Danve Castroverde

Transcriptomic biomarkers reveal jasmonic and salicylic acid state under field herbivory

www.biorxiv.org/content/10.1...

A small polymerase ribozyme that can synthesize itself and its complementary strand The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

A small polymerase ribozyme that can synthesize itself and its complementary strand | Science www.science.org/doi/10.1126/...

Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate Polyamines are often associated with ribosomes and are thought to stabilize their integrity. In Arabidopsis, the polyamine thermospermine (tSpm) affects xylem cell fate. tSpm induces translation of SU...

Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate | Science www.science.org/doi/10.1126/...

Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation Transcriptional adaptation (TA) is a genetic robustness mechanism through which mutant messenger RNA (mRNA) decay induces sequence-dependent up-regulation of so-called adapting genes. How cytoplasmica...

Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation | Science www.science.org/doi/10.1126/...

Dihydroxyhexanoic acid biosynthesis controls turgor in pathogenic fungi Many plant pathogenic fungi penetrate host surfaces mechanically, using turgor pressure generated by specialized infection cells called appressoria. These appressoria develop semipermeable cell walls ...

Dihydroxyhexanoic acid biosynthesis controls turgor in pathogenic fungi | Science www.science.org/doi/10.1126/...

We are excited to host Dr. Allyson MacLean (@uottawa.ca) on Tuesday (Feb 24th)!

She will be delivering this year's @laurierbiology.bsky.social IDEA Seminar.

Please DM for the Zoom registration link! Hope to see you there. @wilfridlaurieruni.bsky.social

WUSCHEL modulates jasmonate signaling to control the balance between growth and defense in the shoot apical meristem https://www.biorxiv.org/content/10.64898/2026.02.10.705072v1

Ubiquitin recognition integrates plant immune signaling by cell-surface and intracellular receptors www.biorxiv.org/content/10.6...

Structural basis of canonical TIR-NLR activation in plant innate immunity

www.biorxiv.org/content/10.6...

Out now in @natureportfolio.nature.com: PARM reveals gene regulation is far more predictable than thought. Lightweight, cell‑type specific, and experimentally validated. Enables functional prediction of regulatory mutations with just one dish of cells + one day of compute.
➡️ doi.org/10.1038/s415...

New Article! Designing and testing CRISPRi-based synthetic gene circuits in plants

Leaf it to science: Uncovering plant immune systems through technological advances (Xinnian Dong) doi.org/10.1093/plph... #PlantScience @aspbofficial

Pseudomonas volatiles shape the root transcriptome and microbiome to promote plant growth under drought

www.biorxiv.org/content/10.6...

The immunity-associated protein ACIP1 counteracts MIDD1 to coordinate xylem cell wall patterning Cell wall patterning plays a crucial role in determining the function of plant cells.1 Protoxylem and metaxylem vessel cells form striped and pitted c…

The immunity-associated protein ACIP1 counteracts MIDD1 to coordinate xylem cell wall patterning

www.sciencedirect.com/science/arti...

Circadian regulation of sunflower heliotropism, floral orientation, and pollinator visits Sun-tracking when young, east-facing when mature, warmer sunflowers attract more pollinators.

This lesson was inspired by this exciting 2016 heliotropism study from the Stacey Harmer Lab: science.org/doi/10.1126/...

E-book available here: store.macmillanlearning.com/ca/product/P...

Congratulations to Diane and Emily for publishing "Pathways to Scientific Teaching vol. 2!" @macmillanusa.bsky.social

Thanks for the opportunity to contribute Lesson 2 on
plant hormone-mediated growth! 🌱🌱🌱

@laurierbiology.bsky.social @wilfridlaurieruni.bsky.social

Blue light can induce SAR in npr1 mutants! 🙀🌱🦠

www.biorxiv.org/content/10.6...

Aging drives a program of DNA methylation decay in plant organs Plants display a wide range of life spans and aging rates. Although dynamic changes to DNA methylation are a hallmark of aging in mammals, it is unclear whether similar molecular signatures reflect ra...

Aging drives a program of DNA methylation decay in plant organs

www.science.org/doi/10.1126/...

