CIRTN-R2FIC

Circulating senescence-associated secretory phenotype factors across the stages of type 1 diabetes in a cross-sectional cohort - Scientific Reports Scientific Reports - Circulating senescence-associated secretory phenotype factors across the stages of type 1 diabetes in a cross-sectional cohort

(🧵10/10) For the second half of Nov. 2025:
From Dr. Peter Thompson:
"Circulating senescence-associated secretory phenotype factors across the stages of type 1 diabetes in a cross-sectional cohort" PMID: 41258222
www.nature.com/articles/s41...

(🧵9/10) For the second half of Nov. 2025:
From Dr. Stefan Taubert:
"Impact of bacterial inactivation methods on Caenorhabditis elegans feeding and healthspan" PMID: 41276563
www.nature.com/articles/s41...

(🧵8/10) For the second half of Nov. 2025:
From Dr. James Shapiro:
"Extracellular Matrix-Guided Islet Cell Transplantation Results in Improved Glycemic Control in a NOD-SCID Mouse Model" PMID: 41297833
www.thieme-connect.com/products/ejo...

Frontiers | Editorial: In vivo magnetic resonance imaging of metabolic disorders Metabolic health depends on the balance between energy expenditure through oxidation, substrate supply, and substrate storage. When this balance is disrupted...

(🧵7/10) For the second half of Nov. 2025:
From Dr. Guy Rutter:
"Editorial: In vivo magnetic resonance imaging of metabolic disorders" PMID: 41323968
www.frontiersin.org/journals/end...

Protocol to measure insulin secretion dynamics from single mouse islets using a microfluidic fluorescence anisotropy immunoassay The dynamics of glucose-stimulated insulin secretion (GSIS) from islets offer valuable insight into β cell metabolism. Here, we present a protocol for…

(🧵6/10) For the second half of Nov. 2025:
From Dr. Jonathan V Rocheleau:
"Protocol to measure insulin secretion dynamics from single mouse islets using a microfluidic fluorescence anisotropy immunoassay" PMID: 41259206
www.sciencedirect.com/science/arti...

Biological sex affects human islet gene expression and mitochondrial function in type 2 diabetes The clinical characteristics of type 2 diabetes (T2D) differ between the sexes. For example, the risk of T2D is higher in males than in premenopausal females, whereas the risk of T2D-associated cardio...

(🧵5/10) For the second half of Nov. 2025:
From Drs. Elizabeth Rideout and Jim Johnson :
"Biological sex affects human islet gene expression and mitochondrial function in type 2 diabetes" PMID 41292752
www.biorxiv.org/content/10.1...

(🧵4/10) 2nd half of Nov. 2025:
From Dr. R. Rabasa-Lhoret:
"Despite lower [hA1c] with second-generation automated insulin delivery systems, mental burden remains high for all adults with [T1D]: A BETTER registry analysis" PMID: 41250885
dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...

Supervised machine learning identifies impaired mitochondrial quality control in β cells with development of type 2 diabetes In type 2 diabetes (T2D), molecular pathways driving β cell failure are difficult to resolve with standard single cell analysis. Here we developed an interpretable, supervised machine learning framewo...

(🧵3/10) For the second half of Nov. 2025:
From Dr. Patrick MacDonald:
"Supervised machine learning identifies impaired mitochondrial quality control in β cells with development of type 2 diabetes" PMID: 41278904
www.biorxiv.org/content/10.1...

Hepatic p38α at the forefront of high fat diet-induced insulin resistance, hepatic steatosis, and liver-periphery cross-talk | American Journal of Physiology-Endocrinology and Metabolism | American Ph... Mitogen-activated protein kinases play an essential role in the onset of hepatic metabolic dysregulation; however, current data fail to establish a definitive role for p38. We generated a hepatocyte-s...

(🧵2/10) For the second half of Nov. 2025:
From Dr. Adria Giacca
"Hepatic p38α at the forefront of high fat diet-induced insulin resistance, hepatic steatosis, and liver-periphery cross-talk” PMID: 41213160
journals.physiology.org/doi/abs/10.1...

(🧵1/10) Diabetes Awareness Month has come to a close, and CIRTN Labs had many publications!🤩
For the second half of Nov. 2025 we have papers from Drs. Giacca, MacDonald, Rabasa-Lhoret, Rideout, Johnson, Rocheleau, Rutter, Shapiro, Taubert and Thompson.

