Kourtidis Lab

Kourtidis Lab

@kourtidislab.bsky.social

Where Cell-Cell adhesion meets RNAi - and other intriguing encounters. Molecular and Cellular Biology Lab at the Medical University of South Carolina in Charleston. https://medicine.musc.edu/departments/regenerative-medicine/research/kourtidis-lab

149 Followers 231 Following 25 Posts Joined Jan 2025
3 days ago
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The recent Cancer Biology and Immunology retreat of MUSC’s Hollings Cancer Center was a big success! Huge congratulations to the postdoc in the lab Carlos Gomez for winning 2nd place award for an outstanding presentation!

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2 months ago
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We had a blast celebrating the season, birthdays, and another year of science in an appropriate fashion by playing “Publish or Perish”! I also loved my present, I think the lab knows a thing or two…Happy Holidays from our lab!

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3 months ago
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The graduate students in the lab Houda Mesnaoui and Jordan Jarvis gathering crowds at the @ascbiology.bsky.social #CellBio2025!

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4 months ago
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Congratulations to the PhD Students in the lab Houda Mesnaoui and Jordan Jarvis for obtaining not one, but TWO MUSC awards each: a T32 Research Enhancement Initiative Award and an Emerging Scholars Travel Award to participate in the upcoming @ascbiology.bsky.social Cell Bio meeting. Well done both!

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4 months ago
Representative images of Caco2+LZRS, PIWIL2 KO+LZRS and PIWIL2 KO+PIWIL2-FLAG cells grown in anchorage independent conditions after 7 days.

@sciencealyssa.bsky.social, @kourtidislab.bsky.social & co investigate the PIWI-piRNA pathway in #coloncancer using a nuanced bioinformatic and cell-based approach, linking the downregulation of PIWIL2 to disease progression, transposable element activation and DNA damage. doi.org/10.1242/bio....

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4 months ago
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Big day for the lab today! Our DMD/PhD student Christina Kingsley and the PhD student Jordan Jarvis won 1st place poster and 1st place oral presentation Awards, respectively, during the MUSC College of Graduate Studies #ResearchDay! Congratulations to both!

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4 months ago
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I had a blast riding alongside more than 1500 bike riders for #lowvelo and #Hollings Cancer Center @muschealth.bsky.social to help raise money for life-saving #cancer #research! The fundraising continues, help me reach our goal! To learn more and donate: fundraise.musc.edu/fundraiser/6...

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4 months ago
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Happy Halloween from our lab!

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4 months ago
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The big day is here! We ride again on November 1st across #Charlestonsc to support the vital mission of Hollings Cancer Center at MUSC to discover new cures and fight #cancer. 100% of donated funds go directly to life-saving cancer #research. Learn more and donate: fundraise.musc.edu/fundraiser/6...

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6 months ago
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PIWIL2 downregulation in colon cancer promotes transposon activity and pro-tumorigenic phenotypes Summary: This study investigates the PIWI-piRNA pathway in colon cancer using a nuanced bioinformatic and cell-based approach, linking the downregulation of PIWIL2 to disease progression, transposable...

Excited to share our most recent publication, where we delve into the roles of the #PIWI - #piRNA pathway in #transposon regulation, in #epithelial #homeostasis and #cancer. Fabulous work by the recently graduated student in the lab @sciencealyssa.bsky.social journals.biologists.com/bio/article/...

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6 months ago

It has been a little while since I have posted here on BlueSky but a huge thank you to the Kourtidis Lab team for making my defense so special! It is an honor!

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6 months ago
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Huge congratulations to Alyssa Risner @sciencealyssa.bsky.social for doing a phenomenal job and successfully defending her Thesis! Very proud of her for her hard work and outstanding contributions, but also for her being a true team player. Well done Dr. Risner, best of luck in the new life ahead!

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6 months ago

Very insightful by Martin Schwartz, as always: Why would anyone want to be a scientist?

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8 months ago
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The subcellular topology of the RNAi machinery is multifaceted and reveals adherens junctions as an epithelial hub - Scientific Reports Scientific Reports - The subcellular topology of the RNAi machinery is multifaceted and reveals adherens junctions as an epithelial hub

Very happy to share our latest work revealing that localization of the #RNAi machinery at #adherens junctions is a universal feature of #epithelial cells and tissues. Great work and team effort by Joyce Nair-Menon, the lab and collaborators! @sciencealyssa.bsky.social www.nature.com/articles/s41...

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10 months ago
The phosphorylated form of α-catenin localizes to the apical portion of adherens junctions. The image shows 3D surface rendering using Imaris software of a confocal image of a dividing kidney epithelial cell line (Madin–Darby canine kidney or MDCK cells). Phosphorylated α-catenin is shown in magenta and adherens junctions are in green.

🧪Phuong Le, Jeanne Quinn, @jfhorner.bsky.social @carajgottardi.bsky.social & co show that the adhesion protein α-catenin has a key modification that allows dividing cells to stay better connected to their neighbours, helping the tissue stick together during mechanical stress. doi.org/10.1242/bio....

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11 months ago

Well done Rachel, Amy and amazing Team!

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11 months ago

😄

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11 months ago

Hope you get it through…we have delays on getting non-competing 2nd yr etc NOAs too, hopefully it’s only delays due to the current mess…

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11 months ago

Oh no! Get well soon Diana!

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11 months ago

Yes, we got one approved late February - after many days though that not even the NCE “button” on eRA commons was available…are you having issues with yours?

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11 months ago
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The NTDscope is a portable brightfield, darkfield, and fluorescence microscope used for the diagnosis of neglected tropical diseases (NTDs). Check out our latest preprint: www.medrxiv.org/content/10.1...

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11 months ago

Fascinating!

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11 months ago
graph of NIH basisfor new drugs

A pie graph worth keeping in mind as the NIH budget plummets jamanetwork.com/journals/jam... for 356 new FDA drugs approved

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11 months ago
"When a complex system is far from equilibrium, small islands of coherence in a sea of chaos have the capacity to shift the entire system to a higher order."
Iya Prigogine, Noble prize-winning chemist

"When a complex system is far from equilibrium, small islands of coherence in a sea of chaos have the capacity to shift the entire system to a higher order."

Iya Prigogine, Noble prize-winning chemist

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11 months ago

me, as a senior PI: US science as we know it may be ending? Review these cool manuscripts? Serve on these grant review panels? Yes! All in! Going down in a blaze of glory!

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11 months ago

😂

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1 year ago

Fantastic work Ankita and especially amidst all that’s happening - huge congratulations!

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1 year ago
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CD44 and Ezrin restrict EGF receptor mobility to generate a novel spatial arrangement of cytoskeletal signaling modules driving bleb-based migration Cells under high confinement form highly polarized hydrostatic pressure-driven, stable leader blebs that enable efficient migration in low adhesion, environments. Here we investigated the basis of the...

As scientist I am going through difficult times (this is understatement of the year for me!!). Past one and half months have been horrible, however I am trying to pick myself up and super excited to share my postdoc work with the community! #cellmigration
www.biorxiv.org/content/10.1...

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1 year ago
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Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter
www.nytimes.com/2025/03/01/u...

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1 year ago

I wrote a book The Creative Destruction of Medicine (2013, title adopted after Schumpeter).

This title of the book for what we are now seeing in the U.S. is just The Destruction of Medicine.

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