Sébastien Pfeffer

"Le financement de nouveaux projets de recherche est menacé" : l'alerte de Claire Giry (ANR) L'Agence nationale de la recherche fête ses 20 ans dans un contexte de grandes tensions budgétaires. Sa présidente Claire Giry revient sur son bilan et décrypte les enjeux du moment.

[ #VeilleESR #LPPR ] Pour fêter ses 20 ans, le gouvernement envisage de baisser le budget de l'@agencerecherche.bsky.social
@claire-giry.bsky.social par @antoinebeau.bsky.social et @stephaniebenz.bsky.social

Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...

How does fever work?

Our new Science paper shows how elevated body temperature can protect against severe influenza and that avian-origin viruses escape this defence.

This is likely one reason why bird flus and some pandemic influenzas can be so severe.🧵

www.science.org/doi/10.1126/...

#RejoignezLeCNRS 🫵 Les concours chercheurs CNRS 2026 ouvrent le 8/12 !
Envie de faire avancer la science au sein d’un des plus grands organismes de recherche ?
👉 carrieres.cnrs.fr/concours-...

#ConcoursChercheurs #Science #Recherche #Icicarecrute #recrutement

BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

Are bats tolerant of all viruses? With a comparative -omics approach, we show that Egyptian fruit bat cells show both antiviral and pro-inflammatory immune responses to infection with Zika virus while our Jamaican fruit bat cells are not susceptible.
www.biorxiv.org/content/10.1...

Ce mépris venu de l’Élysée La reconduction de Sébastien Lecornu à Matignon, cinq jours après sa démission, est stupéfiante parce qu’insensée. Le président de la République a définitivement renoncé à aligner ses décisions sur les aspirations populaires. Seule compte à présent la conservation du pouvoir.

Ce mépris venu de l’Élysée

Par @ilyesramdani.bsky.social‬

BREAKING: Friday night massacre underway at CDC. Doznes of "disease detectives," high-level scientists, entire Washington staff and editors of the MMWR (Morbidity and Mortality Weekly Report) have all been RIFed and received the following notice:

Today my @nytimes.com colleagues and I are launching a new series called Lost Science. We interview US scientists who can no longer discover something new about our world, thanks to this year‘s cuts. Here is my first interview with a scientist who studied bees and fires. Gift link: nyti.ms/3IWXbiE

I researched every attempt to stop fascism in history. The success rate is 0%. Once they win elections, it's already too late.

This was an interesting read.

cmarmitage.substack.com/p/i-research...

Human MX1 orchestrates the cytoplasmic sequestration of neosynthesized influenza A virus vRNPs | PNAS Interferon-inducible Myxovirus resistance 1 (MX1) proteins are known to restrict influenza A virus (IAV) transcription/replication process. Herein,...

After years in the making, Joe McKellar @viroscope.bsky.social’s final PhD paper is finally out today in PNAS! 🎉 🎉🎉
www.pnas.org/doi/10.1073/...

RNA-guided genome protection The genome carries information across generations, ensuring species survival. To preserve faithful transmission of genetic information, RNA-directed mechanisms safeguard the genome integrity in diver…

Want to connect with researchers in #GeneRegulation, small RNAs, #StructuralBiology and more? Sign up for EMBO Workshop "RNA-guided genome protection" in Caux, Switzerland, 16–20 June 2026!

Deadline: 15 March

meetings.embo.org/event/26-gen...
#DNAsky #RNAsky #EMBORNAGenomeProtection #EMBOevents 🧪

@alphaerika.bsky.social @cmeignin.bsky.social @lucievirevolte.bsky.social @leagaucherand.bsky.social @emiliebrasset.bsky.social @deborahbourchis.bsky.social @merklinglab.bsky.social @carogoujon.bsky.social

and thank you @alphaerika.bsky.social, who was the co-supervisor of Charline's work!

Photo of Charline and her jury members after the defense

Today was a great day for Charline Pasquier, who successfully defended her PhD thesis in front of the jury composed of @annemarthe.bsky.social @ericci-aeruginosa.bsky.social, Stefania Millevoi and Jean-Luc Imler. Congratulations to her for a brilliant defense! 🍾

Today @nature.com
www.nature.com/articles/d41...

Genome-wide mapping of RNA-protein associations through sequencing - Nature Biotechnology A resource of human RNA-protein associations is produced using a sequencing-based method.

