Danve Castroverde

SALICYLIC ACID SENSOR1 reveals the propagation of an SA hormone surge during plant pathogen advance Salicylic acid (SA) is a key phytohormone that orchestrates immune responses against pathogens, including Pseudomonas syringae bacteria. The timing and extent of SA accumulation are tightly controlled...

SALICYLIC ACID SENSOR1 reveals the propagation of an SA hormone surge during plant pathogen advance

www.science.org/doi/10.1126/...

mRNA initiation and termination are spatially coordinated Transcriptional initiation and termination decisions drive messenger RNA (mRNA) isoform diversity but the relationship between them remains poorly understood. By systematically profiling joint usage o...

mRNA initiation and termination are spatially coordinated

www.science.org/doi/10.1126/...

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In 2026, #PlantBio2026 is headed to Ottawa, Canada’s capital city!

Known for its vibrant culture, walkable downtown, and summer beauty, it’s the perfect backdrop for plant science at its finest. 🌿

📅 Mark your calendars: July 18–22, 2026

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Specific phosphorylation at Ser60 in N terminus of SlCAK1 propels bacterial cold shock protein-induced immunity in Solanaceae plants Plants perceive microbe-derived molecular patterns to initiate the innate immune system. The csp22 peptide, derived from bacterial cold shock protein,…

Specific phosphorylation at Ser60 in N terminus of SlCAK1 propels bacterial cold shock protein-induced immunity in Solanaceae plants

www.sciencedirect.com/science/arti...

The 2025 #CSPB_ERM conference website is now ONLINE!
LINK: event.fourwaves.com/erm2025

Early registration: Oct. 24
Regular registration: Oct. 25-Nov. 12
Abstract deadline for oral/poster presentations: Oct. 24

Student/postdoc registration fees are heavily discounted. See you soon!

image promoting the paper representing a field, the pathogen and computer predicting proteins

Our @elife.bsky.social Version of Record is now out 🎉 : elifesciences.org/articles/105...

Congratulations to @sohambio.bsky.social , @asimjaved.bsky.social , and @jiaxuwu.bsky.social on this beautiful work. We also wrote an easy-to-read eLife Digest for a general audience 👏

Please join us this Friday @ 2:30 for the next #LaurierBiology seminar given by Dr. Tomas DeFalco from @westernu.ca! All welcome! DM for #Zoominar link!

A nucleoporin-associated signaling cascade controls plant immunity via histone modification - Genome Biology Background Plants undergo massive transcriptional reprogramming upon pathogen infection. The transcription factors SAR DEFICIENT1 (SARD1) and CAM-BINDING PROTEIN 60-LIKE G (CBP60g) are master regulators of this process. However, the regulation of SARD1 and CBP60g transcription remains unclear. Results We discover a signaling complex centered on the plant-specific nucleoporins CONSTITUTIVE EXPRESSION OF PR GENES 5 (CPR5) and GUANYLATE-BINDING PROTEIN-LIKE GTPASE 3 (GBPL3), which critically regulates SARD1 and CBP60g transcription. We establish that the RNA processing complexes NineTeen Complex (NTC) and CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR (CPSF) act downstream of CPR5 to activate immunity. A genetic screen identifies GBPL3 and key histone modification complex components as suppressors of the autoimmune phenotype in cpr5 mutants, functioning downstream of NTC/CPSF. Transcriptomic and genetic analyses demonstrate that SARD1 and CBP60g are fully responsible for autoimmune activation in cpr5. Crucially, GBPL3 and the histone modifiers physically interact, bind directly to the SARD1 and CBP60g loci, and repress their expression. Pathogen infection substantially reduces this binding. Consistently, the active histone mark H3K4me3 at SARD1 and CBP60g is modulated by the CPR5-NTC/CPSF-GBPL3/histone modifiers cascade and accumulates significantly upon pathogen infection. Conclusions Our findings reveal a CPR5-NTC/CPSF-GBPL3/histone modifiers signaling cascade that controls the transcription of the SARD1 and CBP60g via histone modification, thereby modulating the transcriptional reprogramming during plant immune responses.

