Good news from the ALab. We have just resubmitted our revised manuscript on the role of Homer proteins in YAP-Wnt signaling crosstalk. Here's the updated preprint: doi.org/10.1101/2025.... We’re truly grateful to the reviewers for their thoughtful comments and questions and hope they'll be happy...
My PhD student @hrshdtt.bsky.social is presenting his work at #BPS2026
Are you attending #bps2026? Don't forget to visit B305. @hrshdtt.bsky.social from our lab is presenting a poster today. On Tuesday he will be giving a talk on the same.
Sudha (@chakrapanilab.bsky.social) and Julio (@cvlab.bsky.social) are organizing the 2026 Ion Channel Gordon Research Conference: Ion Channels Across Scales — Bridging Molecular Events to Physiological Outcomes, to be held at Mount Holyoke College, July 12–17, 2026.
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Congrats!
A detailed tutorial has now been added to the GitHub page.
Excellent work. Congratulations!
We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated.
mrc.tal.net/vx/appcentre...
We're thrilled to publish our latest research on the GLIC ion channel in PNAS!
We developed a powerful new #cryoEM data processing strategy that resolves asymmetry.
📄 Read the full paper: tinyurl.com/mustun6t 🛠️ Scripts: tinyurl.com/2n3yk29r
Stay tuned for a full tutorial soon!
#PNAS #RELION
Pleasure to be part of this work www.pnas.org/doi/10.1073/... with Sandip Basak at NTU where we show asymmetric gating in GLIC!
Special thanks to @sjorsscheres.bsky.social for developing #RELION, the powerful open-source software that made this analysis possible. If anyone has questions or would like guidance on using the scripts, please feel free to reach out!
Impressively, we were able to reconstruct nearly all asymmetric conformations previously proposed by @mishakudryashev.bsky.social. Below image shows the final outcome. Thanks @mishakudryashev.bsky.social for depositing the data.
This robust approach can be applied to process #cryoEM datasets of cyclic, pseudo-symmetric macromolecules. We’ve made our processing strategy available as user-friendly scripts on GitHub (tinyurl.com/3jenfw6j) and will soon upload a detailed tutorial using deposited 5-HT3AR dataset (EMPIAR-10381).
A big congratulations to our amazing team members
for their outstanding efforts, and thanks to our excellent collaborators @philbiggin.bsky.social and Giriraj Sahu, without whom this work would not have been possible.
We are excited to share our latest work on GLIC published in @pnas.org, where we developed a #cryoEM data processing strategy that allowed us to isolate and reconstruct multiple asymmetric states, revealing detailed insights into the channel’s activation mechanism. tinyurl.com/mwtb4rpj
Congratulations!
📣 Ready to lead your own lab? NTU Singapore's Nanyang Assistant Professorship offers a 100% paid salary & a S$2.75M start-up package. We're visiting the US this Sept to recruit top talent. Meet us in NYC, Boston & more! #FacultyJobs #TenureTrack
Register HERE: lnkd.in/gSy5qpA7
Congratulations!
Visiting Cambridge/Oxford/London w/ @sim0nredfern.bsky.social to connect w/ potential applicants for Nanyang Assistant Professorship (NAP) @ NTU SG. NAP offers tenure-track position w/ up to S$2.75M start-up. Join us and register at one of our recruitment events 👇
www.ntu.edu.sg/science/rese...
