Tomás Gomes 🇪🇺

Tomás Gomes 🇪🇺

@tomsgoms.bsky.social

[Immune] Single-cells & sci-fi, often together | Post-doc @LGraca lab @gimmfoundation.bsky.social | Posts 🇬🇧 🇵🇹

196 Followers 321 Following 65 Posts Joined Dec 2023
2 months ago
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Inventing the randomized double-blind trial: the Nuremberg salt test of 1835 An official website of the United States government

Things I find when cleaning tabs - an early example of randomized trials, in this case for testing the efficacy of homeopathic salt dilutions

pmc.ncbi.nlm.nih.gov/articles/PMC...

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4 months ago

the best way to make progress on your paper reading list is not reading papers, it's removing the ones you've put there that you don't really need to read

(fine, it's not really progress, but definitely cuts the mental workload 😅)

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4 months ago
This is figure 2. Scat of the Asian Common Palm Civet (Paradoxurus hermaphroditus) found on a fallen log (a) and ripened berries of Robusta coffee from a coffee estate (b). Photographed by Ramit Mitra.

Coffee beans harvested from the faeces of the Asian palm civet may have higher levels of fats and other key flavour-enhancing compounds than traditionally harvested beans, according to a paper in Scientific Reports. go.nature.com/4nuNrL2 #plantscience 🧪

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4 months ago
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Is academic research becoming too competitive? Nature examines the data Applications for European research grants increased in 2025. Scientists say they’re feeling the competition.

Success rates for Europe’s leading research grants are declining as a surge in applications far outweighs the funds available

go.nature.com/479Sni6

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4 months ago
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Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com

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5 months ago
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Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...

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6 months ago

We are excited that the Earth BioGenome Project, a global network of scientists including those from the Sanger Institute, has mapped the second phase of its ambitious plan to sequence all 1.67 million known species on Earth by 2035. 👏

www.sanger.ac.uk/news_item/bi...

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6 months ago

Congrats! Looking forward from some awesome science!!

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6 months ago
A poster for the autumn school on scRNA-seq data analysis at GIMM Oeiras, Portugal. More info on the website in the post

🍂*Autumn School for Single Cell-ers 2025*🍂

Register Now! gimm.idloom.events/autumn-school
📆October 20-24
📍GIMM Oeiras, Portugal
📧scrnaseq_workshop2025@gimm.pt

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6 months ago
Ancient host-associated microbes obtained from mammoth remains A study of 483 mammoth remains spanning over a million years reveals ancient host-associated microbes preserved in bones and teeth, offering new insights into the long-term evolution of Pleistocene microbiomes and their association with megafaunal hosts.

Now online! Ancient host-associated microbes obtained from mammoth remains

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6 months ago
Baby with head in bowl of chocolate
Caption: CHOCOLATE is the ANSWER
Who cares what the question is

🔆 Good morning!

Why chocolate tastes so good:
Microbes that fine-tune its flavour 🏺🧪
www.nature.com/articles/d41...

Manipulating the microbial communities involved in cocoa bean fermentation could make chocolate even more delicious.

More delicious? Is that even possible?

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6 months ago
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What’s on at #GIMMFest Day 1 & 2? We’ll kick things off with big ideas to spark your curiosity, then dive into fresh perspectives on the future of aging and the everyday experiences that shape it.

🔗 gimm.pt/pt-pt/gimm-festival/#program

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6 months ago
An illustration of a man riding a bike surrounded by wheels and other bike parts, with text: How a Ph.D. is like riding a bike

"For half an hour, I vented everything I had been holding in for months … my supervisor … then calmly offered a line I’ll never forget: 'You are here to learn to ride a bicycle, not to invent a bicycle.' That one sentence landed softly, but it cracked something open." https://scim.ag/4lt1Ru0

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6 months ago
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Os homens estão mesmo a deixar de ler ficção? Elas estão a ler mais do que eles, principalmente romances, fantasia e thrillers. Homens escolhem a não-ficção em nome do autoaperfeiçoamento e evitam ler autoras mulheres. Mas há quem contrarie.

"Os homens estão mesmo a deixar de ler ficção?" www.publico.pt/2025/08/14/p...

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7 months ago

A positive insight of what we should take from books.

Still makes me think what would be the best way to save interesting quotes/passages from books (and same goes for papers!)

horacebianchon.substack.com/p/youre-not-...

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7 months ago

The grave risks for science as the whole of leaving fundamental scientific infrastructure in the hands of for-profit capitalist company. Essential scholarly services should be internationally curated by value-based societies/orders/colleges.
🧪

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7 months ago
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Trump order gives political appointees vast powers over research grants Researchers are alarmed that the move might upend a long-standing tradition of peer-review for grants.

The end of peer-review in the U.S.A.? www.nature.com/articles/d41... #science #research #nih #nsf #peerreview

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7 months ago
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‘Seek Funding’ Step Added To Scientific Method PARIS—In an effort to modernize the principles and empirical procedures of examining phenomena and advancing humanity’s collective knowledge, the International Council for Science announced Thursday t...

"the council was also developing a new initial step for the scientific process, “Assess Profitability of Research,” which would help determine if systematic investigation is even worth pursuing in the first place."

theonion.com/seek-funding...

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7 months ago
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Glow-in-the-dark marsupial shows off its luminous fur — July’s best science images The month’s sharpest science shots, selected by Nature’s photo team.

