UCSF Center for Tuberculosis

🚨 Satellite session at #UnionConf2025!
“Transforming TB detection with tongue swab-based molecular testing”
🗓️ Nov 19 | 8–9AM | Copenhagen

Beyond sputum: tongue swabs + near-POC molecular tools.

unionconf2025.abstractserver.com/programme/#/...

#TB #GlobalHealth #Diagnostics

Accelerating cough-based algorithms for pulmonary tuberculosis screening: Results from the CODA TB DREAM Challenge AbstractBackground. Open-access data challenges can accelerate innovation in artificial-intelligence (AI)-based tools. In the Cough Diagnostic Algorithm fo

Can a smartphone-recorded cough help detect #TB? The CODA TB DREAM Challenge shows promise: AI + clinical data reached 73.8% specificity at 80% sensitivity across 7 countries. Read more: academic.oup.com/ofid/advance...

Preferences for tuberculosis diagnostic test features among people tested for tuberculosis: a multicountry discrete choice experiment Individuals accessing tuberculosis services across high-burden settings universally value low to no cost tests, high diagnostic accuracy, and rapid result availability. These findings underscore the n...

New Lancet study in Philippines, Vietnam, South Africa, Uganda & India:

People tested for #TB prioritize diagnostics that are
• Low-cost
• Accurate
• Deliver results in 15 minutes

Findings show need to align WHO TPPs with patient preferences.
www.thelancet.com/journals/lan...

Welcome! You are invited to join a meeting: Innovating Against TB - Community Driven Solutions to TB Challenges. After registering, you will receive a confirmation email about joining the meeting. Please join the Coalition for a TB Free California (CTFC) and the Association of Asian and Pacific Health Organizations (AAPCHO) for an engaging webinar highlighting three innovative TB programs that ...

Join us for Innovating Against #TB – Community Solutions to TB Challenges

📅 Thurs, Sept 11, 2025
🕐 1–2 PM PT | 4 PM ET
✅ Up to 1 CE hour

Hear from leaders & advocates on TB programs driving change via education, advocacy & services.

🔗 Register: us02web.zoom.us/meeting/regi...

#Tuberculosis

Bedaquiline, delamanid, linezolid, and clofazimine for rifampicin-resistant and fluoroquinolone-resistant tuberculosis (endTB-Q): an open-label, multicentre, stratified, non-inferiority, randomised, c... Pre-extensively drug-resistant (pre-XDR) tuberculosis (ie, multidrug-resistant or rifampicin-resistant with additional resistance to any fluoroquinolo…

Results from the endTB-Q trial (MSF, PIH, IRD, UCSF CTB): BDLC (bedaquiline, delamanid, linezolid, clofazimine) was not non-inferior to standard regimens for pre-XDR #TB. Longer/stronger treatments may be needed.
www.sciencedirect.com/science/arti...

Plasma proteomics for biomarker discovery in childhood tuberculosis - Nature Communications In this work, through a comprehensive proteomics approach, the authors identified host plasma protein biosignatures that could distinguish tuberculosis (TB) disease in children.

We need new biomarkers to improve TB diagnosis in children. In the COMBO study, we performed a comprehensive plasma proteomic analysis across 4 countries and found several protein signatures that met the WHO target accuracy for a TB screening test: www.nature.com/articles/s41...

#tbsky #idsky

Scale-up of 99DOTS for tuberculosis treatment supervision in Uganda: An interrupted time series analysis Background Digital adherence technologies like 99DOTS are being scaled-up for tuberculosis (TB) treatment despite limited evidence of their effectiveness and concerns about accessibility. We evaluated...

Can digital adherence tools improve #TB care at scale? We evaluated 99DOTS in Uganda during national scale-up. High uptake (87%), no harm to outcomes, but equity in access remains key. Read more: www.medrxiv.org/content/10.1... #tuberculosis

In our study of 2,904 adults with #TB symptoms across five high TB-burden countries, CRP-based screening had 84% sensitivity and 61% specificity. Though CRP didn’t meet minimum diagnostic targets overall, its accuracy varied by setting and subgroup. www.atsjournals.org/doi/10.1164/...

WHO announces landmark changes in treatment of drug-resistant #tuberculosis createsend.com/t/d-0CC16B59...

Dr. Ann M Loeffler will be presenting on advances and local strategies in pediatric #TB at the UCSF Department of Pediatrics Grand Rounds this Thursday, April 17th, from 12-1pm. Attend in person at Oberndorf Auditorium or via Zoom: bit.ly/3Go7Np2

The Accuracy of the Uganda National Tuberculosis and Leprosy Program diagnostic algorithm and the World Health Organisation treatment decision algorithms for childhood tuberculosis: A retrospective an... Author summary In this study, we assessed and compared the accuracy of the 2017 Uganda National TB and Leprosy Program (NTLP) algorithm with the 2022 World Health Organization (WHO) Treatment Decision...

Our study compared Uganda’s #TB treatment decision algorithm for children with the WHO's. We found these TDAs can help diagnose more TB cases, but could also lead to overtreatment. Better tests are needed to confirm TB in children. dx.plos.org/10.1371/jour...
#Tuberculosis #ChildHealth #Uganda #WHO

Despite being preventable, #TB affects thousands in the US. A major barrier to TB elimination is the lack of Medicare coverage for TB infection screening and testing. Our team describes how this policy gap affects US TB elimination efforts. rdcu.be/efcBa #TBPrevention #Medicare #CTB

The Fight Against TB Was Frozen in Time, Until Now. See Its Future Tuberculosis has stalked humanity for as nearly as long as we've been on earth. In this article, we take a look at how UCSF is leading the fight against the leading infectious disease killer.

Learn about how faculty at the UCSF Center for Tuberculosis are waging the fight against #TB www.ucsf.edu/news/2025/03...