James Connolly

Finally out! Right on time for the holidays 🎄🎁
Big thanks to Nick Scott, @giseladivenanzio.bsky.social, Clay and Mario @feldmanlab.bsky.social who made it happen!

www.pnas.org/doi/10.1073/...

Join our live webinar today at 16:00 (GMT) to hear more about the VTEC conference, and why you should come. STEC/VTEC continues to be priority pathogen. The aim is to share cutting-edge scientific knowledge, addressing the questions about why the outbreaks occur and how best to manage this pathogen.

Fantastic to have Prof Matthias Wilmanns from EMBL Hamburg hosted by @kshbeckham.bsky.social to give a @mhd-newcastle.bsky.social seminar on mycobacterial infection #dreamtheme

Uncharted territory - the Akkermansia muciniphila import system at University of Birmingham on FindAPhD.com PhD Project - Uncharted territory - the Akkermansia muciniphila import system at University of Birmingham, listed on FindAPhD.com

💎MRC AIM PhD advert💎 Uncharted territory - the Akkermansia muciniphila import system.

Liang Wu, David Tourigny, and I are looking for someone to work on how A. muciniphila imports mucin.

www.findaphd.com/phds/project...

🔊 Interested in doing a PhD on RNA-binding proteins in an abundant microbiota species and becoming a member of the German Priority Programme “Illuminating Gene Functions in the Human Gut Microbiome”? Apply here: www.uni-wuerzburg.de/karriere/sin...

Today, we are lucky to have Imane El Meouche from IAME, France to give a MCM seminar @medicalsciencesncl.bsky.social (chaired by @henrikstrahl.bsky.social) on antibiotics tolerance in E. Coli

Why does daptomycin resistance appear so fast in Enterococcus? We finally have a clue.

DAP resistance in enterococci pops up quickly. What’s been missing is why resistance-associated membrane changes look the way they do, and why the classic path of mutations is so predictable.

EASTBIO: When Phages Collide: Understanding How Multiple Prophages Shape Bacterial Behaviour at University of St Andrews on FindAPhD.com PhD Project - EASTBIO: When Phages Collide: Understanding How Multiple Prophages Shape Bacterial Behaviour at University of St Andrews, listed on FindAPhD.com

Fabulous opportunity to study phage biology with Andreas Haag in St Andrews. Don’t miss out.

Theres still time to apply for our PhD project on UPEC/immune cell interactions. Deadline December 4th

A unique inhibitor conformation selectively targets the DNA polymerase PolC of Gram-positive priority pathogens - Nature Communications In this work, Urem et al. characterize the mode of action as well as mechanism of reduced susceptibility related to a class of antimicrobials that is in development for the treatment of infections wit...

🚨 Publication alert! We are stoked to report the structural basis for activity of a novel class of antimicrobials targeting Gram positive priority pathogens in @natcomms.nature.com. There is something for everyone on this paper, and I will highlight a few things below 👇 1/9 doi.org/10.1038/s414...

Looks like a great meeting :)

VTEC is One Health focused. This long standing triennial meeting has a rich history and aims to bring together researchers interested in all aspects of VTEC, including molecular pathogenesis, host response, epidemiology, diagnostics, management and prevention.

Registration is now LIVE for the 2026 international symposium on Shiga toxin producing E. coli (VTEC), being held in Aberdeen on the the 10-13th of May 2026.

The early bird deadline is February 27th so don’t miss out and register now.

www.vtec2026.org

Fantastic PhD opportunity 👇

MRC DiMeN Doctoral Training Partnership: Structural and Functional Analysis of Drug Resistance in Tuberculosis via a Novel MmpL3 Binding Site at Newcastle University on FindAPhD.com PhD Project - MRC DiMeN Doctoral Training Partnership: Structural and Functional Analysis of Drug Resistance in Tuberculosis via a Novel MmpL3 Binding Site at Newcastle University, listed on FindAPhD....

PhD opportunity with me and @kshbeckham.bsky.social

www.findaphd.com/phds/project...

