior Editor, Nature Neuroscience Location(s): New York or Shanghai – Hybrid working model Application Deadline: August 18th About Springer Nature Springer Nature is one of the le...

We're hiring! Nature Neuroscience is hiring an Associate or Senior Editor with experience in cellular and molecular neuroscience, glia, and genomics to work in our New York or Shanghai office. Applications are due August 19.

springernature.wd3.myworkdayjobs.com/en-US/Spring...

Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex - Nature Neuroscience Ossenkoppele, Coomans and colleagues analyzed the tau PET data of 12,048 individuals from 42 cohorts worldwide. They found that age, amyloid-β status, presence of an APOE ε4 allele and female sex are ...

Tau PET positivity in individuals (42 cohorts worldwide, N = 12,048) with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex

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Synchronization of visual perception within the human fovea - Nature Neuroscience Combining behavioral data, electrophysiology and modeling, the authors show that the human brain synchronizes visual signals by adjusting axonal conduction speed in the retina, revealing a previously ...

The human brain synchronizes visual signals by adjusting axonal conduction speed in the retina—revealing a previously
unknown mechanism for precise perceptual timing

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Mapping human thalamocortical connectivity with electrical stimulation and recording - Nature Neuroscience Intracranial stimulation maps human brain causal connectivity, uncovering distinct pathways. The authors show that thalamic pulses uniquely evoke delayed theta oscillations, offering new insights into...

Stimulating and recording with intracranial electrodes implanted in cortical regions and thalamic nuclei across 4,864 sites in 27 human participants reveals distinct spectral signatures elicited by perturbations of specific brain areas

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Direct interactions between the human insula and hippocampus during memory encoding - Nature Neuroscience The hippocampus and insula communicate when processing emotional memories. Discrete sites in the human insular cortex showed changes that predicted later memory recall, while others responded to emoti...

Discrete sites in the human insular cortex showed changes of ac vity that predicted later memory recall, while others responded to emo onal content. Smula on of memoryrelated sites showed direct influence over the hippocampus

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Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease - Nature Neuroscience The dynamics of microglia states adjacent to or far from amyloid-beta plaques are unclear. Here the authors show that non-plaque-associated microglia modulate the cell population expansion in response...

Characterizing plaque-associated #microglia (PAM) and non-plaque-associated microglia (non-PAM) in a mouse model of Alzheimer's disease; non-PAM modulate cell population expansion in response to amyloid deposition and rapidly respond to environmental cues

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An expanded subventricular zone supports postnatal cortical interneuron migration in gyrencephalic brains - Nature Neuroscience Neonatal gyrated brains harbor an elaborate subventricular zone, termed the Arc, supporting cortical migratory streams of diverse interneurons.

Neonatal gyrencephalic brains, including humans, harbor an elaborate subventricular zone (the Arc). It contains diverse interneurons from the medial and caudal ganglionic eminences that migrate into the cortex

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Intersectin and endophilin condensates prime synaptic vesicles for release site replenishment - Nature Neuroscience Time-resolved electron microscopy reveals that intersectin-1 and endophilin A1 condensates hold replacement synaptic vesicles close to release sites. Without this, replacement vesicles are unavailable...

Intersectin and endophilin condensates prime synaptic vesicles for release site replenishment

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Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice - Nature Neuroscience Unlike cortical progenitors, ventral telencephalic progenitors retain the ability to generate diverse neuron types during neurogenesis. Here, the authors show that ventral telencephalic progenitor mat...

Ventral telencephalic progenitor maturation is gated by developmental timing, revealing a distinct regulatory logic underlying the development of inhibitory neurons

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Nature Neuroscience July cover. The cover shows fourth ventricle choroid plexus from a mouse at embryonic day 16.5, stained for the water channel AQP1

Our July issue is now live!

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Human thalamocortical structural connectivity develops in line with a hierarchical axis of cortical plasticity - Nature Neuroscience Sydnor et al. developed a new tractography atlas of thalamocortical structural connections and applied it to three youth samples. They uncovered coordinated development between thalamic connectivity a...

Human thalamocortical connectivity matures along the cortex’s sensorimotor–association axis

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Comment: The brain works at more than 10 bits per second

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Just a reminder about our job opening for someone with cellular/molecular neuroscience experience! The application is due July 8.

Addressing artifactual bias in large, automated MRI analyses of brain development - Nature Neuroscience As large-scale neurodevelopmental MRI studies gain prominence, the authors identify tradeoffs between sample size and quality control that can dramatically affect results, and they evaluate a range of...

As large-scale neurodevelopmental MRI studies gain prominence, the authors identify trade-offs between sample size and quality control that can dramatically affect results, and evaluate a range of approaches to mitigate risk for error

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Human CLOCK enhances neocortical function - Nature Neuroscience Regulation of gene expression is a facet of human brain specialization. Here, the authors show that human-like expression of the CLOCK gene in the mouse neocortex enhances cognitive flexibility and ne...

Human-like expression of the CLOCK gene in mouse neocortex enhances cognitive flexibility and neural connectivity, suggesting an evolutionary gain of function in neocortical development that may have contributed to human cognitive specialization

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Changing genes, cells and networks to reprogram the brain after stroke - Nature Neuroscience This review explores how stroke induces changes in gene expression, cell behavior and brain networks, offering insights into recovery. It highlights strategies to enhance cellular reprogramming and br...

A Review on changing genes, cells and networks to reprogram the brain after stroke

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Fine-mapping genomic loci refines bipolar disorder risk genes - Nature Neuroscience This study used fine-mapping to analyze genetic regions associated with bipolar disorder, identifying specific risk genes and providing new insights into the biology of the condition that may guide fu...

Fine-mapping genomic loci refines bipolar disorder risk genes

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Closed-loop electrical stimulation prevents focal epilepsy progression and long-term memory impairment - Nature Neuroscience Pathological neural communication drives the spread of the epileptic network and contributes to memory impairment in focal epilepsy. The authors show that closed-loop electrical stimulation in rodents...

Pathologic hippocampal-cortical communication drives spread of the epileptic network and contributes to memory impairment in focal epilepsy. Cortical closed-loop electrical stimulation can prevent these interactions and preserve long-term memory.

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Applications are now open for the 2026 Takeda Innovators in Science Award with Nature. Early-career researchers in GI & inflammatory disease, neuroscience or oncology: Win a share of US$400K and earn global recognition. Apply today: go.nature.com/4jBp3oM #Academicsky

Large-scale high-density brain-wide neural recording in nonhuman primates - Nature Neuroscience Neuropixels 1.0 NHP is a 45-mm, high-density silicon probe capable of recording large numbers of neurons with single-neuron resolution from most areas in a macaque’s brain.

Neuropixels 1.0 NHP: a 45 mm, high-density silicon probe capable of recording large numbers of neurons with single-neuron resolution from most areas in a macaque’s brain

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