Multiple protein structure alignment at scale with FoldMason Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...

Multiple protein structure alignment at scale with FoldMason

www.science.org/doi/10.1126/...

A benchmark of expert-level academic questions to assess AI capabilities - Nature Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Nature research paper: A benchmark of expert-level academic questions to assess AI capabilities

go.nature.com/45zkozH

Advancing regulatory variant effect prediction with AlphaGenome - Nature AlphaGenome, a deep learning model that inputs 1-Mb DNA sequence to predict functional genomic tracks at single-base resolution across diverse modalities, outperforms existing models in variant effect...

Can we have one for plants please?! 😍🌱

Advancing regulatory variant effect prediction with AlphaGenome: www.nature.com/articles/s41...

Advancing regulatory variant effect prediction with AlphaGenome - Nature AlphaGenome, a deep learning model that inputs 1-Mb DNA sequence to predict functional genomic tracks at single-base resolution across diverse modalities, outperforms existing models in variant effect prediction and enables comprehensive genomic analysis.

Our breakthrough AI model AlphaGenome is helping scientists understand our DNA, predict the molecular impact of genetic changes, and drive new biological discoveries. 🧬

Find out more in https://xcancel.com/Nature ↓ 🔗↗️
https://goo.gle/4bXlV6y

Our new paper is out in @nature.com

"Pesticide residues alter taxonomic and functional biodiversity in soils"

Largest in field assessmnt of pesticide effects on soil life🧬🇪🇺🦠🍄

www.nature.com/articles/s41...

@scienceinnovation.ec.europa.eu @panospanagos.bsky.social @mvanderheijden.bsky.social

"This One Piece was not made with just one piece."

Love the annual #LEGO analogy & showcase when discussing cytoskeletal systems in #BI236 (Cell Biology class)!

@laurierbiology.bsky.social @wilfridlaurieruni.bsky.social

An uORF-encoded mobile peptide sparks systemic stomatal immunity In Arabidopsis, the uORF-encoded long-distance mobile peptide USIC in pathogen-infected local leaves activates systemic stomatal immunity, leading to stomatal closure in uninfected distal leaves.

An uORF-encoded mobile peptide sparks systemic stomatal immunity

www.cell.com/cell/fulltex...

PDLP5 regulates aquaporin-mediated hydrogen peroxide transport in Arabidopsis

www.biorxiv.org/content/10.6...

The Effector RipAW Enhances Ralstonia solanacearum Invasion in Arabidopsis via CBP60g/SARD1‐Dependent and ‐Independent Pathways The effector RipAW facilitates R. solanacearum infection by suppressing CBP60g/SARD1-dependent SA pathway and triggering CBP60g/SARD1-independent root architecture changes.

The Effector RipAW Enhances Ralstonia solanacearum Invasion in Arabidopsis via CBP60g/SARD1‐Dependent and ‐Independent Pathways

bsppjournals.onlinelibrary.wiley.com/doi/10.1111/...

Developmental and abiotic stress assays in Columbia-0 (Col-0) and mutants (abi1-1 and defenseless).

Decoding plant defense signaling using the defenseless mutant

Baral and Brosché

nph.onlinelibrary.wiley.com/doi/10.1111/...

Chromatin remodeling at the C-REPEAT BINDING FACTOR cluster controls growth retardation at low ambient temperature Plants adapt to low ambient temperatures using a temperature-sensitive control system that remodels chromatin to control growth.

Chromatin remodeling at the C-REPEAT BINDING FACTOR cluster controls growth retardation at low ambient temperature

academic.oup.com/plcell/advan...

Chromatin state architecture governs transcription factor accessibility across plant genomes Author summary In eukaryotes, DNA is tightly associated with histone proteins. Histone covalent modifications and histones isoforms, also called histone variants provide most of the complexity of chro...

This is a very special paper for me. I had the idea of combining transcription factor binding with chromatin in 2016/8. It took some time, but thanks to Fred and Vikas, we can finally share the story in @plos.org Genetics looking at chromatin states in Arabidopsis and Marchantia. #PlantScience