Genome-wide mapping of RNA-protein associations through sequencing go.nature.com/4gmf1Ii

Phages, viruses that infect bacteria, could help fight antibiotic resistance, but phage–host interactions are not yet sufficiently understood. Researchers from #HIRI, JMU & HZI now successfully interfered with phage reproduction using ASOs.
Just out in @nature.com:
www.nature.com/articles/s41...

An ancient and essential miRNA family controls cellular interaction pathways in C. elegans A microRNA that arose at the origin of eumetazoans regulates cell adhesion and signaling in C. elegans through conserved targets.

Our work on the function of miR-51/miR-100 is out! miR-100 is widely conserved across eumetazoans but its function has been mysterious. Emilio Santillán found in worms it regulates signaling and extracellular matrix genes, some of which seem to be conserved targets! www.science.org/doi/10.1126/...

ADAR1 as a Placental Innate Immune Rheostat Sustaining the Homeostatic Balance of Intrinsic Interferon Response at the Maternal‐Fetal Interface This study reveals that ADAR1, an RNA-editing enzyme, fine-tunes immune responses in the placenta by preventing the accumulation of immunogenic double-stranded RNAs (dsRNAs) from interferon-stimulate...

New paper from Bin Cao, showing that placenta-specific KO of ADAR1 is embryonic lethal.

#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...

A very mistaken list of the last 12 presidents of the United States and their years in office produced by the Ph.D level scholar known as ChatGPT-5. Includes John F. Katwady, president 1991-1968; George W. bush, president 220Z-1999), and Bill Christen, president 1999-2001

I've seen this on Bluesky and had to try it myself. The image below was the response to the prompt: "Show me a diagram of the US presidents since Herbert Hoover, with their names and years in office under their photos" Bravo, OpenAI, bravo.

RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...

bioRxiv bat signal going up. We have a big backlog of submissions. If any affiliates have time to do some screening, we (and all the authors) would be immensely grateful! 🙏

last call!
submit your abstract by tonight to be selected for one of the many oral presentations at the leading European Transposon Meeting. We are very much looking forward to your contribution and attendance!

Une protéine humaine héritée des bactéries révèle un pan méconnu de notre immunité - Salle de presse de l'Inserm Depuis quelques années, certains scientifiques explorent les liens inattendus entre les protéines humaines impliquées dans la défense de l’organisme et certains mécanismes immunitaires bactériens. C’e...

Une protéine humaine héritée des bactéries révèle un pan méconnu de notre immunité.

Lire le communiqué : presse.inserm.fr/une-proteine...

Dicer accumulates in cytoplasmic foci upon alphavirus infection and plays a proviral role in Myotis myotis bat cells Bats are reservoirs for many viruses that frequently cause epidemics in humans and animals. It is thus critical to better understand their immune system and mechanisms of antiviral immunity. Despite a...

🚨Preprint alert! Kind of a late notice, but here is our latest work on bat Dicer and viral infection. Work led by @leagaucherand.bsky.social and Hugo Marie in the lab. @cnrsbiologie.bsky.social @unistra.fr @frm-officiel.bsky.social

www.biorxiv.org/content/10.1...

Fatty Acid Synthase binds endogenous dsRNAs and dampens the innate immune response to exogenous dsRNAs by limiting their accumulation. In mammalian cells, the presence of double-stranded RNA (dsRNA) in the cytoplasm is a danger signal indicative of viral infection. Cells establish and maintain an antiviral state via the production of...

I am happy to share our last preprint, where we identified FASN as an endogenous dsRNA-associated factor and demonstrated that its depletion triggers endodsRNA accumulation and a stronger antiviral response to exogenous dsRNAs,#RNA, #interferon,#immunometabolism
www.biorxiv.org/cgi/content/...

The secret life of RNA and lipids There is no life without RNA or lipids. But could there be life with only RNA and lipids? The discovery that RNA can catalyse reactions in addition to encoding information opened new directions for...

Hot off the press, our latest review of RNA-lipid interactions -> The secret life of RNA and lipids: "There is no life without RNA or lipids. But could there be life with only RNA and lipids?" @tcjea.bsky.social @bcube-tud.bsky.social be-tud.bsky.social

www.tandfonline.com/doi/full/10....

Corey Allard et al asks how “solar-powered” slugs maintain stolen chloroplasts from their diet for photosynthesis and starvation resistance. @cellpress.bsky.social, @harvardmcb.bsky.social, @harvardmed.bsky.social
www.cell.com/cell/fulltex...