Glow-in-the-dark marsupials, fashionable science, and cyborg jellyfish

Check out July's best science images, chosen by Nature's photo team 📸
go.nature.com/4fgF7M8

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7 months ago
ERC funds project on algorithmic bias led by LIP researcher Joana Gonçalves-Sá, from LIP’s SPAC group, receives ERC Proof of Concept grant to audit recommendations from search engines and LLMs.

Happy to share that @spac.bsky.social was awarded an @erc.europa.eu PoC
It's a bit of an unusual one: the innovation is in policy. We want to help scientists, NGO's, journalists... implement @ec.europa.eu #DSA #Article40 and make the internet a better place
More info: www.lip.pt?lang=en&sect...

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7 months ago
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Postdoctoral Research Associate at Queen Mary University of London Discover Postdoctoral Research Associate jobs and more in higher education on jobs.ac.uk. Apply for further details on the top job board.

We are looking for a postdoctoral researcher to investigate the role of inflammation on therapy resistance in colorectal cancer using patient-derived organoids and single-cell multiomics. Please reach out if interested:
www.jobs.ac.uk/job/DNX776/p...

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7 months ago
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Sangue, saliva e urina de astronautas europeus vêm para Portugal Biobanco do Instituto Gulbenkian de Medicina Molecular foi escolhido pela Agência Espacial Europeia para acolher as amostras biológicas dos astronautas europeus. Seis mil amostras chegam já este ano.

Our Biobank has been selected by @esa.int to store the biological samples of European astronauts. The first 6 thousand samples are expected to arrive later this year.
With this agreement, GIMM becomes the sole centralized location for the preservation of these samples.
www.publico.pt/2025/07/22/c...

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8 months ago
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My postdoc work at Treutlein lab and @graycamplab.bsky.social with @jasperjanssens.bsky.social is out in @science.org ! We screen for neuron subtypes using pro-neural TFs + morphogen combinations + scRNA-seq and profiled over 700,000 cells in 480 conditions. www.science.org/doi/10.1126/...

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7 months ago
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#HotFromThePress !!

What if instead of analyzing 4-6 pathology markers you could check >100 in the *same* sample?

@maltekuehl.com & co @puellesv.bsky.social lab introduce #PathoPlex, method that could even predict disease

Full www.nature.com/articles/s41...
@focalplane.bsky.social @nature.com 🧪🔬

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7 months ago
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Horizon Europe budget to double, but €68B will remain in Competitiveness Fund The proposal for the next Horizon Europe is in, with funding increases all round, including a tripling of the budget for the EU’s innovation scheme, the European Innovation Council (EIC).The European ...

Horizon Europe budget to double, but €68B will remain in Competitiveness Fund
🧪 #AcademicSky

sciencebusiness.net/news/plannin...

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8 months ago
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Examining the orgasm gap in a diverse sample with mixed methods Research has identified gender differences in orgasm frequency during sex between heterosexual individuals. This orgasm gap is reduced for cisgender women who have sex with women, while cisgender m...

Know what has been surprising & fun about being part of Science Vs? Research we've done for the show has led to TWO peer-reviewed papers. When I returned to journalism after my MSPH, I didn't think I'd ever co-author studies.

The latest, on the "orgasm gap"👇🧪

www.tandfonline.com/doi/full/10....

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8 months ago
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Thanks Spam Email, but I'd make more progress if I didn't have to remove you constantly from my inbox. Who knows, maybe I could then even submit my work to your completely unrelated journal 😉

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8 months ago

IN RICE

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8 months ago
mRNA 3′UTRs chaperone intrinsically disordered regions to control protein activity More than 2,700 human mRNA 3′UTRs have hundreds of highly conserved (HC) nucleotides, but their biological roles are unclear. Here, we show that mRNAs with HC 3′UTRs mostly encode proteins with long intrinsically disordered regions (IDRs), including MYC, UTX, and JMJD3. These proteins are only fully active when translated from mRNA templates that include their 3′UTRs, raising the possibility of functional interactions between 3′UTRs and IDRs. Rather than affecting protein abundance or localization, we find that HC 3′UTRs control transcriptional or histone demethylase activity through co-translationally determined protein oligomerization states that are kinetically stable. 3′UTR-dependent changes in protein folding require mRNA-IDR interactions, suggesting that mRNAs act as IDR chaperones. These mRNAs are multivalent, a biophysical RNA feature that enables their translation in network-like condensates, which provide favorable folding environments for proteins with long IDRs. These data indicate that the coding sequence is insufficient for the biogenesis of biologically active conformations of IDR-containing proteins and that RNA can catalyze protein folding. ### Competing Interest Statement The authors have declared no competing interest. Pershing Square Foundation, https://ror.org/04tce9s05 G. Harold & Leila Y. Mathers Foundation National Institutes of Health, DP1GM123454, R35GM144046 Memorial Sloan Kettering Cancer Center, https://ror.org/02yrq0923, P30 CA008748

New paper:
More than 2700 human 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs.

www.biorxiv.org/content/10.1...

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8 months ago
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Portugal e a ciência integrativa: porque fazem falta centros de síntese Todos os dias são gerados milhões de dados nos mais diversos domínios científicos, mas pouco se discute sobre o que realmente fazemos com essa informação.

Portugal e a ciência integrativa: porque fazem falta centros de síntese www.publico.pt/2025/07/07/c...

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