Danve Castroverde

Congratulations to all authors, especially co-first authors Alyssa and Lingya! 👏👏👏

This research was funded by #NSERC, #CFI, #ORF and #Laurier.

onlinelibrary.wiley.com/doi/10.1111/...

Warm temperature suppresses plant systemic acquired resistance by intercepting N‐hydroxypipecolic acid biosynthesis Elevated temperature impacts plant immunity at the primary infection site, but how it affects immune preparedness for future infections remains unclear. Here we report that warm temperature suppresse...

Today we report how plant immune preparedness against future infections is negatively intercepted by elevated temperatures! @theplantjournal.bsky.social #OpenAccess

This work was initiated by my first MSc student Alyssa Shields. @laurierbiology.bsky.social

onlinelibrary.wiley.com/doi/10.1111/...

Synthesis of large single-transcript pathways from oligonucleotide pools: Design of STARBURST, an autobioluminescent reporter | PNAS

www.pnas.org/doi/10.1073/...

Plasma membrane CYBDOM proteins catalyse apoplastic AsA regeneration and interact with RbohD to activate autophagy and drought tolerance in plants - Nature Plants This study reveals that CYBDOM proteins promote drought tolerance by regenerating apoplastic ascorbic acid (AsA) and activating autophagy through interaction with RbohD, and link AsA redox, ROS and se...

Plasma membrane CYBDOM proteins catalyse apoplastic AsA regeneration and interact with RbohD to activate autophagy and drought tolerance in plants

www.nature.com/articles/s41...

Pre-mRNA processing factors differentially impact coordination between co-transcriptional cleavage and transcription termination - Nature Communications This study reveals how pre-mRNA processing factors in Arabidopsis distinctly coordinate cleavage and transcription termination, highlighting complex roles of CPSF, CstF, PAPS1, BORDER proteins, and FP...

Pre-mRNA processing factors differentially impact coordination between co-transcriptional cleavage and transcription termination

www.nature.com/articles/s41...

Arabidopsis HSFA1b functions as a heat sensor inhibiting OST1-mediated stomatal closure through its adenylate-cyclase activity Global climatic warming profoundly affects plant communities, but details of mechanisms and the identity of sensors controlling plant thermosensing ar…

Arabidopsis HSFA1b functions as a heat sensor inhibiting OST1-mediated stomatal closure through its adenylate-cyclase activity

www.sciencedirect.com/science/arti...

Temperature-responsive N4-acetylcytidine mRNA modification controls thermosensory flowering in Arabidopsis Wu and Zhang et al. report that ac4C mRNA modification catalyzed by two Arabidopsis writers, NAT10A/B, undergoes dynamic regulation in response to low ambient temperature. NAT10s promote temperature-r...

Temperature-responsive N4-acetylcytidine mRNA modification controls thermosensory flowering in Arabidopsis

www.cell.com/developmenta...

GA-independent DELLA regulation by inositol pyrophosphate in a nonvascular land plant - Nature Chemical Biology A noncanonical pathway of DELLA regulation by a conserved inositol pyrophosphate synthase was identified in the liverwort, Marchantia polymorpha, that lacks the canonical gibberellin-induced DELLA deg...

Delighted to share our work "GA-independent DELLA regulation by pyrophosphate in a nonvascular land plant" published now in Nature Chemical Biology! @natchembio.nature.com

www.nature.com/articles/s41...

Pantropical tree rings show small effects of drought on stem growth Increasing drought pressure under anthropogenic climate change may jeopardize the potential of tropical forests to capture carbon in woody biomass and act as a long-term carbon dioxide sink. To evalua...

Pantropical tree rings show small effects of drought on stem growth

www.science.org/doi/10.1126/...

Reverse engineering of the pattern recognition receptor FLS2 reveals key design principles of broader recognition spectra against evading flg22 epitopes - Nature Plants By dissecting natural variants, Zhang et al. uncover design principles for engineering the FLS2 immune receptor with broad recognition spectra to detect evasive bacterial pathogens, offering a promisi...

Reverse engineering of the pattern recognition receptor FLS2 reveals key design principles of broader recognition spectra against evading flg22 epitopes

www.nature.com/articles/s41...

Unlocking expanded flagellin perception through rational receptor engineering - Nature Plants Receptor kinase FLS2 detects the flg22 epitope of bacterial flagellin. Here the authors identify key residues on FLS2’s concave surface that enable expanded perception of flg22 variants, allowing the ...

Unlocking expanded flagellin perception through rational receptor engineering

www.nature.com/articles/s41...

📣 Thermomorphogenesis community 📣
I’m very excited to announce that Danve Castroverde (@danvec.bsky.social) will present his preprint on plant immunity in thermomorphogenesis in our next JC (12 August).
Don't miss out!!

TOC1 supresses PAMP-triggered immunity in Arabidopsis The circadian clock synchronizes plants with the rhythmic changes in their environment created by the cycle of day and night. Plant-pathogen interactions are influenced by this rhythmic cycle and a fu...

TOC1 supresses PAMP-triggered immunity in Arabidopsis

www.biorxiv.org/content/10.1...

JIC GROUP LEADER VACANCY

We're looking for interests in areas including, but not limited to, growth and development, environmental and organism interactions, physiology, signalling and molecular processes, taking quantitative cell biological, genetic, biochemical and modelling approaches.

Really nice work showing the hormone responses to elevated temperature in tomato! Some similarities and differences compared to Arabidopsis - it will be interesting to untangle the species-specific regulation!

Thanks, Hannah! We plan to eventually explore these in detail with multiple temperatures, elicitors and timepoints!

