Siân Owen

Deltaviruses spread through a viral Trojan Horse Hepatitis D-like satellite viruses, known as deltaviruses, have been recently discovered in a wide range of animals. These viruses are thought to expr…

We found a viral Trojan Horse: a virus can hide inside another virus.This one surprised us: deltaviruses don’t just borrow a helper virus. They can travel inside it.
A literal Trojan Horse “virus-in-a-virus” route into cells. 🤯 Kudos to 1st author @viroscope.bsky.social and co-authors !

With Eugene Koonin, we propose a concept of “the selfish ribosome”, under which evolution of life is viewed as a ribosomal takeover, where the ribosome evolved to consume most of the cell’s resources, while other cellular componentry ensures the propagation of the ribosome. arxiv.org/abs/2602.23268

High-throughput analyses of a reconstituted diversity-generating retroelement identify intrinsic and extrinsic determinants of diversification Author summary Our study focuses on Diversity-Generating Retroelements (DGRs), a biological “evolution engine” that microbes and viruses use to rapidly develop new functions within specific genes. DGR...

Published version of our work on diversity-generating retroelements!

We reconstituted a phage DGR in E. coli and deployed high-throughput methods to identify factors influencing the activity of this system. #microsky

journals.plos.org/plosgenetics...

We’re hiring a Microscopy Core Director at the Wadsworth Center!
It's a state position (job stability & PENSION!) in a uniquely academic, research-driven environment 😎
Please share 🙏
statejobs.ny.gov/public/vacan...

We’re hiring a Microscopy Core Director at the Wadsworth Center!
It's a state position (job stability & PENSION!) in a uniquely academic, research-driven environment 😎
Please share 🙏
statejobs.ny.gov/public/vacan...

Excited to share a preprint of work from my postdoc with @paulturnerlab.bsky.social exploring how prophages can impact host thermal ecology and evolution. www.biorxiv.org/content/10.6...

Spatial structure: shaping the ecology and evolution of microbial communities Spatial structure naturally emerges in microbial communities, shaping growth, interactions, and evolution, and revealing how microscale processes scale up

Most microbes don't live in shaking flasks; spatial structure shapes how microbes interact and evolve at every scale, as we discuss in our recent review @jeroenmeijer.bsky.social @simonvanvliet.bsky.social @bedutilh.bsky.social @bramvandijk.bsky.social and others
academic.oup.com/femsre/artic... 🧵👇

Happy 125th birthday to the Wadsworth Center, and New York State Department of Health! Established on this day in 1901, just 17 years after the publication of Koch's postulates

T4P vs T4SS pili has to be one of the best (worst?) examples of confusing nomenclature in science! I have had to awkwardly correct even very established microbiologists.
I hugely enjoyed this T4P thread 🤩

🧵 After years out of the field, I and my lab are again working on bacterial type IV pili. We have just posted our first preprints, and I'm excited to share what we have discovered.

This shows Neisseria gonorrheae bacteria infecting a human epithelical cell. Here, you can see the pili in red.

1/

The best immunologists on Earth don't have PhDs. They're parasites.

Today's spotlight 🧵(and big inspo for @ dittobio): ticks!

And if you like this, stay tuned because we will be sharing cool parasite facts each week #TickTalk

The moment you’ve all been waiting for…

🦠 SAVE THE DATE! 🦠

BBM2026 will be held from June 22nd - 23rd at Boston University’s George Sherman Union. Our featured speaker this year is Dr. Eric Skaar from Vanderbilt University!

Registration opens soon!

More info at: bostonbacterial.org

#BBM2026

Postdoctoral position - Synthetic Biology / Bacterial Immunity - Research The Bikard lab at Institut Pasteur in Paris is seeking to hire postdoctoral researchers. We are investigating bacteria / bacteriophages interactions, and the genetic innovation that happens at this in...

🚨 Hiring Alert! 🚨My lab at Institut Pasteur is recruiting several Postdocs! We have exciting open projects in: 🦠 Synthetic Biology and🛡️ Bacterial Immunity. Come do great science with us in the middle of Paris! 🇫🇷🥐 research.pasteur.fr/en/job/postd...

Plasmid mutation rates scale with copy number | PNAS Plasmids are extrachromosomal DNA molecules that spread by horizontal transfer and shape bacterial evolution. Plasmids are typically present at mul...

New paper out in PNAS!!! 🎉

Do more plasmid copies mean faster evolution?

🧵 Dive into the story

www.pnas.org/doi/10.1073/...

Please help spread the word about this tremendous undergraduate research opportunity taking place in Albany this summer!

www.albany.edu/rna/reu-in-rna

What's larger, a protein or its templating mRNA ?

> The mRNA is much larger.