Want to find ways to combat TB? Check out this PhD position 👇

MRC DiMeN Doctoral Training Partnership: Targeting thioredoxin reductase to combat antifungal resistance in Candida spp. at Newcastle University on FindAPhD.com PhD Project - MRC DiMeN Doctoral Training Partnership: Targeting thioredoxin reductase to combat antifungal resistance in Candida spp. at Newcastle University, listed on FindAPhD.com

Want to work within a multidisciplinary group to combat antifungal resistance in Candida spp? Fully-funded MRC PhD studentship in collaboration with @nclfungalgroup.bsky.social and Francesco Del Carratore on the mode of action of a new class of antifungal drugs. www.findaphd.com/phds/project...

MRC DiMeN Doctoral Training Partnership: Molecular mechanism of slow growth and antibiotic tolerance in Mycobacterium tuberculosis using single-molecule microscopy at Newcastle University on FindAPhD.... PhD Project - MRC DiMeN Doctoral Training Partnership: Molecular mechanism of slow growth and antibiotic tolerance in Mycobacterium tuberculosis using single-molecule microscopy at Newcastle Universit...

Interested in a PhD at the intersection of biophysics and microbiology?

Apply for this MRC-funded opportunity at Newcastle University to do cutting-edge microscopy in Mycobacterium tuberculosis! 🔬🦠

Closing 4 Dec!

www.findaphd.com/phds/project...

MRC DiMeN Doctoral Training Partnership: Hiding in plain sight: How multi-drug resistant pathogens evade detection and killing by human neutrophils at Newcastle University on FindAPhD.com PhD Project - MRC DiMeN Doctoral Training Partnership: Hiding in plain sight: How multi-drug resistant pathogens evade detection and killing by human neutrophils at Newcastle University, listed on Fin...

If you are interested in researching how drug resistant bacteria evade killing by our immune system, them this PhD project is for you. Come join the our team at Newcastle, in collaboration with University of Liverpool, and lead research at the interface of microbiology, immunology and metabolomics.

MRC DiMeN Doctoral Training Partnership: Hiding in plain sight: How multi-drug resistant pathogens evade detection and killing by human neutrophils at Newcastle University on FindAPhD.com PhD Project - MRC DiMeN Doctoral Training Partnership: Hiding in plain sight: How multi-drug resistant pathogens evade detection and killing by human neutrophils at Newcastle University, listed on Fin...

Exciting PhD opportunity with a great supervisor @ruamicro.bsky.social. www.findaphd.com/phds/project...

BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

Enhanced virulence and stress tolerance are signatures of epidemiologically successful Shigella sonnei
@sydneylmiles.bsky.social @katholt.bsky.social
🙏to transformative collaborative effort

www.nature.com/articles/s41...

A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics - Nature Microbiology The authors developed a screen to find compounds that modulate intracellular Staphylococcus aureus metabolism and discovered KL1, which sensitizes persisters to antibiotics by reversing host-induced tolerance.

Delighted to share our latest paper - A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics. Excellently led by Dr. Kuan-Yi Lu. We think it's a great proof-of-concept that altering immune cell behavior can make antibiotics work better www.nature.com/articles/s41...

Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.

Check it out! A proper team effort from past and present group members and a great collaboration with @sergemostowylab.bsky.social

PhD opportunity to come and work in Glasgow, developing advanced tissue culture models to study Staphylococcus aureus colonisation and infection #microsky #PhD #DTPprogram

Enquiries from potential applicants are welcome.

www.gla.ac.uk/postgraduate...

www.findaphd.com/phds/program...

Now published! www.nature.com/articles/s41...

Very nice collaboration with Hoogenboom ( @ucl.ac.uk ) and Bonev ( @uniofnottingham.bsky.social ) labs.

Introducing a new gut microbiology journal, aptly titled Gut Microbiology.

All Article Publishing Charges (APCs) are waived for 2 years!

Please send your exciting research our way.

www.sciencedirect.com/journal/gut-...

Fantastic, huge congrats Rachel!

An RNA regulates iron homeostasis and host mucus colonization in Bacteroides thetaiotaomicron Symbiotic bacteria in the human intestinal microbiota provide many pivotal functions to human health and occupy distinct biogeographic niches within the gut. Yet the molecular basis underlying niche-s...

New preprint from the lab, in collaboration with Wenhan Zhu (U Vanderbilt): using dual RNA-seq during B. theta colonization of the host mucous layer, we identify IroR--an iron-response sRNA that tunes capsule expression and facilitates adaptation to iron limitation.
doi.org/10.1101/2025.09.08.672848