Chris Bellas

The Vibrio cholerae CBASS phage defence system modulates resistance and killing by antifolate antibi... High-throughput growth assays show that cyclic-oligonucleotide-based anti-phage signalling systems modulate Vibrio cholerae sensitivity to antifolates, and ultimately trigger cell lysis by these drugs...

Can a phage defence system interfere with antibiotic action? 💊 Yes, it can! CBASS is triggered by antifolates and turns these mostly bacteriostatic drugs into bactericidal ones in bugs like V. cholerae. 🦠 www.nature.com/articles/s41564-023-01556-y Read full here: rdcu.be/du20r

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