⬛ 𝐀 𝐬𝐞𝐧𝐬𝐞 𝐨𝐟 𝐬𝐜𝐚𝐥𝐞 -- 𝐪𝐮𝐚𝐧𝐭𝐢𝐭𝐚𝐭𝐢𝐯𝐞 𝐢𝐧𝐭𝐮𝐢𝐭𝐢𝐨𝐧 & 𝐜𝐨𝐧𝐬𝐭𝐫𝐚𝐢𝐧𝐭𝐬 -- 𝐢𝐬 𝐚 𝐩𝐨𝐰𝐞𝐫𝐟𝐮𝐥 𝐞𝐧𝐚𝐛𝐥𝐞𝐫 𝐨𝐟 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡.

The figure shows myoglobin protein drawn to scale next to its mRNA template. The coding sequence of an mRNA ...

Super cool Manuel!!

Bacteria chromosomes contain Genomic Islands that provide virulence, antibiotic resistance, MGE-defence,... They transfer between cells, but the mechanism of most remains elusive.

Here we explore the conjugative capacity of these mysterious Genomic Islands.

www.biorxiv.org/content/10.6...

Provirus induction diversifies adaptive variation in Pseudomonas aeruginosa lysogen populations Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that forms chronic infections in people with cystic fibrosis. Often P. aeruginosa strains are lysogens, infected with proviruses, that ...

Happy new year! The second big project of my PhD in Rachel Whitaker's lab is now up! 🎉 We look at how provirus infection affects the evolution of the bacterial chromosome with different types of viral induction – with CRISPRs or antibiotics. Take a peek 🦠 www.biorxiv.org/content/10.6...

🎉 New year, NEW PREPRINT!

Bacteria exhibit astonishing genetic diversity, but where do new genes come from?

My best friend Arya Kaul (/labmate in the @baym lab) investigates how advantageous deletions can spawn new genes - "deletion-born fusions." 🧵:

Really cool work!!

Pili are essential for conjugation also in many Gram-positive bacteria Type IV secretion systems (T4SS) enable the spread of antibiotic resistance and other virulence factors. In Gram-positive bacteria, T4SSs have long been thought to lack VirB2-like proteins that form c...

📣New preprint with @rberntsson.bsky.social👇We overturn the long-standing view that Gram-positive bacteria lack conjugative pili! We identify pili-forming proteins in a wide range of bacteria and show they're essential for the spread of #antibioticresistance #AMR 🧵1/6
www.biorxiv.org/content/10.6...

How medically important antimicrobials bind to the 30S ribosomal subunit in a bacterial pathogen Ribosomes translate the genetic code in mRNA to synthesize proteins in all living organisms. Decoding of mRNA occurs in the small subunit of the ribosome and is mediated by tRNA anticodons. Regions ne...

1/ Our new preprint is out on biorxiv on how antibiotics bind to bacterial 30S subunits, please repost. #ribosome #antibiotics #microsky #rnasky doi.org/10.64898/202...

#microsky #phagesky

Bacterial conjugation can restructure biofilms and increase their resilience while constraining host cell dispersal Winans et al. show how plasmid transfer can reorganize bacterial communities into dense aggregates, conferring antibiotic and phage tolerance to otherwise sensitive host cells. Conjugation-dependent a...

Beautiful work from Jay Winans in the Nadell Lab @dartmouthartsci.bsky.social showing IncF plasmid pED208 spreading like wildfire through E. coli biofilms www.cell.com/current-biol...

Identification of sporulation genes in Bacillus anthracis highlights similarities and significant differences with Bacillus subtilis How good is Bacillus subtilis as a model for the spore-forming pathogen Bacillus anthracis? Using high throughput genetics to identify B. anthracis sporulation genes and cytological analysis of the mu...

Fer’s tour de force in B. anthracis is out! Fer got Tn-seq running, built an ordered knockout library, defined all essential sporulation genes, and found a peptidoglycan deacetylase inhibitor critical for engulfment. Including our first one-by-all Alphafold screen! journals.plos.org/plosbiology/...

Recreation

So impressed by the awesome phage work going on in Western NY! Thanks for the invite @k6logc.bsky.social !! Genius branding

Intracellular interactions shape antiviral resistance outcomes in poliovirus via eco-evolutionary feedback - Nature Ecology & Evolution A model of intrahost poliovirus replication shows that, after several rounds of replication, pocapavir, a poliovirus capsid inhibitor, collapses viral density, preventing intracellular interactions th...

My first lead author paper is out with Ben Kerr and @alisonfeder.bsky.social! We found that making an antiviral too strong can sometimes make resistance easier to evolve. This has implications for how we design drugs, choose doses, and think about viral evolution in the face of treatment. (1/n)

❤️ It's Giving Tuesday: Support ABRCMS 2026 Student Travel Award Fund Fund the Future of Science...

On this #GivingTuesday please consider ABRCMS, one of the most significant and effective conferences to propel scientists toward PhD programs and careers in science.

Support the ABRCMS 2026 Student Travel Award Fund! @asm.org

abrcms.activehosted.com/p_v.php?l=3&...