Mirko Pegoraro PhD

r/ChatGPTPro u/vurto • 28d If ChatGPT is not consistently dependable, how are we suppose to use it for actual work? Discussion It's behavior and results can randomly change due to some OpenAl tweaking that's opaque. On some days it can't even keep track of a fresh chat, it can't do calculations, it can't sort through a chat to extract relevant information, and when it's suppose to refer to source material in a PDF, it doesn't. All because OpenAl trained it for fluency and basically to simulate whatever it can for user satisfaction. I can use it for general chats, philosophical stuff, therapy, but nothing serious. I'm pro Al, but I approach it with skepticism knowing it's undependable (as I do with anything I read). And prompts can be interpreted/executed differently across users' own interaction with their Als so it's not truly scalable. How does the business world / leaders expect staff to adopt Al if it's not consistently dependable? It doesn't even calculate like a calculator. If the internet start claiming 2+2=5, that's what it'll answer with. I'd use it for hobbies and pet projects but I can't imagine using it for anything "mission critical".

You're so close

From genes to patterns: five key dynamical systems concepts to decode developmental regulatory mechanisms Summary: Dynamical systems theory provides a powerful quantitative and intuitive framework to understand developmental processes. This Primer brings key concepts of this framework to the ever-growing ...

A Summer reading recommendation: new primer in @dev-journal.bsky.social explains how dynamical systems theory unlocks the logic of developmental patterning

Everything from bistable switches & oscillators to phase portraits & more with Python code to explore

journals.biologists.com/dev/article/...

Thrilled to share our work using live imaging to understand how Epiblast (future embryo proper) and Primitive Endoderm (future extraembryonic tissues) cell fates segregate in the preimplantation mouse embryo. Gargantuan effort led by amazing @rpkimyip.bsky.social, David Denberg and Denis Faerberg!

Image of an old building in Oxford with the heading 'postdoc opportunities' and the text 'computational approaches to improve rare disease diagnosis and treatment' and 'Big Data Institute, University of Oxford'

📣 We are recruiting! Please share!!

Are you a bioinformatician / computational scientist who wants to apply your skills to understanding regulatory biology and improving rare disease diagnosis and treatment? 🧠 💻 🧬 🩺

We have two roles available 👇

🧵 1/4

This is moving.

Kamala Harris feels the pain we feel. Not just from her loss, but from the trauma and abuse our country is living through.

What could have been…

Metagenomic estimation of absolute bacterial biomass in the mammalian gut through host-derived read normalization | mSystems In this study, we asked whether normalization by host reads alone was sufficient to estimate absolute bacterial biomass directly from stool metagenomic data, without the need for synthetic spike-ins, ...

You can get an accurate estimate of total bacterial biomass from stool metagenomes by simply normalizing by host read count, without needing any additional measurements.

Excellent work by UW Master's student Gechlang Tang in @asm.org #mSystems Journal.

journals.asm.org/doi/10.1128/...
🧵

The Nassau County legislature on Long Island attempts to silence a young American citizen whose father was abducted by ICE.

If you are applying to a PhD, don't use an LLM in composing your proposal.

If you are doing a PhD, don't use an LLM to do the writing and reading and thinking for you.

Sorry, I am going to die on this hill.

United Farm Workers President Teresa Romero -

Two years ago, we invited all 100 senators to work in the fields. Only two of them accepted: Alex Padilla and Cory Booker.

Second Star to the Right: Essays on Leadership in Star Trek Discover 'Second Star to the Right,' exploring how Star Trek inspires leadership lessons for diverse academic and professional fields.

Now on sale! "Second Star to the Right: Essays on Leadership in Star Trek" explores how Star Trek inspires leadership lessons for diverse academic and professional fields.

I wrote Chapter 5—it's my mentoring philosophy told through the lens of Star Trek: Lower Decks.

Evolution and functioning of an X–A balance sex-determining system in hops - Nature Plants On the basis of the whole-genome sequences of cultivated and wild hops, this study describes the evolution of sex chromosomes, including degeneration and dosage compensation, and identifies a candidat...

www.nature.com/articles/s41...

Trump — emperor of Brazil The US president’s sympathy for disgraced strongman Bolsonaro is part of an alarming pattern

'Rubio’s move qualifies as one of those “pinch me” moments. The former Republican senator built his brand around evangelism for US democratic values and the rule of law. Now he is punishing a sister democracy’s legal system for enforcing the law.'
www.ft.com/content/9a76...

Mitochondrial Donation and Preimplantation Genetic Testing for mtDNA Disease | NEJM Children born to women who carry pathogenic variants in mitochondrial DNA (mtDNA) are at risk for a range of clinical syndromes collectively known as mtDNA disease. Mitochondrial donation by pronuc...

