Very interesting new protective response in live (!) neutrophils against bacterial infection:
27.11.2025 22:03 — 👍 0 🔁 0 💬 0 📌 0
Register now for a webinar on 8 Dec at 14:30–15:30 IST where Karin Dumstrei, Head of the EMBO Fellowships Office, will introduce the EMBO Postdoctoral #Fellowships, Scientific Exchange #Grants, eligibility and selection criteria: https://us06web.zoom.us/webinar/register/WN_cc6T61BgQQ22LMxyDFaHWg 🧪
24.11.2025 17:10 — 👍 4 🔁 4 💬 1 📌 0
Tomorrow is the final day to submit your work for presentation at #Microbio26 in Belfast!
Abstract submissions close at 23:59 GMT on Tuesday 11 November: microb.io/AC26Abstracts
10.11.2025 08:01 — 👍 4 🔁 2 💬 0 📌 1
💰We are very thankful to @kawresearch.bsky.social, @vetenskapsradet.bsky.social, SSFM, Kempe Stiftelserna, @mimsumea.bsky.social, @umeauniversitet.bsky.social, @qubelfastofficial.bsky.social, @wwiem-qub.bsky.social for support and helpful staff at @cp-cellreports.bsky.social!
14.10.2025 17:20 — 👍 1 🔁 0 💬 0 📌 0
Experiments 🔬were spearheaded by queen of illustrations 🎨 Sophie Tronnet (now building her group at @univ-amu.fr) with key computational work 🖥️ by Vikash Pandey in Oliver Billker’s lab, and great help from Miriam Lloret, Mario Pérez, Carlos Hernández, Niklas Söderholm, and Anders Nordström.
14.10.2025 17:20 — 👍 0 🔁 0 💬 1 📌 0
The response is concentration-, time-, and medium-dependent and several changes were induced by intact eATP. This implies that eATP sensing takes place at the bacterial surface. How? Some more🕵️♀️ detective work required there! 🔍 As always, stay tuned!
14.10.2025 17:20 — 👍 1 🔁 0 💬 1 📌 0
In probiotic, pathobiontic, and pathogenic Enterobacteriaceae, eATP regulates fitness and virulence factors, supporting the notion that eATP could act as intestinal site- and infection stage-dependent cue🚦in bacteria causing high eATP (Shigella, Salmonella, EPEC...) or in bystanders.
14.10.2025 17:20 — 👍 0 🔁 0 💬 1 📌 0
Good news for protective responses 🛡️against infection: eATP sensitises E. coli to antimicrobial peptides. Less good news for antibiotic therapy 💊: after eATP treatment, it can go either way.
14.10.2025 17:20 — 👍 0 🔁 0 💬 1 📌 0
And bacteria 🦠 respond to eATP, too! The response of non-pathogenic E. coli was sweeping, with 20% of the genome regulated downstream of eATP, induction of intracellular second messengers, and modulation of biofilm formation, metabolism, and cell envelope composition.
14.10.2025 17:20 — 👍 0 🔁 0 💬 1 📌 0
Redirecting
High eATP in the gut regulates inflammation and is triggered by infection.
doi.org/10.1016/j.im...
doi.org/10.1016/j.ce...
Since not only host cells but also gut microbes 🦠 are exposed to eATP,💡we wondered whether bacteria can respond to eATP fluctuations. Animals 🐕, plants 🌴, and fungi 🍄 do!
14.10.2025 17:20 — 👍 0 🔁 0 💬 1 📌 0
Tronnet et al., Cell Rep. 2025 graphical abstract: Extracellular ATP is an environmental cue in bacteria
Our first effort exploring gut bacteria-extracellular ATP interactions is published! We show that eATP rewires gene expression and physiology in harmless and pathogenic bacteria, impacting production of bioactive metabolites, antimicrobial sensitivity, and virulence. A 🧵
www.cell.com/cell-reports...
14.10.2025 17:20 — 👍 34 🔁 15 💬 2 📌 1
Enhanced virulence and stress tolerance are signatures of epidemiologically successful Shigella sonnei
@sydneylmiles.bsky.social @katholt.bsky.social
🙏to transformative collaborative effort
www.nature.com/articles/s41...