A bit about "Islets in a Pod": our series is meant to better introduce the CIRTN-R2FIC network, the PIs and the trainees. We also aim to continue promoting camaraderie amongst the members.
More interviews to come from both PIs and trainees that were at the Annual Meeting!

YouTube video by CIRTN-R2FIC #1 Islets in a Pod with Dr. Patrick MacDonald

CIRTN-R2FIC is currently running in Toronto its 4th Annual Meeting. During this meeting we have launched our mini interview series called "Islets in a Pod" ! Our first interview is with Dr. Patrick MacDonald from the University of Alberta.
youtu.be/UlHn_1Fz3ck?...

Early Postpartum Glucose Tolerance Reclassification by Gestational Diabetes Subtype This cohort study evaluates whether different subtypes of gestational diabetes are associated with different prevalence rates for postpartum prediabetes.

🧵(12/12) For the beginning of Nov 2025:
From Dr. Michael B. Wheeler
"Early Postpartum Glucose Tolerance Reclassification by Gestational Diabetes Subtype" PMID: 41212558
jamanetwork.com/journals/jam...

Additive Effects of Dorzagliatin and Glucagon-Like Peptide-1 Receptor Agonism in a Novel Mouse Model of GCK-MODY and in Obese db/db Mice Glucokinase (GK) catalyzes the key regulatory step in glucose-stimulated insulin secretion (GSIS). Correspondingly, hetero- and homozygous mutations in hum

🧵(11/12) For the beginning of Nov 2025:
From Dr. Guy Rutter
"Additive Effects of Dorzagliatin and Glucagon-Like Peptide-1 Receptor Agonism in a Novel Mouse Model of GCK-MODY and in Obese db/db Mice" PMID: 41196662
diabetesjournals.org/diabetes/art...

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

🧵(10/12) For the beginning of Nov 2025:
From Dr. Michael Riddell
"Continuous Glucose Monitoring Profiles in Elite-Level Professional European Football Players" PMID: 41237017
journals.sagepub.com/doi/10.1177/...

Transcriptional and temporal heterogeneity of developing α cells revealed by single-cell RNA sequencing Glucagon (Gcg)-expressing pancreatic α cells play pivotal roles in maintaining glucose and amino acid homeostasis; however, the cellular heterogeneity…

🧵(9/12) For the beginning of Nov 2025:
From Dr. Francis Lynn
"Transcriptional and temporal heterogeneity of developing α cells revealed by single-cell RNA sequencing" PMID 41242298
www.sciencedirect.com/science/arti...

An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function Siglec-liposomes are a multivalent and modular platform for profiling Siglec ligands and modulating immune cell function.

🧵(8/12) For the beginning of Nov 2025:
From Dr. Megan K. Levings
"An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function" PMID 41223255
www.science.org/doi/10.1126/...

Label-free estimation of regulatory T cell activation markers using Raman spectroscopy with machine learning - Scientific Reports Scientific Reports - Label-free estimation of regulatory T cell activation markers using Raman spectroscopy with machine learning

🧵(7/12) For the beginning of Nov 2025:
From Dr. Megan K. Levings
"Label-free estimation of regulatory T cell activation markers using Raman spectroscopy with machine learning" PMID: 41188301
www.nature.com/articles/s41...

🧵(6/12) For the beginning of Nov 2025:
From Dr. Tatsuya Kin
"Benchmarking porcine pancreatic ductal organoids for drug screening applications" PMID: 41188536
www.embopress.org/doi/full/10....

An Accessible Platform to Quantify Oxygen Diffusion in Cell‐Laden Hydrogels and Its Application to Alginate‐Immobilized Pancreatic Beta Cells A simple setup to measure oxygen diffusion coefficients was developed using equipment accessible to most wet laboratories. Gels that appeared softer and had lower loss moduli correlated with higher o...

🧵(5/12) For the beginning of Nov 2025:
From Dr. Corinne Hoesli
"An Accessible Platform to Quantify Oxygen Diffusion in Cell-Laden Hydrogels and Its Application to Alginate-Immobilized Pancreatic Beta Cells" PMID: 41220227
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...

