Attending #biome2025 day 1. Main takeaways from the keynote by Travis York were: 1.The main thing is to keep the main thing, the main thing; and 2. Burnout is real but so is pragmatic hope. Thank you for sharing the many @aaas.org project.

22.07.2025 00:29 — 👍 1    🔁 1    💬 0    📌 0

KEGG PATHWAY: Pathways in cancer - Homo sapiens (human)

Yesterday I began exploring the 3D shapes & interactions of biological macromolecules that play a role in #cancer. I am looking at proteins listed in www.kegg.jp/pathway/hsa0... & plan to share what I learn through weekday posts. Join me in my journey of learning about cancer in molecular detail

11.07.2025 14:43 — 👍 0    🔁 0    💬 0    📌 0

pdb_00003wu1

Today I learned about the Acute myeloid leukemia 1 (AML1) protein or the Runt-related transcription factor 1. It's runt domain recognizes the core consensus DNA sequence 5'-TGTGGT-3' or 5'-TGCGGT-3' and is essential for the development of normal hematopoiesis (PDB ID 3wu1).

11.07.2025 01:27 — 👍 0    🔁 0    💬 0    📌 0

Mining the CRBN target space redefines rules for molecular glue–induced neosubstrate recognition The CRL4CRBN E3 ubiquitin ligase is the target of molecular glue degrader compounds that reprogram ligase specificity to induce the degradation of clinically relevant neosubstrate proteins. Known cere...

Molecular glue degraders (MGDs) reprogram E3 ubiquitin ligases to target & destroy proteins. Thalidomide analogs bind cereblon (CRBN) as clinically effective MGDs.
Mining the CRBN target space redefines rules for molecular glue–induced neosubstrate recognition www.science.org/doi/10.1126/...

04.07.2025 15:32 — 👍 1    🔁 0    💬 0    📌 0

pdb_00006qtk

In March, @usfda.bsky.social approved Gepotidacin, a first-in-class novel bacterial topoisomerase inhibitor (NBTI), for treating uncomplicated urinary tract infections. The structure of gepotidacin bound to S.aureus DNA gyrase & doubly nicked DNA sheds light on mechanism of #antibiotic action

03.07.2025 21:49 — 👍 0    🔁 0    💬 0    📌 0

pdb_00006nr2

In May the @usfda.bsky.social has approved aclotremon to treat symptoms of dry eye disease & helps your #eyes produce more natural tears. The drug binds to transient receptor potential melastatin member 8 (TRPM8), a Ca2+ –permeable cation channel, & the primary cold/menthol sensor in humans.

02.07.2025 20:57 — 👍 0    🔁 0    💬 0    📌 0

structure of coagulation factor beta-XIIa in complex with the garadacimab Fab fragment (pdb_00008r8d)

Beginning a journey on bsky exploring a molecular view of biology and medicine. Today's subject is the inhibition of beta FXIIa by garadacimab. Last month this monoclonal antibody was approved by @usfda.bsky.social for treating hereditary angioedema.

01.07.2025 22:00 — 👍 1    🔁 0    💬 0    📌 0