Matrix viscoelasticity regulates dermal fibroblast activation in a three-dimensional fibrillar microenvironment https://www.biorxiv.org/content/10.64898/2026.03.02.709111v1
Puumala orthohantavirus dysregulates hyaluronan metabolism in lung cells and correlates with disease severity and lung impairment https://www.medrxiv.org/content/10.64898/2026.03.10.26348053v1
This is Summit. He is a friend to pretty much everyone he meets. But has a special soft spot for the little critters who stop long enough for him to say hello. 13/10 (IG: bakerbarnes)
They study rejected tissue, areas of fibrosis overlapped almost exactly with the lymphatic vasculature - evidence that the fibrosis is driven by a damaging build-up of hyaluronan.
medicine.washu.edu/news/surpris...
🌳 Do you want to contribute to research on how humans perceive forests? Take this quick, anonymous 10-min survey 🌲
👉 www.biodiful.org#/forest
This will help us explore how people experience forest biodiversity!
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ECM swelling pressure driving morphogenesis. Tumours can also accumulate high HA and cause pressure, I wonder how general this mechanism is across tissues.
pubmed.ncbi.nlm.nih.gov/34942099/
"Hyaluronan enriched transfer medium was associated with significantly higher live birth rates compared with standard medium."
Research led by Tomasz Nowakowski, PhD @ucsanfrancisco.bsky.social @ucsfstemcell.bsky.social in @nature.com | New map of fetal brain cell development may change our understanding of mental illness and cancer www.earth.com/news/new-map... #UCSFProud
(2) sufficient HA production for early signaling, but insufficient long chain HMW-HA to promote anti-inflammatory resolution in later healing?
I guess that’s why hydrogels work so well, they externally restore hydration, you can’t see an internal wound tho!
Could dysfunctional glycolysis and hexosamine biosynthetic pathway flux create two different failure modes in wound healing or ischemic tissue repair?
(1) Insufficient total hyaluronan production to properly support early inflammatory and angiogenic signaling.
Do I detect shame in his eyes? Heggy cracking like an eggy
Update4.
Included the idea that HAS2 may have requirements for chain building.
I realise its quite ambitious and speculative, but there are testable parts to it.
Some more potential titles:
The Naked Homo Hypothesis
The Tree-to-Tunnel Transition
The Wrinkle Rat's Secret
osf.io/sd5g4/wiki?w...
there's so much bad in the world but there's also people who lift up and carry an elderly bat around every day so he can pretend he's flying again, and that's the part of the world I think is worth fighting for
I think this may be the only paper reporting perineuronal nets in naked mole-rats.
Would the authors have noted if the nets themselves were structurally different? They report aggrecan staining but minimal WFA in some regions.
pubmed.ncbi.nlm.nih.gov/29277975/
Oxytocin is typically described as a "social" hormone. In our new article, we propose that it should instead be viewed a hormone that modulates behavioral flexibility
doi.org/10.1016/j.ne...
Update3.
Still trying to think of what to call it..
The Soft-in-the-Head Hypothesis
The Jelly Head Model
The Waterworld Hypothesis (great movie)
osf.io/sd5g4/wiki?w...
"A genome-wide CRISPR screen reveals cancer-specific regulators of hyaluronan binding and cellular invasion"
www.researchhub.com/paper/110810...
Wnt signaling in stromal fibroblasts promotes gastric cancer metastasis by increasing hyaluronan production, highlighting new potential targets to disrupt the tumor-supportive microenvironment. doi.org/hbrpbx
A 1996 study measured HA in human CSF:
Controls: ~50–166 µg/L - Elevated with age
Meningitis: >8,000 µg/L
Tumour: > 4,000 µg/L
Would be interesting to know size of HA here, and whether levels differ across various infections and neurological disorders.
pubmed.ncbi.nlm.nih.gov/8899053/
Excited to share our new study using engineered immune proteins to quench inflammation in aged brains!!
Congratulations to Paloma Navarro and the entire team!
Fantastic collaboration with Chris Garcia's lab, Tony Wyss-Coray's lab, and Saul Villeda's lab!
www.cell.com/immunity/ful...
Update3.
Still trying to think of what to call it..
The Soft-in-the-Head Hypothesis
The Jelly Head Model
The Waterworld Hypothesis (great movie)
osf.io/sd5g4/wiki?w...
New paper from the lab led by @ericmulhall.bsky.social addresses how PIEZO1 and PIEZO2 are tuned to different types mechanical forces. From nanometer-scale super-resolution microscopy to in vivo experiments, links single-molecule observations to physiological function.
www.nature.com/articles/s41...
Metabolic shift → ECM change?
Cardiomyocyte hypertrophy co-localizes with accumulation of hyaluronan in cMyBPC+/- mice hearts
www.biorxiv.org/content/10.6...
If I'm the opposite will I make it?
good morning everyone project your personal imposter syndrome onto this gif ur welcome
pity them
What about people who are not US citizens? most of their userbase seems to be non-US. I asked in his AMA, no response..
#ChatGPT
Integrins sense stiffness by pulling on the ECM.
HMW-HA increases hydration and alters matrix viscoelasticity.
Does changing HA content change how much force cells actually “feel”?
It’s time for #moleratmonday, where we bring you a fun fact about the naked mole rat, and it’s also Monday 🐀 Today’s fact:
For a rodent, they have an incredibly long lifespan. It’s estimated to be ~10 years in the wild, and 30+ in captivity! The price: they’re super wrinkly even when they’re young
