Quick Check Needed

We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated.

mrc.tal.net/vx/appcentre...

29.10.2025 09:17 — 👍 62    🔁 54    💬 2    📌 2

We're thrilled to publish our latest research on the GLIC ion channel in PNAS!

We developed a powerful new #cryoEM data processing strategy that resolves asymmetry.

📄 Read the full paper: tinyurl.com/mustun6t 🛠️ Scripts: tinyurl.com/2n3yk29r

Stay tuned for a full tutorial soon!

#PNAS #RELION

24.10.2025 08:28 — 👍 2    🔁 1    💬 0    📌 0

Asymmetric gating of a homopentameric ion channel GLIC revealed by cryo-EM | PNAS Pentameric ligand-gated ion channels (pLGICs) are vital neurotransmitter receptors that are key therapeutic targets for neurological disorders. Alt...

Pleasure to be part of this work www.pnas.org/doi/10.1073/... with Sandip Basak at NTU where we show asymmetric gating in GLIC!

23.10.2025 16:24 — 👍 11    🔁 3    💬 0    📌 0

Special thanks to @sjorsscheres.bsky.social for developing #RELION, the powerful open-source software that made this analysis possible. If anyone has questions or would like guidance on using the scripts, please feel free to reach out!

24.10.2025 05:31 — 👍 2    🔁 0    💬 0    📌 0

Impressively, we were able to reconstruct nearly all asymmetric conformations previously proposed by @mishakudryashev.bsky.social. Below image shows the final outcome. Thanks @mishakudryashev.bsky.social for depositing the data.

24.10.2025 05:31 — 👍 2    🔁 0    💬 1    📌 0

GitHub - SandipLab/asymReconstruct: Repository for code associated with the manuscript "Asymmetric gating of a homopentameric ion channel GLIC revealed by cryo-EM" Repository for code associated with the manuscript "Asymmetric gating of a homopentameric ion channel GLIC revealed by cryo-EM" - SandipLab/asymReconstruct

This robust approach can be applied to process #cryoEM datasets of cyclic, pseudo-symmetric macromolecules. We’ve made our processing strategy available as user-friendly scripts on GitHub (tinyurl.com/3jenfw6j) and will soon upload a detailed tutorial using deposited 5-HT3AR dataset (EMPIAR-10381).

24.10.2025 05:31 — 👍 1    🔁 0    💬 1    📌 0

A big congratulations to our amazing team members
for their outstanding efforts, and thanks to our excellent collaborators @philbiggin.bsky.social and Giriraj Sahu, without whom this work would not have been possible.

24.10.2025 05:31 — 👍 3    🔁 0    💬 1    📌 0

Asymmetric gating of a homopentameric ion channel GLIC revealed by cryo-EM | PNAS Pentameric ligand-gated ion channels (pLGICs) are vital neurotransmitter receptors that are key therapeutic targets for neurological disorders. Alt...

We are excited to share our latest work on GLIC published in @pnas.org, where we developed a #cryoEM data processing strategy that allowed us to isolate and reconstruct multiple asymmetric states, revealing detailed insights into the channel’s activation mechanism. tinyurl.com/mwtb4rpj

24.10.2025 05:31 — 👍 15    🔁 5    💬 1    📌 0

Congratulations!

05.10.2025 14:27 — 👍 0    🔁 0    💬 0    📌 0

📣 Ready to lead your own lab? NTU Singapore's Nanyang Assistant Professorship offers a 100% paid salary & a S$2.75M start-up package. We're visiting the US this Sept to recruit top talent. Meet us in NYC, Boston & more! #FacultyJobs #TenureTrack

Register HERE: lnkd.in/gSy5qpA7

27.08.2025 03:24 — 👍 10    🔁 21    💬 1    📌 0

Congratulations!

09.06.2025 14:04 — 👍 1    🔁 0    💬 1    📌 0

NAP Recruitment Event Poster

Visiting Cambridge/Oxford/London w/ @sim0nredfern.bsky.social to connect w/ potential applicants for Nanyang Assistant Professorship (NAP) @ NTU SG. NAP offers tenure-track position w/ up to S$2.75M start-up. Join us and register at one of our recruitment events 👇
www.ntu.edu.sg/science/rese...

21.04.2025 10:06 — 👍 6    🔁 5    💬 0    📌 0