Impact of elevated temperature on immunity-related hormone signaling in tomato plants Molecular mechanisms governing the plant-pathogen-environment "disease triangle" are starting to emerge, although less so in agriculturally important species like tomato (Solanum lycopersicum). Here w...

Happy to share this short preprint (micropublication) based in part on former BSc student Karen Liu's honours thesis project! @laurierbiology.bsky.social @biorxivpreprint.bsky.social @biorxiv-plants.bsky.social

www.biorxiv.org/content/10.1...

Exciting breakthroughs! 👏😻😱

Deciphering phenylalanine-derived salicylic acid biosynthesis in plants - Nature Diverse plant species synthesize salicylic acid from phenylalanine through a pathway that includes a conserved triple-enzyme module that converts benzoyl-CoA to salicylic acid.

Deciphering phenylalanine-derived salicylic acid biosynthesis in plants

www.nature.com/articles/s41...

Complete biosynthesis of salicylic acid from phenylalanine in plants - Nature Characterization of four SALICYLIC ACID-DEFICIENT GENEs in rice identifies an ancestral pathway for biosynthesis of salicylic acid from phenylalanine and provides genetic targets for engineering disea...

Complete biosynthesis of salicylic acid from phenylalanine in plants

www.nature.com/articles/s41...

Three-step biosynthesis of salicylic acid from benzoyl-CoA in plants - Nature The salicylic acid (SA) biosynthesis pathway—involving ligation of benzoyl coenzyme A and benzyl alcohol to give benzyl benzoate; hydroxylation of benzyl benzoate to give benzyl salicylate; and cleava...

Three-step biosynthesis of salicylic acid from benzoyl-CoA in plants

www.nature.com/articles/s41...

A root-based N-hydroxypipecolic acid standby circuit to direct immunity and growth of Arabidopsis shoots - Nature Plants Root microorganisms can trigger the release of immune-stimulating N-hydroxypipecolic acid from Arabidopsis roots by manipulating a standby circuit of its continuous synthesis and immobilization. N-hyd...

A root-based N-hydroxypipecolic acid standby circuit to direct immunity and growth of Arabidopsis shoots www.nature.com/articles/s41...

“Our study provides strong evidence that the IC pathway emerged within the Brassicales order, which was driven by key evolutionary innovations in the IC pathway genes ICS, EDS5, and PBS3.”

Emergence of isochorismate-based salicylic acid biosynthesis within Brassicales www.pnas.org/doi/10.1073/...

Cis-regulatory variation in ISOCHORISMATE SYNTHASE 1 modulates systemic salicylic acid biosynthesis and systemic acquired resistance in plants Systemic acquired resistance (SAR) is a long-distance immune response that protects uninfected plant tissues following a localized pathogen attack. In the model plant Arabidopsis thaliana , SAR depend...

Cis-regulatory variation in ISOCHORISMATE SYNTHASE 1 modulates systemic salicylic acid biosynthesis and systemic acquired resistance in plants

www.biorxiv.org/content/10.1...

Histone deacetylase complex 1 facilitates hypocotyl elongation by attenuating acetylation and transcription via a PIF4-dependent process Photomorphogenesis is a transitional response occurring when seedlings are exposed to light. Upon red-light exposure, this process depends on the nucl…

Histone deacetylase complex 1 facilitates hypocotyl elongation by attenuating acetylation and transcription via a PIF4-dependent process

www.sciencedirect.com/science/arti...

Structural determinants of DANGEROUS MIX 3, an alpha/beta hydrolase that triggers NLR-mediated genetic incompatibility in plants Wan, Kim, et al. provide cryo-EM structures of DANGEROUS MIX 3 (DM3) metabolic enzyme complexes from two Arabidopsis natural accessions, revealing an immune switch. Compromised DM3 dimer interface integrity triggers DM2h NLR activation and immune signaling in plants. This work suggests that enzyme complex surveillance leads to immune conflict in plants, resulting in autoimmune responses in hybrids.

Structural determinants of DANGEROUS MIX 3, an alpha/beta hydrolase that triggers NLR-mediated genetic incompatibility in plants

Functional regimes define soil microbiome response to environmental change - Nature Experimental perturbation of soil pH leads to a generalizable model of the soil microcosm comprising three functional regimes with distinct mechanisms linking environmental change to metabolite dynami...

Functional regimes define soil microbiome response to environmental change

www.nature.com/articles/s41...

Remodelling autoactive NLRs for broad-spectrum immunity in plants - Nature Cleavage by pathogen-derived proteases of an engineered chimeric protein activates its plant immune receptor component, enabling broad-spectrum resistance to pathogens in plants.

Remodelling autoactive NLRs for broad-spectrum immunity in plants

www.nature.com/articles/s41...

Coordinated control of calcium signaling by CPK3 and CaM2 via CNGCs in response to cold stress in Arabidopsis Calcium (Ca2+) signaling plays a pivotal role in cellular responses to cold stress. Exposure of plant cells to cold water triggers cytosolic Ca2+ elev…

Coordinated control of calcium signaling by CPK3 and CaM2 via CNGCs in response to cold stress in Arabidopsis @cellpress.bsky.social #DevCell

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Endophytic commensal bacteria capitalize on the AvrPto-FER pathway to enhance proliferation during early stages of pathogen invasion Abstract. Leaves typically harbor a community of pre-existing beneficial and commensal bacteria that contribute to plant health. When pathogens invade, pla

Endophytic commensal bacteria capitalize on the AvrPto-FER pathway to enhance proliferation during early stages of pathogen invasion @isme-microbes.bsky.social

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