It was wonderful to see the NEJM paper today about healthy babies born free of mtDNA disease following mitochondrial donation. Built on decades of work led by Doug Turnbull and his team in Newcastle.

www.nejm.org/doi/full/10....

Giant study finds a research field that’s mostly reproducible Researchers assessed more than 1,000 results from fruit-fly immunity research published between 1959 and 2011. The majority of findings look verifiable.

Drosophila for the win! When you can afford more than 3 subjects per experiment, your results get more reliable...

www.nature.com/articles/d41...

Associate Professor @lucystats.bsky.social spoke today at the “Character Across the Curriculum” workshop about the importance of curiosity in the era of artificial intelligence — part of @wakeforest.bsky.social Educating Character Initiative and the Program for Leadership and Character

Had a lovely time at the Northern England Developmental Biology meeting on Thursday, and UK Evo Devo on Friday. Great to hear about the fascinating ongoing #DevBio research in the UK and beyond!

Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances - Nature Microbiology Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances (PFAS), commonly known as forever chemicals, in intracellular aggregates. Colonization of gnotobiotic mice with bioaccumulating bac...

Gut bacteria have the ability to accumulate PFAs, and the potential to help facilitate PFA excretion by their host: www.nature.com/articles/s41... #MicroSky

Parents urged to get children vaccinated after measles death in Liverpool Child reportedly died at Alder Hey hospital amid surge of measles cases in city Health officials have urged people to come forward for the measles vaccine if they are not up-to-date with their shots after a child at Alder Hey children’s hospital in Liverpool died from the disease. The city has experienced a surge in cases among young people, with the hospital warning parents last week that the spike in infections was due to falling rates of uptake of the measles, mumps and rubella (MMR) vaccine. Continue reading...

Parents urged to get children vaccinated after measles death in Liverpool

Got damn

Watching “The Flash” & laughing 😆 my socks 🧦 off. 😂😂😂😂

LULA: “.. Brazil is a sovereign nation with independent institutions and will not accept any form of tutelage.” 🇧🇷

Evaluating another academic year, I am left asking myself whether I can do all this again. Last year costed me immensely in both mind and body health. Grant writing was particularly damming & taxing, I have found. Should I just give up? Will I miss the science?

The "reproducibility crisis" in science constantly makes headlines. Repro efforts are often limited. What if you could assess reproducibility of an entire field?

That's what @brunolemaitre.bsky.social et al. have done. Fly immunity is highly replicable & offers lessons for #metascience

A 🧵 1/n

(PDF) Confronting Scientific Racism in Psychology: Lessons from Evolutionary Biology and Genetics PDF | Some psychologists claim “new evidence” that genes, not racism, are primarily responsible for racial differences in education, income, and... | Find, read and cite all the research you need on R...

Here’s the most recent work, including discussion of the recently infamous Jordan Lasker’s work. it’s about 9,000 more words than the topic deserves

The flash flooding in Central Texas is absolutely heartbreaking. Michelle and I are praying for everyone who has lost a loved one or is waiting for news — especially the parents. And we’re grateful to the first responders and rescue teams working around the clock to help.

In which swashbuckling archaeologist Indy sits at his desk and screams in rage as an email tells him his NSF grant is terminated.

Fruit fly study reveals a gene’s hidden ability to keep regrowth on the right track | School of Molecular & Cellular Biology | Illinois Regeneration, the ability to heal damaged or lost tissues, is both everyday and a real life superpower.

How does regeneration come to a successful close when a tissue has healed?

New research from @rachelsmithbolton.bsky.social
explores this question in an article in Science Advances:

go.mcb.illinois.edu/sbJune2025

#drosophila #regeneration #ILLINOIS

Intraspecies warfare restricts strain coexistence in human skin microbiomes - Nature Microbiology About 15,000 pairwise interactions within S. epidermidis from 18 people in 6 families reveal the antagonism and molecular trade-offs that shape the skin microbiota.

🚨Out now!

About 15,000 pairwise interactions within S. epidermidis from 18 people in 6 families reveal the antagonism and molecular trade-offs that shape the skin microbiota @contaminatedsci.bsky.social @mancusosci.bsky.social #MicrobiomeSky

www.nature.com/articles/s41...

read here: rdcu.be/et7VP

A TFEB–TGFβ axis systemically regulates diapause, stem cell resilience and protects against a senescence-like state - Nature Aging Nonninger et al. identify the TFEB–TGFβ signaling axis as a regulator of stem cell resilience that protects against a senescence-like state during the adult diapause in Caenorhabditis elegans, a mecha...

1/7 🚨Out now @nataging.nature.com 🚨 We identified a genetic network of TFEB, TGFβ and NOTCH signaling regulating stem cell resilience, rejuvenation & senescence in C. elegans in response to nutrient cues, with conservation across taxa. www.nature.com/articles/s43...