13.10.2025 21:48 — 👍 23 🔁 14 💬 1 📌 0
Many thanks also to local speakers Dessi Malinova, @selindaorrqub.bsky.social, @beckiejoingram.bsky.social, Ultan Power, @josebengoechea.bsky.social, @brendangilmore.bsky.social, co-organiser @valvanom.bsky.social, and chairs @colllab.bsky.social, @gunnarns.bsky.social, and @cisneroslab.bsky.social.
07.10.2025 15:41 — 👍 4 🔁 1 💬 0 📌 0
We had the pleasure to host Molly Ingersoll and Nassos @typaslab.bsky.social at the Fraser Symposium in Infection Biology 2025 at @qubelfastofficial.bsky.social .
The day was a delight, except for the Belfast weather (don’t trust the photo!).
Stay tuned for next year's symposium announcement!
07.10.2025 15:41 — 👍 8 🔁 1 💬 2 📌 0
Hope to see you in Belfast next June!
06.10.2025 13:04 — 👍 0 🔁 2 💬 0 📌 0
...and after a break, we've finally made it to this side!
05.10.2025 22:42 — 👍 2 🔁 0 💬 0 📌 0
Professor and Interim Chair | Dept. of Systems Biology | Columbia University | Synthetic Biology | Microbiome | Genome Engineering
http://wanglab.c2b2.columbia.edu
Lead for Molecular Microbiology @sheffielduni.bsky.social
@molmicrosheffield.bsky.social
#SEN parent, #AngelmanSyndrome
Clostridial cell biology, AMR & bacteriophage structure and function
He/Him
https://sites.google.com/sheffield.ac.uk/fagan-lab/
Lipid cell biologists who love to hang out with chemists & computer simulations experts to grasp the complex behavior of membranes
Research interests: Bacterial replication, antimicrobials, and Lyme disease. Stanford, HHMI.
Lead Scientist at the Division of Intramural Research (formerly NCBI), NLM, NIH. Bacterial signaling, c-di-GMP, c-di-AMP, protein domains, COG database
Lecturer & group leader in Lund University. Computational microbiologist, mostly working on toxin-antitoxin systems, ribosomes and bacterial defence against phages. Director of the LU-Fold protein structure prediction infrastructure of LU.
Atkinson-lab.com
How the metabolic crosstalk between pathogenic bacteria and host cells impacts infection? @pasteur.fr
Scientist at Duke studying tuberculosis, host susceptibility to infection, and mycobacterial pathogenesis. Views are my own and do not represent those of my employer.
Microbiologist, interested in alternate bacterial lifestyles - cell wall deficiency, biofilms, AMR
Molecular Biologist | Microbiologist with an interest in gene-regulation and pathogenesis. Currently in Dundee 🏴 Favourite bugs are #Pseudomonas #Coxiella #Burkholderia #UPEC
Views are my own.
Assistant Professor at the University of Louisville studying hospital associated pathogens including C. difficile and vancomycin resistant enterococci (VRE).
Interested in quantitative understanding of microbial decision making, signal transduction, motility, physiology and evolution.
https://www.mpi-marburg.mpg.de/sourjik
And all this science I don't understand, it's just my job five days a week.
Professor of Microbiome and Systems Biology @ Nottingham Trent University. 🏳️🌈
Working predominantly on the human gut microbiota.
All views my own.
3rd year PhD student in Eric Cascales Lab working on the fabulous T6SS 🏹 #T6SS
Structural biology, and beer. Not necessarily in that order.
Microbiologist, Group Leader at the John Innes Centre, UK. Our group is interested in bacterial cell biology and development. We are particularly passionate about #Streptomyces. Lab website: www.schlimpertlab.com
Professor of Microbiome Ecology at Institute of Biology, Leiden University
Bacillus subtilis, biofilms, plant microbiome, bacteria-fungi interactions and circadian clock within @microclockerc.bsky.social #ERCSyG
https://linktr.ee/atkovacs
Laboratory at @institutpasteur
working on Microbiome-Host interactions. In gut I trust. Bugs are my friends. https://www.chassainglab.com/
Biology on Infection Unit at Institut Pasteur and Inserm
Bacterial pathogenesis. Antibiotic discovery. Membrane remodelling. Structural biology #cryoEM @Imperial College, London thelowlab.org