🧵(4/12) For the beginning of Nov 2025:
From Dr. David Hill
"Pancreatic Cancer and Diabetes: Insights, Hypotheses, and Next Steps" PMID: 41226286
www.mdpi.com/1422-0067/26...

Glucagon, the Alpha Cell, and Potential Targets for Diabetes Treatment Abstract. Glucagon is a 29-amino acid hormone synthesized and secreted by the pancreatic alpha cell in the islets of Langerhans. It is the primary glucose

🧵(3/12) For the beginning of Nov 2025:
From Dr. Savita Dhanvantari
"Glucagon, the Alpha Cell, and Potential Targets for Diabetes Treatment" PMID: 41206016
academic.oup.com/endo/advance...

Insulin production is sustained during DNA damage-mediated senescence in adult human beta cells - Diabetologia Aims/hypothesis Residual pancreatic beta cells in type 1 diabetes show reduced insulin production but the mechanisms remain unclear. Beta cells undergo stress responses during type 1 diabetes, includi...

🧵(2/12) For the beginning of Nov 2025:
From Drs Peter Thompson, Bruce Verchere and Yi-Chun Chen
"Insulin production is sustained during DNA damage-mediated senescence in adult human beta cells" • PMID: 41231256
link.springer.com/article/10.1...

🧵(1/12) November is Diabetes Awareness Month, and we have many works coming out from the CIRTN labs focusing on islet biology and diabetes. For the beginning of Nov 2025, we have papers from Drs Thompson, Verchere, Chen, Dhanvantari, Hill, Hoesli, Kin, Levings, Lynn, Riddell, Rutter and Wheeler.

ABHD6 suppression attenuates pro-inflammatory responses in mice and promotes anti-inflammatory polarization of macrophages during endotoxin stress α/β-hydrolase domain-containing-6 (ABHD6) hydrolyzes various lipids, including monoacylglycerols (MAGs). Pharmacological inhibition of ABHD6 with WWL7…

🧵(4/4) end of Oct 2025.
3) From Dr. Marc Prentki
"ABHD6 suppression attenuates pro-inflammatory responses in mice and promotes anti-inflammatory polarization of macrophages during endotoxin stress" PMID: 41061850
www.sciencedirect.com/science/arti...

Lactic acid improves Treg manufacturing and in vivo function Addition of lactic acid to a human Treg manufacturing protocol enhanced viability, expansion, purity, and suppressive function. Lactic acid also reduced tonic CAR signaling, preventing expression of e...

🧵(3/4) end of Oct 2025.
2) From Dr. Megan Levings
"Lactic acid improves Treg manufacturing and in vivo function" PMID: 41146876
www.cell.com/molecular-th...

The antioxidant, N-acetyl-L-cysteine, affects beta cell oxidative stress, insulin secretion, and intracellular signaling pathways in MIN6 cells - Cell and Tissue Research There is intense public interest in the potential of antioxidant supplements as a preventative treatment for conditions associated with increased oxidative stress, such as type 2 diabetes mellitus. Ho...

🧵(2/4) end of Oct 2025.
1) From Dr. Rennian Wang.
"The antioxidant, N-acetyl-L-cysteine, affects beta cell oxidative stress, insulin secretion, and intracellular signaling pathways in MIN6 cells" PMID: 41165773
link.springer.com/article/10.1...

🧵(1/4) We have finished up October 2025 🎃, and the CIRTN groups had several more publications coming from the labs of Drs Rennian Wang, Megan Levings and Marc Prentki.

I-BET151 modulates glucokinase gene expression and beta cell function in part through changes in FOXO1 expression - Diabetologia Aims/hypothesis The bromodomain and extra-terminal (BET) protein family acts as ‘epigenetic readers’ to identify the acetylation marks on histones that convert the acetylated lysine residues into obse...

🧵(4/4) For the first half of October 2025
Lab of Dr. Guy Rutter
"I-BET151 modulates glucokinase gene expression and beta cell function in part through changes in FOXO1 expression"
PMID: 41003698
link.springer.com/article/10.1...

🧵(3/4) For the first half of October 2025
Labs of Drs. Francis Lynn, James Shapiro and Tatsuya Kin
"Truncated CD19 as a selection marker for the isolation of stem cell derived β-cells"
PMID: 41048051
journals.biologists.com/dmm/article/...