The NPC-associated CPR5-NTC/CPSF-GBPL3 complex controls histone modification and transcription of the central immune genes CBP60g and SARD1 during pathogen infection!

genomebiology.biomedcentral.com/articles/10....

Mitochondrial ROS trigger interorganellular signaling and prime ER processes to establish enhanced plant immunity Mitochondrial ROS initiate mitochondria-ER association and ROS cascade to prime plant immune responses.

Mitochondrial ROS trigger interorganellular signaling and prime ER processes to establish enhanced plant immunity

www.science.org/doi/10.1126/...

MYB46 integrates cuticle and cell wall remodeling to coordinate drought tolerance and pathogen resistance in Arabidopsis The plant cuticle and cell wall form a dynamic barrier against environmental stresses. While MYB46 is a known regulator of secondary cell wall biosynthesis, its role in cuticle formation and the int...

MYB46 integrates cuticle and cell wall remodeling to coordinate drought tolerance and pathogen resistance in Arabidopsis

nph.onlinelibrary.wiley.com/doi/full/10....

ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated auxin fluxes for root gravitropism In gravistimulated roots, gravity perception in the columella redirects the flow of the plant hormone auxin toward the lower root side, where it inhibits cell elongation for downward root bending. Thi...

It is out! A tandem of two papers showing TMK regulation of PIN-dependent auxin transport www.cell.com/cell/fulltex... (PIN2, Friml lab) and www.cell.com/developmenta... (PIN1, Xu lab)

HY5 integrates light and electrical signaling to trigger a jasmonate burst for nematode defense in tomato - Nature Communications Sun et al. reveal that root-knot nematode attack activates a phyB-HY5 cascade that integrates light and GLR3.5-CaM2 signals to boost JA synthesis in tomato, with HY5 moving from leaves to roots to sustain signaling and trigger JA-mediated defense.

HY5 integrates light and electrical signaling to trigger a jasmonate burst for nematode defense in tomato

www.nature.com/articles/s41...

Cross-kingdom mechanisms of trained immunity in plant systemic acquired resistance - Nature Plants Plants face constant microbial threats and have evolved highly effective inducible immune systems, culminating in systemic acquired resistance. Plant systemic acquired resistance and mammalian trained immunity share striking similarities, which are explored in this Review.

Cross-kingdom mechanisms of trained immunity in plant systemic acquired resistance

www.nature.com/articles/s41...

The pathogen effector BcSSP2 suppresses the NPC phase separation to facilitate Botrytis cinerea infection - Nature Communications Wang et al. reveal that the fungal effector BcSSP2 disrupts protein phase separation at the plant nuclear pore, inhibiting the transport of immune regulators and suppressing host defenses to facilitate pathogen infection.

The pathogen effector BcSSP2 suppresses the NPC phase separation to facilitate Botrytis cinerea infection

www.nature.com/articles/s41...

Biomolecular condensates of ATG18 reshape ER for autophagy in plants Autophagosomes originate from and maintain association with the endoplasmic reticulum (ER) during their formation, yet how these processes are molecul…

Biomolecular condensates of ATG18 reshape ER for autophagy in plants

www.sciencedirect.com/science/arti...

We are honoured to host Dr. Tom DeFalco ( #Western #UWO ) as our Seminar Speaker this Friday (Oct 10th) at 2:30 PM! The seminar will be hybrid (in-person with Zoom). @laurierbiology.bsky.social

Please DM for the link!

Thanks to all our GENEROUS sponsors! @cspbscbv.bsky.social @jxbotany.bsky.social @cp-cellreports.bsky.social @newphyt.bsky.social @laurierbiology.bsky.social @neurosnap.bsky.social @biochambers.bsky.social @cdnsciencepub.com

The 2025 #CSPB_ERM conference website is now ONLINE!
LINK: event.fourwaves.com/erm2025

Early registration: Oct. 24
Regular registration: Oct. 25-Nov. 12
Abstract deadline for oral/poster presentations: Oct. 24

Student/postdoc registration fees are heavily discounted. See you soon!

Engineered geminivirus replicons enable rapid in planta directed evolution Directed evolution can rapidly generate genetic variants with new and enhanced properties, yet efficient platforms for performing such evolution directly in plant cells have been lacking. We developed...

Engineered geminivirus replicons enable rapid in planta directed evolution

www.science.org/doi/10.1126/...

ATP-dependent remodeling of chromatin condensates reveals distinct mesoscale outcomes Adenosine triphosphate (ATP)–dependent chromatin remodeling enzymes mobilize nucleosomes, but how such mobilization affects chromatin condensation is unclear. We investigate effects of two major remod...

ATP-dependent remodeling of chromatin condensates reveals distinct mesoscale outcomes

www.science.org/doi/10.1126/...

Cellular energy sensor SnRK1 suppresses salicylic acid-dependent and -independent defenses and bacterial resistance in Arabidopsis In nature, plants cope with various pathogens that compete for cellular resources during infection. It has long been suggested that plant defense activity must be linked to cellular energy and metabol...

Cellular energy sensor SnRK1 suppresses salicylic acid-dependent and -independent defenses and bacterial resistance in Arabidopsis

www.biorxiv.org/content/10.1...

Plant trait variation shapes plant–microbe interactions in changing climate As the climate crisis intensifies, finding strategies to mitigate its cascading effects is now a pressing global priority for both scientists and poli…

Plant trait variation shapes plant–microbe interactions in changing climate

Excellent review from the Jong Hum Kim Lab (#POSTECH)!

www.sciencedirect.com/science/arti...

Genomic atlas of 8,105 accessions reveals stepwise domestication, global dissemination, and improvement trajectories in soybean A genome-wide analysis of 8,105 soybean accessions reveals its stepwise domestication process, in which black soybean acts as an evolutionary intermediate, and identifies region- and era-specific sele...

Genomic atlas of 8,105 accessions reveals stepwise domestication, global dissemination, and improvement trajectories in soybean

www.cell.com/cell/fulltex...

The Panoptes system uses decoy cyclic nucleotides to defend against phage - Nature The Panoptes antiphage system defends bacteria by detecting phage-encoded counter-defences that sequester cyclic nucleotide signals, triggering membrane disruption and highlighting a broader strategy of sensing immune evasion through second-messenger surveillance.

The Panoptes system uses decoy cyclic nucleotides to defend against phage

www.nature.com/articles/s41...

A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling - Nature Panoptes, an anti-phage defence system against virus-mediated immune suppression, is revealed.

A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling

www.nature.com/articles/s41...

Connecting chemical and protein sequence space to predict biocatalytic reactions - Nature A two-phase machine-learning-based tool making use of high-throughput experimentation is introduced to examine the connections between chemical and protein sequence space and predict productive biocatalytic reactions among substrate and enzyme pairs.

Connecting chemical and protein sequence space to predict biocatalytic reactions

www.nature.com/articles/s41...

Too hot to defend: elevated temperature compromises systemic acquired resistance Click on the article title to read more.

Thank you very much to Editor Martin Balcerowicz (@transcription.bsky.social) for highlighting our work in the September issue of @theplantjournal.bsky.social!

Article: doi.org/10.1111/tpj....
Research Highlight: doi.org/10.1111/tpj....

@laurierbiology.bsky.social @cspbscbv.bsky.social

Photorespiration and plant immunity: Interactions and implications under a changing climate Climate change has profound impacts on plant growth, productivity, and immunity. Photosynthesis, a key biological process that sequesters atmospheric …

Photorespiration and plant immunity: Interactions and implications under a changing climate

www.sciencedirect.com/science/arti...

The polymerase-associated factor 1 complex modulates the growth-defense tradeoff in Arabidopsis The salicylic acid receptor NPR1 mediates the degradation of PAF1, which interacts with HDACs to repress defense gene expression.

The polymerase-associated factor 1 complex modulates the growth-defense tradeoff in Arabidopsis

www.science.org/doi/10.1126/...

Salicylic acid inhibits V-ATPase activity and restricts cell elongation The phytohormone salicylic acid directly inhibits V-ATPase activity and cell elongation thereby limiting plant growth.

Salicylic acid inhibits V-ATPase activity and restricts cell elongation

academic.oup.com/plphys/advan...